M-CSF cooperating with NFκB induces macrophage transformation from M1 to M2 by upregulating c-Jun

Cancer Biology and Therapy

Volumn 15, Issue 1, 2014, Pages 99-107

  Yang, Yujiao ^a   Qin, Junfang ^a   Lan, Lan ^a   Li, Ning ^b   Wang, Chengfang ^a   He, Pengfei ^a   Liu, Fang ^a   Ni, Hong ^a   Wang, Yue ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

C Jun; Co culture; M CSF; NF B; Transformation

Indexed keywords

COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE 1; NEUTRALIZING ANTIBODY; PROTEIN C FOS; PROTEIN C JUN; STAT6 PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; BREAST CANCER; CONTROLLED STUDY; IMMUNOBLOTTING; MACROPHAGE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TUMOR MICROENVIRONMENT; UPREGULATION;

C-JUN; CO-CULTURE; M-CSF; NFΚB; TRANSFORMATION;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COCULTURE TECHNIQUES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 84891768695     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.26718     Document Type: Article

References (29)

1. Kavitha CV, Deep G, Gangar SC, Jain AK, Agarwal C, Agarwal R. Silibinin inhibits prostate cancer cellsand RANKL-induced osteoclastogenesis by targeting NFATc1, NF-kB, and AP-1 Activation in RAW264.7 cells. Mol Carcinog 2012; http://dx.doi.org/10.1002/mc.21959; PMID:23115104
2. Stanley ER, Guilbert LJ, Tushinski RJ, Bartelmez SH. CSF-1-a mononuclear phagocyte lineagespecific hemopoietic growth factor. J Cell Biochem 1983; 21:151-9; PMID:6309875; http://dx.doi.org/10.1002/jcb.240210206 (Pubitemid 13008462)
3. Vesely PW, Staber PB, Hoefler G, Kenner L. Translational regulation mechanisms of AP-1 proteins. Mutat Res 2009; 682:7-12; PMID:19167516; http://dx.doi.org/10.1016/j.mrrev.2009.01.001
4. Edwards DR. Cell signalling and the control of gene transcription. Trends Pharmacol Sci 1994; 15:239-44; PMID:7940986; http://dx.doi.org/10.1016/0165- 6147(94)90318-2 (Pubitemid 24210729)
5. Wang Q, Ni H, Lan L, Wei X, Xiang R, Wang Y. Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. Cell Res 2010; 20:701-12; PMID:20386569; http://dx.doi.org/10.1038/ cr.2010.52
6. Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 2001; 193:727-40; PMID:11257139; http://dx.doi.org/10.1084/jem.193.6.727
7. Chambers SK. Role of CSF-1 in progression of epithelial ovarian cancer. Future Oncol 2009; 5:1429-40; PMID:19903070; http://dx.doi.org/10.2217/fon.09. 103
8. Kacinski BM. CSF-1 and its receptor in ovarian, endometrial and breast cancer. Ann Med 1995; 27:79-85; PMID:7742005; http://dx.doi.org/10.3109/ 07853899509031941
9. Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, Vaisberg E, Kastelein R, Kolk A, de Waal-Malefyt R, Ottenhoff TH. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc Natl Acad Sci U S A 2004; 101:4560-5; PMID:15070757; http://dx.doi.org/10.1073/pnas.0400983101 (Pubitemid 38437450)
10. Morandi A, Barbetti V, Riverso M, Dello Sbarba P, Rovida E. The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines. PLoS One 2011; 6:e27450; PMID:22096574; http://dx.doi.org/10.1371/journal.pone.0027450
11. Makarov SS. NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 2000; 6:441-8; PMID:11074370; http://dx.doi.org/10.1016/S1357-4310(00)01814-1
12. Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, Bottazzi B, Colombo MP, Mantovani A, Sica A. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 2006; 66:11432-40; PMID:17145890; http://dx.doi.org/10. 1158/0008-5472.CAN-06-1867 (Pubitemid 46009975)
13. Kovács KJ, Sawchenko PE. Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons. J Neurosci 1996; 16:262-73; PMID:8613792 (Pubitemid 26010715)
14. Larsen PJ, Mikkelsen JD. Functional identification of central afferent projections conveying information of acute "stress" to the hypothalamic paraventricular nucleus. J Neurosci 1995; 15:2609-27; PMID:7536817
15. Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood 2007; 110:4319-30; PMID:17848619; http://dx.doi.org/10.1182/blood- 2007-02-072587 (Pubitemid 351377797)
16. Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995; 81:1147-57; PMID:7600582; http://dx.doi.org/10.1016/ S0092-8674(05)80019-4
17. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j. cell.2011.02.013
18. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140:883-99; PMID:20303878; http://dx.doi.org/10.1016/j. cell.2010.01.025
19. Coussens LM, Werb Z. Inflammatory cells and cancer: think different! J Exp Med 2001; 193:F23-6; PMID:11257144; http://dx.doi.org/10.1084/jem.193.6.F23 (Pubitemid 32524459)
20. Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. Andrographolide inhibits oral squamous cell carcinogenesis through NF-kB inactivation. J Dent Res 2011; 90:1246-52; PMID:21841043; http://dx.doi.org/10.1177/0022034511418341
21. Li YD, Ye BQ, Zheng SX, Wang JT, Wang JG, Chen M, Liu JG, Pei XH, Wang LJ, Lin ZX, et al. NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. J Biol Chem 2009; 284:4473-83; PMID:19095643; http://dx.doi.org/10.1074/jbc.M806010200
22. Ziegler-Heitbrock HW, Petersmann I, Frankenberger M. p50 (NF-kappa B1) is upregulated in LPS tolerant P388D1 murine macrophages. Immunobiology 1997; 198:73-80; PMID:9442379; http://dx.doi.org/10.1016/S0171-2985(97)80028-9 (Pubitemid 28021383)
23. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3:133-46; PMID:12563297; http://dx.doi.org/10.1038/nri1001 (Pubitemid 37328691)
24. Bohuslav J, Kravchenko VV, Parry GC, Erlich JH, Gerondakis S, Mackman N, Ulevitch RJ. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J Clin Invest 1998; 102:1645-52; PMID:9802878; http://dx.doi.org/10.1172/JCI3877 (Pubitemid 28516249)
25. Liu J, Beller D. Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter. J Immunol 2002; 169:581-6; PMID:12077291 (Pubitemid 34686182)
26. Kanarek N, Ben-Neriah Y. Regulation of NF-kB by ubiquitination and degradation of the I?Bs. Immunol Rev 2012; 246:77-94; PMID:22435548; http://dx.doi.org/10.1111/j.1600-065X.2012.01098.x
27. Tanaka H, Fujita N, Tsuruo T. 3-Phosphoinositidedependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem 2005; 280:40965-73; PMID:16207722; http://dx.doi.org/10. 1074/jbc. M506235200 (Pubitemid 41780591)
28. Suh SJ, Kwak CH, Chung TW, Park SJ, Cheeeei M, Park SS, Seo CS, Son JK, Chang YC, Park YG, et al. Pimaric acid from Aralia cordata has an inhibitory effect on TNF-a-induced MMP-9 production and HASMC migration via down-regulated NF-kB and AP-1. Chem Biol Interact 2012; 199:112-9; PMID:22705379; http://dx.doi.org/10.1016/j. cbi.2012.06.003
29. Lu Y, Suh SJ, Li X, Liang JL, Chi M, Hwangbo K, Kwon O, Chung TW, Kwak CH, Kwon KM, et al. Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-?B and activator protein-1 activation in mouse bone marrow-derived mast cells. Biol Pharm Bull 2012; 35:938-45; PMID:22687535; http://dx.doi.org/10.1248/bpb.35.938