Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 430-440

  Xiao, Jia ^a,b   Liong, Emily C ^b   Huang, Hai ^b   Tse, Wing On ^b   Lau, Kam Shing ^b   Pan, Jingfei ^b   Nanji, Amin A ^c   Fung, Man Lung ^b   Xing, Feiyue ^a   Tipoe, George L ^b  

^a JINAN UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

5 lipoxygenase; Acute liver injury; Carbon tetrachloride; Cyclooxygenase; Prostaglandin

Indexed keywords

AMINOTRANSFERASE; CARBON TETRACHLORIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLOOXYGENASE 1; CYTOCHROME P450 2E1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOXYGENASE; PROSTAGLANDIN E2; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATION; KNOCKOUT MOUSE; LIVER INJURY; LIVER PROTECTION; LIVER REGENERATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENZYMOLOGY; GENETICS; HETEROZYGOTE; HOMOZYGOTE; IMMUNOLOGY; LIVER FUNCTION TEST; OXIDATIVE STRESS; PATHOLOGY; TUNEL ASSAY;

MUS;

ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; CYCLOOXYGENASE 1; CYTOKINES; DINOPROSTONE; DRUG-INDUCED LIVER INJURY; HETEROZYGOTE; HOMOZYGOTE; IN SITU NICK-END LABELING; LIVER FUNCTION TESTS; MICE, KNOCKOUT; OXIDATIVE STRESS;

EID: 84924703568     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu244     Document Type: Article

References (34)

1. Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009). The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55, 611-622.
2. Carey, M. A., Bradbury, J. A., Seubert, J. M., Langenbach, R., Zeldin, D. C., and Germolec, D. R. (2005). Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J. Immunol. 175, 6878-6884.
3. Cha, Y. I., and DuBois, R. N. (2007). NSAIDs and cancer prevention: targets downstream of COX-2. Ann. Rev. Med. 58, 239-252.
4. Chandrasekharan, N. V., Dai, H., Roos, K. L., Evanson, N. K., Tomsik, J., Elton, T. S., and Simmons, D. L. (2002). COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl Acad. Sci. U. S. A. 99, 13926-13931.
5. Chen, J. H., Tipoe, G. L., Liong, E. C., So, H. S., Leung, K. M., Tom, W. M., Fung, P. C., and Nanji, A. A. (2004). Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by downregulating inducible nitric oxide-derived prooxidants. Am. J. Clin. Nutr. 80, 742-751.
6. Choi, S. H., Langenbach, R., and Bosetti, F. (2008). Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J. 22, 1491-1501.
7. Daikoku, T., Tranguch, S., Trofimova, I. N., Dinulescu, D. M., Jacks, T., Nikitin, A. Y., Connolly, D. C., and Dey, S. K. (2006). Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res. 66, 2527-2531.
8. Gill, R. Q., and Sterling, R. K. (2001). Acute liver failure. J. Clin. Gastroenterol. 33, 191-198.
9. Gyllfors, P., Bochenek, G., Overholt, J., Drupka, D., Kumlin, M., Sheller, J., Nizankowska, E., Isakson, P. C., Mejza, F., Lefkowith, J. B., et al. (2000). Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. Gastroenterology 119, 794-805.
10. Hamada, T., Sato, A., Hirano, T., Yamamoto, T., Son, G., Onodera, M., Torii, I., Nishigami, T., Tanaka, M., Miyajima, A., et al. (2007). Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats. Am. J. Pathol. 171, 872-881.
11. Harris, S. G., Padilla, J., Koumas, L., Ray, D., and Phipps, R. P. (2002). Prostaglandins as modulators of immunity. Trends Immunol. 23, 144-150.
12. Holgate, S. T., Peters-Golden, M., Panettieri, R. A., and Henderson,W. R., Jr. (2003). Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J. Allergy Clin. Immunol. 111, S18-S34; discussion S34-S36.
13. Khan, R. A., Khan, M. R., and Sahreen, S. (2012). CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement. Altern. Med. 12, 178.
14. Lampiasi, N., Fodera, D., D'Alessandro, N., Cusimano, A., Azzolina, A., Tripodo, C., Florena, A. M., Minervini, M. I., Notarbartolo, M., Montalto, G., et al. (2006). The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int. J. Mol. Med. 17, 245-252.
15. Li, L., Liu, Y. R., Gao, S., Li, J. F., Li, S. S., Zhang, D. D., Liu, S., Bai, L., Zheng, S. J., Duan, Z. P., et al. (2014). Inhibition of 5-lipoxygenase pathway attenuates acute liver failure by inhibiting macrophage activation. J. Immunol. Res. 2014, 697560.
16. Liong, E. C., Xiao, J., Lau, T. Y., Nanji, A. A., and Tipoe, G. L. (2012). Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model. Food Chem. Toxicol. 50, 861-866.
17. Liu, C., Tao, Q., Sun, M., Wu, J. Z., Yang, W., Jian, P., Peng, J., Hu, Y., Liu, C., and Liu, P. (2010). Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab. Invest. 90, 1805-1816.
18. Martin-Sanz, P., Mayoral, R., Casado, M., and Bosca, L. (2010). COX-2 in liver, from regeneration to hepatocarcinogenesis: what we have learned from animal models? World J. Gastroenterol. 16, 1430-1435.
19. McGeehan, M., and Bush, R. K. (2002). The mechanisms of aspirin-intolerant asthma and its management. Curr. Allergy Asthma Rep. 2, 117-125.
20. Nakamura, K., Nonaka, H., Saito, H., Tanaka, M., and Miyajima, A. (2004). Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology 39, 635-644.
21. Pritchard, M. T., Cohen, J. I., Roychowdhury, S., Pratt, B. T., and Nagy, L. E. (2010). Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice. J. Hepatol. 53, 655-662.
22. Rudnick, D. A., Perlmutter, D. H., and Muglia, L. J. (2001). Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Proc. Natl Acad. Sci. U. S. A. 98, 8885-8890.
23. Rutherford, A., and Chung, R. T. (2008). Acute liver failure: mechanisms of hepatocyte injury and regeneration. Semin. Liver Dis. 28, 167-174.
24. Schemmer, P., Schoonhoven, R., Swenberg, J. A., Bunzendahl, H., and Thurman, R. G. (1998). Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells. Transplantation 65, 1015-1020.
25. Spencer, S. L., and Sorger, P. K. (2011). Measuring and modeling apoptosis in single cells. Cell 144, 926-939.
26. -/- knockout mice. J. Cardiovasc. Pharmacol. 46, 761-765.
27. Tang, E. H., Libby, P., Vanhoutte, P. M., and Xu, A. (2012). Antiinflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J. Cardiovasc. Pharmacol. 59, 116-123.
28. Tanigawa, T., Watanabe, T., Hamaguchi, M., Sasaki, E., Tominaga, K., Fujiwara, Y., Oshitani, N., Matsumoto, T., Higuchi, K., and Arakawa, T. (2004). Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G148-G156.
29. Tao, L. L., Cheng, Y. Y., Ding, D., Mei, S., Xu, J. W., Yu, J., Ou-Yang, Q., Deng, L., Chen, Q., Li, Q. Q., et al. (2012). C/EBP-alpha ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo. Apoptosis 17, 492-502.
30. Wang, D., and Dubois, R. N. (2006). Prostaglandins and cancer. Gut 55, 115-122.
31. Wu, B., Zeng, L., Lin, Y., Wen, Z., Chen, G., Iwakiri, R., and Fujimoto, K. (2009). Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats. Cell Res. 19, 1269-1278.
32. Xiao, J., Liong, E. C., Ching, Y. P., Chang, R. C., So, K. F., Fung, M. L., and Tipoe, G. L. (2012a). Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J. Ethnopharmacol. 139, 462-470.
33. Xiao, J., Liong, E. C., Ling, M. T., Ching, Y. P., Fung, M. L., and Tipoe, G. L. (2012b). S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice. Eur. J. Nutr. 51, 323-333.
34. Yang, S. L., Huang, X., Chen, H. F., Xu, D., Chen, L. J., Kong, Y., and Lou, Y. J. (2007). Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. J. Surg. Res. 140, 36-44.