Bruton's Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response

Cell Reports

Volumn 10, Issue 7, 2015, Pages 1055-1065

  Lee, Koon Guan ^a   Kim, SusanaSoo Yeon ^a   Kui, Lin ^a   Voon, DominicChih Cheng ^b   Mauduit, Marjorie ^c   Bist, Pradeep ^d   Bi, Xuezhi ^a   Pereira, NatashaAnn ^a   Liu, Chengcheng ^a   Sukumaran, Bindu ^d   Rénia, Laurent ^c   Ito, Yoshiaki ^b   Lam, Kong Peng ^a,e  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; BRUTON TYROSINE KINASE; DEAD BOX PROTEIN; DOUBLE STRANDED DNA; HELICASE; INTERFERON; INTERFERON REGULATORY FACTOR 3; PROTEIN DDX41; PROTEIN SH2; PROTEIN SH3; PROTEIN STING; TYROSINE; UNCLASSIFIED DRUG; AGAMMAGLOBULINAEMIA TYROSINE KINASE; DDX41 PROTEIN, MOUSE; DNA; IRF3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; PHOSPHOPEPTIDE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TBK1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AT RICH SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; ANIMAL; BINDING SITE; C57BL MOUSE; CELL LINE; CHEMISTRY; DEFICIENCY; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MOLECULAR DYNAMICS; MORTALITY; PARASITEMIA; PATHOLOGY; SURVIVAL RATE; VETERINARY;

BACTERIA (MICROORGANISMS);

ANIMALS; BINDING SITES; CELL LINE; DEAD-BOX RNA HELICASES; DNA; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR DYNAMICS SIMULATION; PARASITEMIA; PHOSPHOPEPTIDES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 84924617859     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.01.039     Document Type: Article

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