메뉴 건너뛰기




Volumn 16, Issue 2, 2015, Pages 297-306

PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism

Author keywords

CCL2; Co culture; NHERF 1; PTEN; TAM; Transformation

Indexed keywords

MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SHORT HAIRPIN RNA; SODIUM HYDROGEN EXCHANGER REGULATING FACTOR 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; PHOSPHOPROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

EID: 84924618022     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2014.1002353     Document Type: Article
Times cited : (69)

References (34)
  • 1
    • 0035993208 scopus 로고    scopus 로고
    • Tumor-associated macrophages: A molecular perspective
    • PMID:12349942
    • Sica A, Saccani A, Mantovani A. Tumor-associated macrophages: a molecular perspective. Int Immunopharmacol 2002; 2:1045-54; PMID:12349942; http://dx.doi.org/10.1016/S1567-5769(02)00064-4
    • (2002) Int Immunopharmacol , vol.2 , pp. 1045-1054
    • Sica, A.1    Saccani, A.2    Mantovani, A.3
  • 2
    • 36148960830 scopus 로고    scopus 로고
    • Inflammatory cell infiltration of tumors: Jekyll or Hyde
    • PMID:17717638
    • Talmadge JE, Donkor M, Scholar E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metast Rev 2007; 26:373-400; PMID:17717638; http://dx.doi.org/10.1007/s10555-007-9072-0
    • (2007) Cancer Metast Rev , vol.26 , pp. 373-400
    • Talmadge, J.E.1    Donkor, M.2    Scholar, E.3
  • 3
    • 77953284681 scopus 로고    scopus 로고
    • Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages
    • PMID:20386569
    • Wang Q, Ni H, Lan L, Wei X, Xiang R, Wang Y. Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. Cell Res 2010; 20:701-12; PMID:20386569; http://dx.doi.org/10.1038/cr.2010.52
    • (2010) Cell Res , vol.20 , pp. 701-712
    • Wang, Q.1    Ni, H.2    Lan, L.3    Wei, X.4    Xiang, R.5    Wang, Y.6
  • 4
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • PMID:9072974
    • Li J. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-7; PMID:9072974; http://dx.doi.org/10.1126/science.275.5308.1943
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1
  • 5
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • PMID:9090379
    • Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-62; PMID:9090379; http://dx.doi.org/10.1038/ng0497-356
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3    Yung, W.K.4    Lin, H.5    Ligon, A.H.6    Langford, L.A.7    Baumgard, M.L.8    Hattier, T.9    Davis, T.10
  • 6
    • 79960050610 scopus 로고    scopus 로고
    • PTEN tumor suppressor network in PI3K-Akt pathway control
    • PMID:21779440
    • Georgescu MM. PTEN tumor suppressor network in PI3K-Akt pathway control. Genes Cancer 2010;1:1170-7; PMID:21779440; http://dx.doi.org/10.1177/1947601911407325
    • (2010) Genes Cancer , vol.1 , pp. 1170-1177
    • Georgescu, M.M.1
  • 7
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • PMID:15728109
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005; 16:525-37; PMID:15728109; http://dx.doi.org/10.1093/annonc/mdi113
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 8
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • PMID:9616126
    • Tamura M. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998; 280:1614-7; PMID:9616126; http://dx.doi.org/10.1126/science.280.5369.1614
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1
  • 9
    • 84884197563 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma
    • PMID:24047437
    • Hsu CJ, Wu MH, Chen CY, Tsai CH, Hsu HC, Tang CH. AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma. Cell Commun Signal 2013; 11:68-83; PMID:24047437; http://dx.doi.org/10.1186/1478-811X-11-68
    • (2013) Cell Commun Signal , vol.11 , pp. 68-83
    • Hsu, C.J.1    Wu, M.H.2    Chen, C.Y.3    Tsai, C.H.4    Hsu, H.C.5    Tang, C.H.6
  • 10
    • 84861882582 scopus 로고    scopus 로고
    • CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
    • PMID:22472119
    • Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S, Luu T, Li AX, Wu X, Ye W, et al. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res 2012; 72:2768-79; PMID:22472119; http://dx.doi.org/10.1158/0008-5472.CAN-11-3567
    • (2012) Cancer Res , vol.72 , pp. 2768-2779
    • Tsuyada, A.1    Chow, A.2    Wu, J.3    Somlo, G.4    Chu, P.5    Loera, S.6    Luu, T.7    Li, A.X.8    Wu, X.9    Ye, W.10
  • 11
    • 77549086214 scopus 로고    scopus 로고
    • CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis
    • PMID:20005149
    • Zhang J, Patel L, Pienta KJ. CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis. Cytokine Growth Factor Rev 2010; 21:41-8; PMID:20005149; http://dx.doi.org/10.1016/j.cytogfr.2009.11.009
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 41-48
    • Zhang, J.1    Patel, L.2    Pienta, K.J.3
  • 12
    • 84894288399 scopus 로고    scopus 로고
    • Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression
    • PMID:24503185
    • Tarassishin L, Lim J, Weatherly DB, Angeletti RH, Lee SC. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. J Proteomics 2014; 99:152-68; PMID:24503185; http://dx.doi.org/10.1016/j.jprot.2014.01.024
    • (2014) J Proteomics , vol.99 , pp. 152-168
    • Tarassishin, L.1    Lim, J.2    Weatherly, D.B.3    Angeletti, R.H.4    Lee, S.C.5
  • 13
    • 84897442586 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-beta signaling to drive malignant progression
    • PMID:24520074
    • Ohnuki H, Jiang K, Wang D, Salvucci O, Kwak H, Sanchez-Martin D, Maric D, Tosato G. Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-beta signaling to drive malignant progression. Cancer Res 2014; 74:2038-49; PMID:24520074; http://dx.doi.org/10.1158/0008-5472.CAN-13-3118
    • (2014) Cancer Res , vol.74 , pp. 2038-2049
    • Ohnuki, H.1    Jiang, K.2    Wang, D.3    Salvucci, O.4    Kwak, H.5    Sanchez-Martin, D.6    Maric, D.7    Tosato, G.8
  • 14
    • 84871261049 scopus 로고    scopus 로고
    • Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment
    • PMID:23272057
    • Bao B, Ali S, Ahmad A, Azmi AS, Li Y, Banerjee S, Kong D, Sethi S, Aboukameel A, Padhye SB, et al. Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment. PloS One 2012; 7:e50165; PMID:23272057; http://dx.doi.org/10.1371/journal.pone.0050165
    • (2012) PloS One , vol.7 , pp. e50165
    • Bao, B.1    Ali, S.2    Ahmad, A.3    Azmi, A.S.4    Li, Y.5    Banerjee, S.6    Kong, D.7    Sethi, S.8    Aboukameel, A.9    Padhye, S.B.10
  • 15
    • 84872065517 scopus 로고    scopus 로고
    • Autocrine functions of VEGF in breast tumor cells: Adhesion, survival, migration and invasion
    • PMID:23257828
    • Perrot-Applanat M, Di Benedetto M. Autocrine functions of VEGF in breast tumor cells: adhesion, survival, migration and invasion. Cell Adhesion Migr 2012;6:547-53; PMID:23257828; http://dx.doi.org/10.4161/cam.23332
    • (2012) Cell Adhesion Migr , vol.6 , pp. 547-553
    • Perrot-Applanat, M.1    Di Benedetto, M.2
  • 16
    • 84891768695 scopus 로고    scopus 로고
    • M-CSF cooperating with NFkappaB induces macrophage transformation from M1 to M2 by upregulating c-Jun
    • PMID:24100343
    • Yang Y, Qin J, Lan L, Li N, Wang C, He P, Liu F, Ni H, Wang Y. M-CSF cooperating with NFkappaB induces macrophage transformation from M1 to M2 by upregulating c-Jun. Cancer Biol Ther 2014; 15:99-107; PMID:24100343; http://dx.doi.org/10.4161/cbt.26718
    • (2014) Cancer Biol Ther , vol.15 , pp. 99-107
    • Yang, Y.1    Qin, J.2    Lan, L.3    Li, N.4    Wang, C.5    He, P.6    Liu, F.7    Ni, H.8    Wang, Y.9
  • 17
    • 37849036848 scopus 로고    scopus 로고
    • Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes
    • PMID:18069890
    • Davis AS, Vergne I, Master SS, Kyei GB, Chua J, Deretic V. Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes. PLoS Pathog 2007; 3: e186; PMID:18069890; http://dx.doi.org/10.1371/journal.ppat.0030186
    • (2007) PLoS Pathog , vol.3 , pp. e186
    • Davis, A.S.1    Vergne, I.2    Master, S.S.3    Kyei, G.B.4    Chua, J.5    Deretic, V.6
  • 18
    • 34347241756 scopus 로고    scopus 로고
    • Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells
    • PMID:17545592
    • Cheng J, Huo DH, Kuang DM, Yang J, Zheng L, Zhuang SM. Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells. Cancer Res 2007; 67:5141-7; PMID:17545592; http://dx.doi.org/10.1158/0008-5472.CAN-06-4763
    • (2007) Cancer Res , vol.67 , pp. 5141-5147
    • Cheng, J.1    Huo, D.H.2    Kuang, D.M.3    Yang, J.4    Zheng, L.5    Zhuang, S.M.6
  • 19
    • 84863797648 scopus 로고    scopus 로고
    • Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
    • PMID:22037217
    • Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind JS, Waes CV, Kulkarni AB. Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene 2012; 31:3322-32; PMID:22037217; http://dx.doi.org/10.1038/onc.2011.494
    • (2012) Oncogene , vol.31 , pp. 3322-3332
    • Bian, Y.1    Hall, B.2    Sun, Z.J.3    Molinolo, A.4    Chen, W.5    Gutkind, J.S.6    Waes, C.V.7    Kulkarni, A.B.8
  • 20
    • 84858003974 scopus 로고    scopus 로고
    • PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
    • PMID:21804599
    • Molina JR, Agarwal NK, Morales FC, Hayashi Y, Aldape KD, Cote G, Georgescu MM. PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene 2012;31:1264-74; PMID:21804599; http://dx.doi.org/10.1038/onc.2011.324
    • (2012) Oncogene , vol.31 , pp. 1264-1274
    • Molina, J.R.1    Agarwal, N.K.2    Morales, F.C.3    Hayashi, Y.4    Aldape, K.D.5    Cote, G.6    Georgescu, M.M.7
  • 21
    • 33644504867 scopus 로고    scopus 로고
    • PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
    • PMID:16456542
    • Takahashi Y, Morales FC, Kreimann EL, Georgescu MM. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 2006; 25:910-20; PMID:16456542; http://dx.doi.org/10.1038/sj.emboj.7600979
    • (2006) EMBO J , vol.25 , pp. 910-920
    • Takahashi, Y.1    Morales, F.C.2    Kreimann, E.L.3    Georgescu, M.M.4
  • 22
    • 77956288767 scopus 로고    scopus 로고
    • Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
    • PMID:20736378
    • Molina JR, Morales FC, Hayashi Y, Aldape KD, Georgescu MM. Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation. Cancer Res 2010;70:6697-703; PMID:20736378; http://dx.doi.org/10.1158/0008-5472.CAN-10-1271
    • (2010) Cancer Res , vol.70 , pp. 6697-6703
    • Molina, J.R.1    Morales, F.C.2    Hayashi, Y.3    Aldape, K.D.4    Georgescu, M.M.5
  • 23
    • 0035966127 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
    • PMID:11707428
    • Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 2001;276:48627-30; PMID:11707428; http://dx.doi.org/10.1074/jbc.C100556200
    • (2001) J Biol Chem , vol.276 , pp. 48627-48630
    • Vazquez, F.1    Grossman, S.R.2    Takahashi, Y.3    Rokas, M.V.4    Nakamura, N.5    Sellers, W.R.6
  • 24
    • 84901716734 scopus 로고    scopus 로고
    • Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels
    • PMID:24561792
    • Gomes AM, Soares MV, Ribeiro P, Caldas J, Povoa V, Martins LR, Melão A, Serra-Caetano A, de Sousa AB, Lacerda JF, et al. Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels. Haematologica 2014;99:1062-8; PMID:24561792; http://dx.doi.org/10.3324/haematol.2013.096438
    • (2014) Haematologica , vol.99 , pp. 1062-1068
    • Gomes, A.M.1    Soares, M.V.2    Ribeiro, P.3    Caldas, J.4    Povoa, V.5    Martins, L.R.6    Melão, A.7    Serra-Caetano, A.8    De Sousa, A.B.9    Lacerda, J.F.10
  • 25
    • 0035863864 scopus 로고    scopus 로고
    • Signal transduction involved in MCP-1-mediated monocytic transendothelial migration
    • PMID:11154209
    • Cambien B. Signal transduction involved in MCP-1-mediated monocytic transendothelial migration. Blood 2001; 97:359-66; PMID:11154209; http://dx.doi.org/10.1182/blood.V97.2.359
    • (2001) Blood , vol.97 , pp. 359-366
    • Cambien, B.1
  • 26
    • 13244265590 scopus 로고    scopus 로고
    • Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
    • PMID:15543611
    • Pedrero JM, Carracedo DG, Pinto CM, Zapatero AH, Rodrigo JP, Nieto CS, Gonzalez MV. Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma. Int J Cancer J 2005; 114:242-8; PMID:15543611; http://dx.doi.org/10.1002/ijc.20711
    • (2005) Int J Cancer J , vol.114 , pp. 242-248
    • Pedrero, J.M.1    Carracedo, D.G.2    Pinto, C.M.3    Zapatero, A.H.4    Rodrigo, J.P.5    Nieto, C.S.6    Gonzalez, M.V.7
  • 27
    • 65549105393 scopus 로고    scopus 로고
    • Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: Systematic review and meta-analysis
    • PMID:19401698
    • Schoenleber SJ, Kurtz DM, Talwalkar JA, Roberts LR, Gores GJ. Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis. Br J Cancer 2009; 100:1385-92; PMID:19401698; http://dx.doi.org/10.1038/sj.bjc.6605017
    • (2009) Br J Cancer , vol.100 , pp. 1385-1392
    • Schoenleber, S.J.1    Kurtz, D.M.2    Talwalkar, J.A.3    Roberts, L.R.4    Gores, G.J.5
  • 28
    • 48949119476 scopus 로고    scopus 로고
    • NHERF1: Molecular brake on the PI3K pathway in breast cancer
    • PMID:18430260
    • Georgescu MM. NHERF1: molecular brake on the PI3K pathway in breast cancer. Breast Cancer Res 2008; 10:106-7; PMID:18430260; http://dx.doi.org/10.1186/bcr1992
    • (2008) Breast Cancer Res , vol.10 , pp. 106-107
    • Georgescu, M.M.1
  • 29
    • 34147206059 scopus 로고    scopus 로고
    • NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
    • PMID:17242191
    • Morales FC, Takahashi Y, Momin S, Adams H, Chen X, Georgescu MM. NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands. Mol Cell Biol 2007; 27:2527-37; PMID:17242191; http://dx.doi.org/10.1128/MCB.01372-06
    • (2007) Mol Cell Biol , vol.27 , pp. 2527-2537
    • Morales, F.C.1    Takahashi, Y.2    Momin, S.3    Adams, H.4    Chen, X.5    Georgescu, M.M.6
  • 30
    • 82355190887 scopus 로고    scopus 로고
    • Na(C)/H(C) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression
    • PMID:21990315
    • Yang L, Wang Y, Chen P, Hu J, Xiong Y, Feng D, Liu H, Zhang H, Yang H, He J. Na(C)/H(C) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression. Endocrinology 2011; 152:4537-49; PMID:21990315; http://dx.doi.org/10.1210/en.2011-1207
    • (2011) Endocrinology , vol.152 , pp. 4537-4549
    • Yang, L.1    Wang, Y.2    Chen, P.3    Hu, J.4    Xiong, Y.5    Feng, D.6    Liu, H.7    Zhang, H.8    Yang, H.9    He, J.10
  • 31
    • 44849096490 scopus 로고    scopus 로고
    • Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
    • PMID:18190691
    • + exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res 2008;10:R5; PMID:18190691; http://dx.doi.org/10.1186/bcr1846
    • (2008) Breast Cancer Res , vol.10 , pp. R5
    • Pan, Y.1    Weinman, E.J.2    Dai, J.L.3
  • 32
    • 53149090938 scopus 로고    scopus 로고
    • Roles of NHERF1/EBP50 in cancer
    • PMID:18781953
    • Georgescu MM, Morales FC, Molina JR, Hayashi Y. Roles of NHERF1/EBP50 in cancer. Curr Mol Med 2008; 8:459-68; PMID:18781953; http://dx.doi.org/10.2174/156652408785748031
    • (2008) Curr Mol Med , vol.8 , pp. 459-468
    • Georgescu, M.M.1    Morales, F.C.2    Molina, J.R.3    Hayashi, Y.4
  • 34
    • 84898912407 scopus 로고    scopus 로고
    • CCL2/ROS autoregulation loop is critical for cancer associated fibroblasts-enhanced tumor growth of oral
    • PMID:24531940
    • Li X, Xu Q, Wu Y, Qinqiao F. A CCL2/ROS autoregulation loop is critical for cancer associated fibroblasts-enhanced tumor growth of oral. Carcinogenesis 2014;35:1362-70; PMID:24531940; http://dx.doi.org/10.1093/carcin/bgu046
    • (2014) Carcinogenesis , vol.35 , pp. 1362-1370
    • Li, X.1    Xu, Q.2    Wu, Y.3    Qinqiao, F.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.