Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

Obesity

Volumn 23, Issue 1, 2015, Pages 120-129

  Cangeri Di Naso, Fábio ^a   Rosa Porto, Rossana ^a,b   Sarubbi Fillmann, Henrique ^a,c   Maggioni, Lucas ^c   Vontobel Padoin, Alexandre ^c   Jacques Ramos, Rafael ^c   Corá Mottin, Claudio ^c   Bittencourt, Aline ^a,b   Anair Possa Marroni, Norma ^a,d   Ivo Homem De Bittencourt, Paulo ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b National Institute of Hormones and Women's Health   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; INSULIN; METFORMIN; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE;

ADULT; ANALYSIS OF VARIANCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BARIATRIC SURGERY; BODY FAT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; STEATOSIS; UNFOLDED PROTEIN RESPONSE; WAIST CIRCUMFERENCE; ADIPOSE TISSUE; CLINICAL TRIAL; COMPLICATION; DOWN REGULATION; INFLAMMATION; INTRAABDOMINAL FAT; LIVER FUNCTION TEST; METABOLISM; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; PATHOLOGY; PHYSIOLOGY;

ADIPOSE TISSUE; ADULT; BARIATRIC SURGERY; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84924605425     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20919     Document Type: Article

References (40)

1. Pi-Sunyer FX,. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002; 10 (Suppl 2): 97S-104S.
2. Vernon G, Baranova A, Younossi ZM,. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-285.
3. Gregor MF, Hotamisligil GS,. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415-445.
4. Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ,. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003; 112: 91-100.
5. Tarantino G,. Should nonalcoholic fatty liver disease be regarded as a hepatic illness only? World J Gastroenterol 2007; 13: 4669-4672.
6. Boden G, Duan X, Homko C, et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008; 57: 2438-2444.
7. Sampey BP, Vanhoose AM, Winfield HM, et al. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity 2011; 19: 1109-1117.
8. Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF,. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 2007; 48: 751-762.
9. Hotamisligil GS,. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005; 54 (Suppl 2): S73-S78.
10. Johnson GL, Nakamura K,. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 2007; 1773: 1341-1348.
11. Chan JY, Ou CC, Wang LL, Chan SH,. Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-kappaB activation and inducible nitric oxide synthase expression in the rostral ventrolateral medulla. Circulation 2004; 110: 3560-3566.
12. Chen HW, Kuo HT, Wang SJ, Lu TS, Yang RC,. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Shock 2005; 24: 232-238.
13. Gabai VL, Meriin AB, Mosser DD, et al. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem 1997; 272: 18033-18037.
14. Gutierrez LL, Maslinkiewicz A, Curi R, Homem, de Bittencourt PI Jr,. Atherosclerosis: a redox-sensitive lipid imbalance suppressible by cyclopentenone prostaglandins. Biochem Pharmacol 2008; 75: 2245-2262.
15. Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 2000; 403: 103-108.
16. Bruce CR, Carey AL, Hawley JA, Febbraio MA,. Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 2003; 52: 2338-2345.
17. Rodrigues-Krause J, Krause M, O'Hagan C, et al. Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? Cell Stress Chaperones 2012; 17: 293-302.
18. Chung J, Nguyen AK, Henstridge DC, et al. HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci USA 2008; 105: 1739-1744.
19. Singh IS, He JR, Calderwood S, Hasday JD,. A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor. J Biol Chem 2002; 277: 4981-4988.
20. Knowlton AA,. NFkappaB, heat shock proteins, HSF-1, and inflammation. Cardiovasc Res 2006; 69: 7-8.
21. Dai R, Frejtag W, He B, Zhang Y, Mivechi NF,. c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. J Biol Chem 2000; 275: 18210-18218.
22. Whitesell L, Lindquist S,. Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets 2009; 13: 469-478.
23. Perlemuter G, Davit-Spraul A, Cosson C, et al. Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease. Liver Int 2005; 25: 946-953.
24. Schattenberg JM, Singh R, Wang Y, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 2006; 43: 163-172.
25. Tarantino G, Caputi A,. JNKs, insulin resistance and inflammation: a possible link between NAFLD and coronary artery disease. World J Gastroenterol 2011; 17: 3785-3794.
26. Di Naso FC, Rodrigues G, Dias AS, Porawski M, Fillmann H, Marroni NP,. Hepatic nitrosative stress in experimental diabetes. J Diabetes Complications 2012; 26: 378-381.
27. Zhang X, Xu A, Chung SK, et al. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes 2011; 60: 486-495.
28. Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010; 9: 667-684.
29. Wang CY, Kim HH, Hiroi Y, et al. Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal 2009; 2: ra11.
30. Abdelmohsen K, Pullmann R Jr, Lal A, et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 2007; 25: 543-557.
31. Kim G, Meriin AB, Gabai VL, et al. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell 2012; 11: 617-627.
32. Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI,. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009; 323: 1063-1066.
33. Raynes R, Pombier KM, Nguyen K, Brunquell J, Mendez JE, Westerheide SD,. The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. PLoS One 2013; 8: e54364.
34. Aravinthan A, Scarpini C, Tachtatzis P, et al. Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease. J Hepatol 2013; 58: 549-556.
35. Wiemann SU, Satyanarayana A, Tsahuridu M, et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 2002; 16: 935-942.
36. Newsholme P, Homem, de Bittencourt PI Jr,. The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease. Curr Opin Clin Nutr Metab Care 2014; 17: 295-305.
37. Maina V, Sutti S, Locatelli I, et al. Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice. Clin Sci 2012; 122: 545-553.
38. Baffy G,. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol 2009; 51: 212-223.
39. Clementi AH, Gaudy AM, van Rooijen N, Pierce RH, Mooney RA,. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 2009; 1792: 1062-1072.
40. Zelber-Sagi S, Lotan R, Shlomai A, et al. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. J Hepatol 2012; 56: 1145-1151.