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Volumn 75, Issue , 2015, Pages 201-209

Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix

Author keywords

Cbl; Osteoblast differentiation; Osterix; Ubiquitination

Indexed keywords

CBL PROTEIN; PROTEIN CBL B; TRANSCRIPTION FACTOR OSTERIX; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CBLB PROTEIN, MOUSE; OSTERIX PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

EID: 84924702605     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.02.026     Document Type: Article
Times cited : (28)

References (52)
  • 1
    • 0036090228 scopus 로고    scopus 로고
    • Regulatory mechanisms of osteoblast and osteoclast differentiation
    • Katagiri T., Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 2002, 8:147-159.
    • (2002) Oral Dis , vol.8 , pp. 147-159
    • Katagiri, T.1    Takahashi, N.2
  • 2
    • 47749102180 scopus 로고    scopus 로고
    • Differentiation of osteoblasts and osteocytes from mesenchymal stem cells
    • Heino T.J., Hentunen T.A. Differentiation of osteoblasts and osteocytes from mesenchymal stem cells. Curr Stem Cell Res Ther 2008, 3:131-145.
    • (2008) Curr Stem Cell Res Ther , vol.3 , pp. 131-145
    • Heino, T.J.1    Hentunen, T.A.2
  • 4
    • 0742306404 scopus 로고    scopus 로고
    • Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix
    • Blum B., Moseley J., Miller L., Richelsoph K., Haggard W. Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix. Orthopedics 2004, 27:s161-s165.
    • (2004) Orthopedics , vol.27 , pp. s161-s165
    • Blum, B.1    Moseley, J.2    Miller, L.3    Richelsoph, K.4    Haggard, W.5
  • 5
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • Yamaguchi A., Komori T., Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 2000, 21:393-411.
    • (2000) Endocr Rev , vol.21 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 6
    • 40349111202 scopus 로고    scopus 로고
    • Osteoblast differentiation induced by BMP signaling and Runx2 through Cbfb regulation
    • Ohba S., Chung U.I., Tei Y. Osteoblast differentiation induced by BMP signaling and Runx2 through Cbfb regulation. Nihon Rinsho 2007, 65(Suppl. 9):71-74.
    • (2007) Nihon Rinsho , vol.65 , pp. 71-74
    • Ohba, S.1    Chung, U.I.2    Tei, Y.3
  • 7
    • 57649231166 scopus 로고    scopus 로고
    • BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation
    • Matsubara T., Kida K., Yamaguchi A., Hata K., Ichida F., Meguro H., et al. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 2008, 283:29119-29125.
    • (2008) J Biol Chem , vol.283 , pp. 29119-29125
    • Matsubara, T.1    Kida, K.2    Yamaguchi, A.3    Hata, K.4    Ichida, F.5    Meguro, H.6
  • 8
    • 42949101521 scopus 로고    scopus 로고
    • BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38
    • Ulsamer A., Ortuno M.J., Ruiz S., Susperregui A.R., Osses N., Rosa J.L., et al. BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. J Biol Chem 2008, 283:3816-3826.
    • (2008) J Biol Chem , vol.283 , pp. 3816-3826
    • Ulsamer, A.1    Ortuno, M.J.2    Ruiz, S.3    Susperregui, A.R.4    Osses, N.5    Rosa, J.L.6
  • 9
    • 33751197049 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation by transcription factors
    • Komori T. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 2006, 99:1233-1239.
    • (2006) J Cell Biochem , vol.99 , pp. 1233-1239
    • Komori, T.1
  • 10
    • 0041328856 scopus 로고    scopus 로고
    • BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2
    • Lee M.H., Kwon T.G., Park H.S., Wozney J.M., Ryoo H.M. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun 2003, 309:689-694.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 689-694
    • Lee, M.H.1    Kwon, T.G.2    Park, H.S.3    Wozney, J.M.4    Ryoo, H.M.5
  • 11
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 12
    • 0034682072 scopus 로고    scopus 로고
    • Roles for Msx and Dlx homeoproteins in vertebrate development
    • Bendall A.J., Abate-Shen C. Roles for Msx and Dlx homeoproteins in vertebrate development. Gene 2000, 247:17-31.
    • (2000) Gene , vol.247 , pp. 17-31
    • Bendall, A.J.1    Abate-Shen, C.2
  • 13
    • 4744340414 scopus 로고    scopus 로고
    • Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    • Hassan M.Q., Javed A., Morasso M.I., Karlin J., Montecino M., van Wijnen A.J., et al. Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol. Cell. Biol. 2004, 24:9248-9261.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9248-9261
    • Hassan, M.Q.1    Javed, A.2    Morasso, M.I.3    Karlin, J.4    Montecino, M.5    van Wijnen, A.J.6
  • 14
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002, 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6
  • 16
    • 36048967549 scopus 로고    scopus 로고
    • Osteoblast differentiation in vitro and in vivo promoted by Osterix
    • Fu H., Doll B., McNelis T., Hollinger J.O. Osteoblast differentiation in vitro and in vivo promoted by Osterix. J Biomed Mater Res A 2007, 83:770-778.
    • (2007) J Biomed Mater Res A , vol.83 , pp. 770-778
    • Fu, H.1    Doll, B.2    McNelis, T.3    Hollinger, J.O.4
  • 17
    • 32344432473 scopus 로고    scopus 로고
    • Osterix enhances proliferation and osteogenic potential of bone marrow stromal cells
    • Tu Q., Valverde P., Chen J. Osterix enhances proliferation and osteogenic potential of bone marrow stromal cells. Biochem Biophys Res Commun 2006, 341:1257-1265.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 1257-1265
    • Tu, Q.1    Valverde, P.2    Chen, J.3
  • 18
    • 32044471655 scopus 로고    scopus 로고
    • The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells
    • Kim Y.J., Kim H.N., Park E.K., Lee B.H., Ryoo H.M., Kim S.Y., et al. The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. Gene 2006, 366:145-151.
    • (2006) Gene , vol.366 , pp. 145-151
    • Kim, Y.J.1    Kim, H.N.2    Park, E.K.3    Lee, B.H.4    Ryoo, H.M.5    Kim, S.Y.6
  • 19
    • 33644947390 scopus 로고    scopus 로고
    • Molecular characterization of the zinc finger transcription factor, Osterix
    • Hatta M., Yoshimura Y., Deyama Y., Fukamizu A., Suzuki K. Molecular characterization of the zinc finger transcription factor, Osterix. Int J Mol Med 2006, 17:425-430.
    • (2006) Int J Mol Med , vol.17 , pp. 425-430
    • Hatta, M.1    Yoshimura, Y.2    Deyama, Y.3    Fukamizu, A.4    Suzuki, K.5
  • 20
    • 44349125905 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix
    • Zhang C., Cho K., Huang Y., Lyons J.P., Zhou X., Sinha K., et al. Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 2008, 105:6936-6941.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6936-6941
    • Zhang, C.1    Cho, K.2    Huang, Y.3    Lyons, J.P.4    Zhou, X.5    Sinha, K.6
  • 21
    • 4344624316 scopus 로고    scopus 로고
    • Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation
    • Kaabeche K., Lemonnier J., Le Mee S., Caverzasio J., Marie P.J. Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem 2004, 279:36259-36267.
    • (2004) J Biol Chem , vol.279 , pp. 36259-36267
    • Kaabeche, K.1    Lemonnier, J.2    Le Mee, S.3    Caverzasio, J.4    Marie, P.J.5
  • 22
    • 79959908795 scopus 로고    scopus 로고
    • The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination
    • Severe N., Miraoui H., Marie P.J. The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. J Biol Chem 2011, 286:24443-24450.
    • (2011) J Biol Chem , vol.286 , pp. 24443-24450
    • Severe, N.1    Miraoui, H.2    Marie, P.J.3
  • 23
    • 82755182581 scopus 로고    scopus 로고
    • Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation
    • Brennan T., Adapala N.S., Barbe M.F., Yingling V., Sanjay A. Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation. Calcif Tissue Int 2011, 89:396-410.
    • (2011) Calcif Tissue Int , vol.89 , pp. 396-410
    • Brennan, T.1    Adapala, N.S.2    Barbe, M.F.3    Yingling, V.4    Sanjay, A.5
  • 24
    • 38849132555 scopus 로고    scopus 로고
    • Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation
    • Guenou H., Kaabeche K., Dufour C., Miraoui H., Marie P.J. Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation. Am J Pathol 2006, 169:1303-1311.
    • (2006) Am J Pathol , vol.169 , pp. 1303-1311
    • Guenou, H.1    Kaabeche, K.2    Dufour, C.3    Miraoui, H.4    Marie, P.J.5
  • 25
    • 84879936071 scopus 로고    scopus 로고
    • Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity
    • Dieudonne F.X., Severe N., Biosse-Duplan M., Weng J.J., Su Y., Marie P.J. Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity. Stem Cells 2013, 31:1340-1349.
    • (2013) Stem Cells , vol.31 , pp. 1340-1349
    • Dieudonne, F.X.1    Severe, N.2    Biosse-Duplan, M.3    Weng, J.J.4    Su, Y.5    Marie, P.J.6
  • 26
    • 33646227897 scopus 로고    scopus 로고
    • Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation
    • Suzue N., Nikawa T., Onishi Y., Yamada C., Hirasaka K., Ogawa T., et al. Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation. J Bone Miner Res 2006, 21:722-734.
    • (2006) J Bone Miner Res , vol.21 , pp. 722-734
    • Suzue, N.1    Nikawa, T.2    Onishi, Y.3    Yamada, C.4    Hirasaka, K.5    Ogawa, T.6
  • 27
    • 78449236806 scopus 로고    scopus 로고
    • The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival
    • Adapala N.S., Barbe M.F., Langdon W.Y., Nakamura M.C., Tsygankov A.Y., Sanjay A. The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. J Biol Chem 2010, 285:36745-36758.
    • (2010) J Biol Chem , vol.285 , pp. 36745-36758
    • Adapala, N.S.1    Barbe, M.F.2    Langdon, W.Y.3    Nakamura, M.C.4    Tsygankov, A.Y.5    Sanjay, A.6
  • 29
    • 0347263933 scopus 로고    scopus 로고
    • The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction
    • Lupher M.L., Rao N., Eck M.J., Band H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol Today 1999, 20:375-382.
    • (1999) Immunol Today , vol.20 , pp. 375-382
    • Lupher, M.L.1    Rao, N.2    Eck, M.J.3    Band, H.4
  • 30
    • 0035316576 scopus 로고    scopus 로고
    • Cbl: many adaptations to regulate protein tyrosine kinases
    • Thien C.B., Langdon W.Y. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001, 2:294-307.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 294-307
    • Thien, C.B.1    Langdon, W.Y.2
  • 31
    • 27444445613 scopus 로고    scopus 로고
    • C-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses
    • Thien C.B., Langdon W.Y. c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses. Biochem J 2005, 391:153-166.
    • (2005) Biochem J , vol.391 , pp. 153-166
    • Thien, C.B.1    Langdon, W.Y.2
  • 32
    • 84872202144 scopus 로고    scopus 로고
    • E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis
    • Severe N., Dieudonne F.X., Marie P.J. E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis. Cell Death Dis 2013, 4:e463.
    • (2013) Cell Death Dis , vol.4 , pp. e463
    • Severe, N.1    Dieudonne, F.X.2    Marie, P.J.3
  • 33
    • 24944538477 scopus 로고    scopus 로고
    • Negative regulation of PTK signalling by Cbl proteins
    • Thien C.B., Langdon W.Y. Negative regulation of PTK signalling by Cbl proteins. Growth Factors 2005, 23:161-167.
    • (2005) Growth Factors , vol.23 , pp. 161-167
    • Thien, C.B.1    Langdon, W.Y.2
  • 34
    • 0037151106 scopus 로고    scopus 로고
    • A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1
    • Sasaki A., Masuda Y., Iwai K., Ikeda K., Watanabe K. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem 2002, 277:22541-22546.
    • (2002) J Biol Chem , vol.277 , pp. 22541-22546
    • Sasaki, A.1    Masuda, Y.2    Iwai, K.3    Ikeda, K.4    Watanabe, K.5
  • 35
    • 77954582429 scopus 로고    scopus 로고
    • Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines
    • Salingcarnboriboon R.A., Pavasant P., Noda M. Cbl-b enhances Runx2 protein stability and augments osteocalcin promoter activity in osteoblastic cell lines. J Cell Physiol 2010, 224:743-747.
    • (2010) J Cell Physiol , vol.224 , pp. 743-747
    • Salingcarnboriboon, R.A.1    Pavasant, P.2    Noda, M.3
  • 36
    • 0026609904 scopus 로고
    • Ubiquitin-dependent degradation and modification of proteins
    • von Kampen J., Wettern M. Ubiquitin-dependent degradation and modification of proteins. Naturwissenschaften 1992, 79:163-170.
    • (1992) Naturwissenschaften , vol.79 , pp. 163-170
    • von Kampen, J.1    Wettern, M.2
  • 37
    • 0035860713 scopus 로고    scopus 로고
    • Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins
    • Yokouchi M., Kondo T., Sanjay A., Houghton A., Yoshimura A., Komiya S., et al. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J Biol Chem 2001, 276:35185-35193.
    • (2001) J Biol Chem , vol.276 , pp. 35185-35193
    • Yokouchi, M.1    Kondo, T.2    Sanjay, A.3    Houghton, A.4    Yoshimura, A.5    Komiya, S.6
  • 38
    • 0032567438 scopus 로고    scopus 로고
    • Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
    • Lupher M.L., Rao N., Lill N.L., Andoniou C.E., Miyake S., Clark E.A., et al. Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. J Biol Chem 1998, 273:35273-35281.
    • (1998) J Biol Chem , vol.273 , pp. 35273-35281
    • Lupher, M.L.1    Rao, N.2    Lill, N.L.3    Andoniou, C.E.4    Miyake, S.5    Clark, E.A.6
  • 41
    • 43149123990 scopus 로고    scopus 로고
    • FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival
    • Dufour C., Guenou H., Kaabeche K., Bouvard D., Sanjay A., Marie P.J. FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone 2008, 42:1032-1039.
    • (2008) Bone , vol.42 , pp. 1032-1039
    • Dufour, C.1    Guenou, H.2    Kaabeche, K.3    Bouvard, D.4    Sanjay, A.5    Marie, P.J.6
  • 42
    • 84872202144 scopus 로고    scopus 로고
    • E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis
    • Severe N., Dieudonne F.X., Marie P.J. E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis. Cell Death Dis 2013, 4.
    • (2013) Cell Death Dis , vol.4
    • Severe, N.1    Dieudonne, F.X.2    Marie, P.J.3
  • 43
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P., Montgomery C., Geske R., Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991, 64:693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 44
    • 0036915314 scopus 로고    scopus 로고
    • An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn
    • Rao N., Ghosh A.K., Douillard P., Andoniou C.E., Zhou P., Band H. An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn. Signal Transduct 2002, 2:29-39.
    • (2002) Signal Transduct , vol.2 , pp. 29-39
    • Rao, N.1    Ghosh, A.K.2    Douillard, P.3    Andoniou, C.E.4    Zhou, P.5    Band, H.6
  • 45
    • 28544451132 scopus 로고    scopus 로고
    • The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
    • Horne W.C., Sanjay A., Bruzzaniti A., Baron R. The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function. Immunol Rev 2005, 208:106-125.
    • (2005) Immunol Rev , vol.208 , pp. 106-125
    • Horne, W.C.1    Sanjay, A.2    Bruzzaniti, A.3    Baron, R.4
  • 46
    • 77949330986 scopus 로고    scopus 로고
    • Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1
    • Kim J.H., Kim K., Jin H.M., Song I., Youn B.U., Lee S.H., et al. Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1. J Biol Chem 2010, 285:5224-5231.
    • (2010) J Biol Chem , vol.285 , pp. 5224-5231
    • Kim, J.H.1    Kim, K.2    Jin, H.M.3    Song, I.4    Youn, B.U.5    Lee, S.H.6
  • 47
    • 0033598173 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of active Src
    • Hakak Y., Martin G.S. Ubiquitin-dependent degradation of active Src. Curr Biol 1999, 9:1039-1042.
    • (1999) Curr Biol , vol.9 , pp. 1039-1042
    • Hakak, Y.1    Martin, G.S.2
  • 48
    • 0032866076 scopus 로고    scopus 로고
    • Cas mediates transcriptional activation of the serum response element by Src
    • Hakak Y., Martin G.S. Cas mediates transcriptional activation of the serum response element by Src. Mol. Cell. Biol. 1999, 19:6953-6962.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6953-6962
    • Hakak, Y.1    Martin, G.S.2
  • 49
    • 0035825121 scopus 로고    scopus 로고
    • Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
    • Sanjay A., Houghton A., Neff L., DiDomenico E., Bardelay C., Antoine E., et al. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol 2001, 152:181-195.
    • (2001) J Cell Biol , vol.152 , pp. 181-195
    • Sanjay, A.1    Houghton, A.2    Neff, L.3    DiDomenico, E.4    Bardelay, C.5    Antoine, E.6
  • 50
    • 0029043786 scopus 로고
    • Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways
    • Tanaka S., Neff L., Baron R., Levy J.B. Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem 1995, 270:14347-14351.
    • (1995) J Biol Chem , vol.270 , pp. 14347-14351
    • Tanaka, S.1    Neff, L.2    Baron, R.3    Levy, J.B.4
  • 51
    • 0037067728 scopus 로고    scopus 로고
    • Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor
    • Kassenbrock C.K., Hunter S., Garl P., Johnson G.L., Anderson S.M. Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem 2002, 277:24967-24975.
    • (2002) J Biol Chem , vol.277 , pp. 24967-24975
    • Kassenbrock, C.K.1    Hunter, S.2    Garl, P.3    Johnson, G.L.4    Anderson, S.M.5
  • 52
    • 84866668120 scopus 로고    scopus 로고
    • Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis
    • Severe N., Dieudonne F.X., Marty C., Modrowski D., Patino-Garcia A., Lecanda F., et al. Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesis. J Bone Miner Res 2012, 27:2108-2117.
    • (2012) J Bone Miner Res , vol.27 , pp. 2108-2117
    • Severe, N.1    Dieudonne, F.X.2    Marty, C.3    Modrowski, D.4    Patino-Garcia, A.5    Lecanda, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.