Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway

Journal of Pineal Research

Volumn 58, Issue 3, 2015, Pages 321-334

  Zhang, Yuan ^a,b   Li, Hua ^c   Pu, Yicheng ^a   Gong, Shan ^a   Liu, Chunfeng ^b   Jiang, Xinghong ^a   Tao, Jin ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c National Shanghai Center for New Drug Safety Evaluation and Research   (China)

Author keywords

melatonin; P type calcium channel; protein kinase C; Purkinje neuron

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C DELTA;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CEREBELLUM CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOREACTIVITY; IN VITRO STUDY; INTRACELLULAR SIGNALING; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PROTEIN EXPRESSION; PURKINJE CELL; RAT; STEADY STATE; ANIMAL; DRUG EFFECTS; METABOLISM; WISTAR RAT;

ANIMALS; CALCIUM CHANNELS, P-TYPE; MELATONIN; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE C-DELTA; PURKINJE CELLS; RATS; RATS, WISTAR;

EID: 84924701200     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12218     Document Type: Article

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