Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells

Life Sciences

Volumn 127, Issue , 2015, Pages 66-72

  Dai, Peimin ^a,b   Zhu, Lijun ^a   Yang, Xiaoshan ^a   Zhao, Min ^a   Shi, Jian ^a,b   Wang, Ying ^a,b   Lu, Linlin ^a   Liu, Zhongqiu ^a,b  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Aconitum alkaloids; Efflux transporters; MRP2 MDCKII cell; Multidrug resistance associated protein 2

Indexed keywords

ACONINE; ACONITINE; ALKALOID DERIVATIVE; BENZOYLACONINE; BENZOYLHYPACONINE; BENZOYLMESACONINE; BREAST CANCER RESISTANCE PROTEIN; HYPACONINE; HYPACONITINE; MESACONINE; MESACONITINE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; ABCB1 PROTEIN, HUMAN; ALKALOID; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2;

ACONITE; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; HUMAN; MDCK CELL LINE; PROTEIN EXPRESSION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOG; DRUG EFFECTS; GENETIC TRANSFECTION; METABOLISM;

ACONITUM;

ACONITUM; ALKALOIDS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; DOGS; HUMANS; LEUKOTRIENE C4; MADIN DARBY CANINE KIDNEY CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; TRANSFECTION;

EID: 84924690420     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.02.011     Document Type: Article

References (27)

1. S.G. Aller, J. Yu, A. Ward, Y. Weng, S. Chittaboina, and R. Zhuo Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science (New York, N.Y.) 323 2009 1718 1722
2. A. Ameri The effects of Aconitum alkaloids on the central nervous system Prog. Neurobiol. 56 1998 211 235
3. N.G. Bisset Arrow poisons in China. Part II. Aconitum-botany, chemistry, and pharmacology J. Ethnopharmacol. 4 1981 247 336
4. T.Y. Chan Aconite poisoning presenting as hypotension and bradycardia Hum. Exp. Toxicol. 28 2009 795 797
5. M.M. Doherty, and W.N. Charman The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet. 41 2002 235 253
6. U.T. Gutser, J. Friese, J.F. Heubach, T. Matthiesen, N. Selve, and B. Wilffert Mode of antinociceptive and toxic action of alkaloids of Aconitum spec Naunyn Schmiedeberg's Arch. Pharmacol. 357 1998 39 48
7. Q.A. Huang, Y.M. Zhang, Y. He, J. Lu, and R.C. Lin Studies on hydrolysis of aconitine Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med. 32 2007 2143 2145
8. M. Kobayashi, H. Takahashi, D.N. Herndon, R.B. Pollard, and F. Suzuki Therapeutic effects of IL-12 combined with benzoylmesaconine, a non-toxic aconitine-hydrolysate, against herpes simplex virus type 1 infection in mice following thermal injury Burns 29 2003 37 42
9. C.C. Lin, T.Y. Chan, and J.F. Deng Clinical features and management of herb-induced aconitine poisoning Ann. Emerg. Med. 43 2004 574 579
10. Q. Liu, L. Zhuo, L. Liu, S. Zhu, A. Sunnassee, and M. Liang Seven cases of fatal aconite poisoning: forensic experience in China Forensic Sci. Int. 212 2011 e5 e9
11. K. Mease, R. Sane, L. Podila, and M.E. Taub Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2 J. Pharm. Sci. 101 2012 1888 1897
12. R. Pullela, L. Young, B. Gallagher, S.P. Avis, and E.W. Randell A case of fatal aconitine poisoning by Monkshood ingestion J. Forensic Sci. 53 2008 491 494
13. H. Sato, C. Yamada, C. Konno, Y. Ohizumi, K. Endo, and H. Hikino Pharmacological actions of aconitine alkaloids Tohoku J. Exp. Med. 128 1979 175 187
14. J. Singhuber, M. Zhu, S. Prinz, and B. Kopp Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? J. Ethnopharmacol. 126 2009 18 30
15. Y. Suzuki, Y. Hayakawa, T. Oyama, T. Isono, Y. Ohmiya, and Y. Ikeda Analgesic effect of benzoylmesaconine Nihon Yakurigaku Zasshi Folia Pharmacol. Jap. 102 1993 399 404
16. Y. Suzuki, T. Oyama, A. Ishige, T. Isono, A. Asami, and Y. Ikeda Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine Planta Med. 60 1994 391 394
17. J. Taipalensuu, H. Tornblom, G. Lindberg, C. Einarsson, F. Sjoqvist, and H. Melhus Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers J. Pharmacol. Exp. Ther. 299 2001 164 170
18. L. Tang, Y. Gong, C. Lv, L. Ye, L. Liu, and Z. Liu Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS J. Ethnopharmacol. 141 2012 736 741
19. T. Tazawa, H.Q. Zhao, Y. Li, M.R. Meselhy, N. Nakamura, and T. Akao A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma Biol. Pharm. Bull. 26 2003 1289 1294
20. A.A. Van Landeghem, E.A. De Letter, W.E. Lambert, C.H. Van Peteghem, and M.H. Piette Aconitine involvement in an unusual homicide case Int. J. Legal Med. 121 2007 214 219
21. C. Yang, Z. Li, T. Zhang, F. Liu, J. Ruan, and Z. Zhang Transcellular transport of aconitine across human intestinal Caco-2 cells Food Chem. Toxicol. 57 2013 195 200
22. C. Yang, T. Zhang, Z. Li, L. Xu, F. Liu, and J. Ruan P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies Toxicol. Appl. Pharmacol. 273 2013 561 568
23. Z. Yang, S. Gao, J. Wang, T. Yin, Y. Teng, and B. Wu Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms Drug Metab. Dispos. 39 2011 1866 1872
24. L. Ye, S. Gao, Q. Feng, W. Liu, Z. Yang, and M. Hu Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine Xenobiotica 42 2012 518 525
25. L. Ye, L. Tang, Y. Gong, C. Lv, Z. Zheng, and Z. Jiang Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine Xenobiotica 41 2011 46 58
26. L. Ye, X. Yang, E. Guo, W. Chen, L. Lu, and Y. Wang Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient PLoS One 9 2014 e96664
27. L. Ye, X. Yang, Z. Yang, S. Gao, T. Yin, and W. Liu The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells Toxicol. Lett. 216 2013 86 99