Association of IL-6 polymorphism -174G/C and metabolic syndrome in hypertensive patients

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Teixeira, Andrei Alkmim ^a   Quinto, Beata Marie Redublo ^a   Dalboni, Maria Aparecida ^a,b   Rodrigues, Cassio Jose De Oliveira ^a   Batista, Marcelo Costa ^a,c,d  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Nove de Julho University   (Brazil)

^c TUFTS UNIVERSITY   (United States)

^d HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HYPERTENSION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PREVALENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; AGED; ALLELE; COMPLICATION; DIABETES MELLITUS; GENETIC PREDISPOSITION; GENETICS; PATHOLOGY;

AGED; ALLELES; DIABETES MELLITUS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; INTERLEUKIN-6; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84924598045     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/927589     Document Type: Article

References (80)

1. H.-M. Lakka, D. E. Laaksonen, T. A. Lakka et al., "The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men," The Journal of the American Medical Association, Vol. 288, no. 21, pp. 2709-2716, 2002.
2. P. Lempiainen, L. Mykkanen, K. Pyorala, M. Laakso, and J. Kuusisto, "Insulin resistance syndrome predicts coronary heart disease events in elderly non-diabetic men," Circulation, Vol. 100, pp. 123-128, 1999.
3. J. Kuusisto, P. Lempiainen, L. Mykkanen, and M. Laakso, "Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men," Diabetes Care, Vol. 24, no. 9, pp. 1629-1633, 2001.
4. A. Onat, K. Ceyhan, Ö. Bąsar, B. Erer, S. Toprak, and V. Sansoy, "Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels-a prospective and cross-sectional evaluation," Atherosclerosis, Vol. 165, no. 2, pp. 285-292, 2002.
5. C. M. Alexander, P. B. Landsman, S. M. Teutsch, and S. M. Haffner, "NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older," Diabetes, Vol. 52, no. 5, pp. 1210-1214, 2003.
6. P. T. Katzmarzyk, T. S. Church, and S. N. Blair, "Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men," Archives of Internal Medicine, Vol. 164, no. 10, pp. 1092-1097, 2004.
7. E. S. Ford, "The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study," Atherosclerosis, Vol. 173, no. 2, pp. 309-314, 2004.
8. C. J. Girman, T. Rhodes, M. Mercury et al., "The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)," The American Journal of Cardiology, Vol. 93, no. 2, pp. 136-141, 2004.
9. S. Malik, N. D. Wong, S. S. Franklin et al., "Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults," Circulation, Vol. 110, no. 10, pp. 1245-1250, 2004.
10. K. J. Hunt, R. G. Resendez, K. Williams, S. M. Haffner, and M. P. Stern, "National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Hearth Study," Circulation, Vol. 110, no. 10, pp. 1251-1257, 2004.
11. K. M. Rexrode, A. Pradhan, J. E. Manson, J. E. Buring, and P. M. Ridker, "Relationship of total and abdominal adiposity with CRP and IL-6 in women," Annals of Epidemiology, Vol. 13, no. 10, pp. 674-682, 2003.
12. A. De Lorenzo, V. Del Gobbo, M. G. Premrov, M. Bigioni, F. Galvano, and L. Di Renzo, "Normalweight obese syndrome: early inflammation?" American Journal of Clinical Nutrition, Vol. 85, no. 1, pp. 40-45, 2007.
13. J. S. Yudkin, M. Kumari, S. E. Humphries, and V. Mohamed-Ali, "inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?" Atherosclerosis, Vol. 148, no. 2, pp. 209-214, 2000.
14. B. Vozarova, C. Weyer, K. Hanson, P. A. Tataranni, C. Bogardus, and R. E. Pratley, "Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion," Obesity Research, Vol. 9, no. 7, pp. 414-417, 2001.
15. D. Fishman, G. Faulds, R. Jeffey et al., "The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis," The Journal of Clinical Investigation, Vol. 102, no. 7, pp. 1369-1376, 1998.
16. K. K. Berg, H. O. Madsen, P. Garred, R. Wiseth, S. Gunnes, and V. Videm, "The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease," Scandinavian Journal of Immunology, Vol. 69, no. 1, pp. 36-42, 2009.
17. M. Revilla, V. Obach, Á. Cervera, A. Dávalos, J. Castillo, and Á. Chamorro, "A-174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction," Neuroscience Letters, Vol. 324, no. 1, pp. 29-32, 2002.
18. A. Losito, K. Kalidas, S. Santoni, and S. Jeffery, "Association of interleukin-6-174G/C promoter polymorphism with hypertension and left ventricular hypertrophy in dialysis patients," Kidney International, Vol. 64, no. 2, pp. 616-622, 2003.
19. O. P. Kristiansen and T. Mandrup-Poulsen, "Interleukin-6 and diabetes: the good, the bad, or the indifferent?" Diabetes, Vol. 54, supplement 2, pp. S114-S124, 2005.
20. B. Pyrzak, A. Wisniewska, A. Majcher, K. Popko, M. Wasik, and U. Demkow, "Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children," European Journal of Medical Research, Vol. 14, no. 4, pp. 196-200, 2009.
21. A. Moleres, T. Rendo-Urteaga, C. Azcona et al., "IL6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors," Journal of Physiology and Biochemistry, Vol. 65, no. 4, pp. 405-413, 2009.
22. IDF, The IDF Consensus Worldwide Definition of the Metabolic Syndrome, International Diabetes Federation, 2006.
23. M. J. Pencina, R. B. D'Agostino, M. G. Larson, J. M. Massaro, and R. S. Vasan, "Predicting the 30-year risk of cardiovascular disease: the framingham heart study," Circulation, Vol. 119, no. 24, pp. 3078-3084, 2009.
24. P. Greenland, J. S. Alpert, G. A. Beller et al., "2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the american college of cardiology foundation/american heart association task force on practice guidelines," Circulation, Vol. 122, no. 25, pp. e584-e636, 2010.
25. D. Perloff, C. Grim, J. Flack et al., "Human blood pressure determination by sphygmomanometry," Circulation, Vol. 88, no. 5, pp. 2460-2470, 1993.
26. L. A. Stevens and N. Stoycheff, "Standardization of serum creatinine and estimated GFR in the Kidney Early Evaluation Program," The American Journal of Kidney Diseases, Vol. 51, supplement 2, no. 4, pp. S77-S82, 2008.
27. K. N. Frayn, "Obesity and metabolic disease: is adipose tissue the culprit?" Proceedings of the Nutrition Society, Vol. 64, no. 1, pp. 7-13, 2005.
28. A. Love and D. Oldford, "Metabolic syndrome," Canadian Journal of Cardiovascular Nursing, Vol. 15, pp. 6-8, 2005.
29. T. M. Ahonen, J. T. Saltevo, H. J. Kautiainen, E. A. Kumpusalo, and M. J. Vanhala, "The association of adiponectin and low-grade inflammation with the course of metabolic syndrome," Nutrition, Metabolism and Cardiovascular Diseases, Vol. 22, no. 3, pp. 285-291, 2012.
30. B. Vozarova, J.-M. Fernández-Real, W. C. Knowler et al., "The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians," Human Genetics, Vol. 112, no. 4, pp. 409-413, 2003.
31. S. E. Humphries, L. A. Luong, M. S. Ogg, E. Hawe, and G. J. Miller, "The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men," European Heart Journal, Vol. 22, no. 24, pp. 2243-2252, 2001.
32. J. Bamoulid, C. Courivaud, M. Deschamps et al., "The inter-leukin-6 gene promoter polymorphism -174 and atherosclerotic events in overweight transplanted patients," Journal of Transplantation, Vol. 2011, Article ID 803429, 6 pages, 2011.
33. L. Qi, R.M.van Dam, J. B. Meigs, J.E. Manson, D. Hunter, and F. B. Hu, "Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis," Human Molecular Genetics, Vol. 15, no. 11, pp. 1914-1920, 2006.
34. K. Esposito and D. Giugliano, "The metabolic syndrome and inflammation: association or causation?" Nutrition, Metabolism and Cardiovascular Diseases, Vol. 14, no. 5, pp. 228-232, 2004.
35. G. Fantuzzi, "Adipose tissue, adipokines, and inflammation," The Journal of Allergy and Clinical Immunology, Vol. 115, no. 5, pp. 911-919, 2005.
36. L. di Renzo, A. Bertoli, M. Bigioni et al., "Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome," Current Pharmaceutical Design, Vol. 14, no. 26, pp. 2699-2706, 2008.
37. I. Wernstedt, A.-L. Eriksson, A. Berndtsson et al., "A common polymorphism in the interleukin-6 gene promoter is associated with overweight," International Journal of Obesity, Vol. 28, no. 10, pp. 1272-1279, 2004.
38. J. W. Stephens, S. J. Hurel, J. A. Cooper, J. Acharya, G. J. Miller, and S. E. Humphries, "A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus," Molecular Genetics and Metabolism, Vol. 82, no. 2, pp. 180-186, 2004.
39. A. Herbert, C. Liu, S. Karamohamed et al., "BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham study," Obesity, Vol. 14, no. 8, pp. 1454-1461, 2006.
40. L. Carulli, I. Canedi, S. Rondinella et al., "Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepati-tis," Digestive and Liver Disease, Vol. 41, no. 11, pp. 823-828, 2009.
41. H.-M. Lakka, D. E. Laaksonen, T. A. Lakka et al., "The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men," The Journal of the American Medical Association, Vol. 288, no. 21, pp. 2709-2716, 2002.
42. P. Lempiainen, L. Mykkanen, K. Pyorala, M. Laakso, and J. Kuusisto, "Insulin resistance syndrome predicts coronary heart disease events in elderly non-diabetic men," Circulation, Vol. 100, pp. 123-128, 1999.
43. J. Kuusisto, P. Lempiainen, L. Mykkanen, and M. Laakso, "Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men," Diabetes Care, Vol. 24, no. 9, pp. 1629-1633, 2001.
44. A. Onat, K. Ceyhan, Ö. Bąsar, B. Erer, S. Toprak, and V. Sansoy, "Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels-a prospective and cross-sectional evaluation," Atherosclerosis, Vol. 165, no. 2, pp. 285-292, 2002.
45. C. M. Alexander, P. B. Landsman, S. M. Teutsch, and S. M. Haffner, "NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older," Diabetes, Vol. 52, no. 5, pp. 1210-1214, 2003.
46. P. T. Katzmarzyk, T. S. Church, and S. N. Blair, "Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men," Archives of Internal Medicine, Vol. 164, no. 10, pp. 1092-1097, 2004.
47. E. S. Ford, "The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study," Atherosclerosis, Vol. 173, no. 2, pp. 309-314, 2004.
48. C. J. Girman, T. Rhodes, M. Mercury et al., "The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)," The American Journal of Cardiology, Vol. 93, no. 2, pp. 136-141, 2004.
49. S. Malik, N. D. Wong, S. S. Franklin et al., "Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults," Circulation, Vol. 110, no. 10, pp. 1245-1250, 2004.
50. K. J. Hunt, R. G. Resendez, K. Williams, S. M. Haffner, and M. P. Stern, "National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Hearth Study," Circulation, Vol. 110, no. 10, pp. 1251-1257, 2004.
51. K. M. Rexrode, A. Pradhan, J. E. Manson, J. E. Buring, and P. M. Ridker, "Relationship of total and abdominal adiposity with CRP and IL-6 in women," Annals of Epidemiology, Vol. 13, no. 10, pp. 674-682, 2003.
52. A. De Lorenzo, V. Del Gobbo, M. G. Premrov, M. Bigioni, F. Galvano, and L. Di Renzo, "Normalweight obese syndrome: early inflammation?" American Journal of Clinical Nutrition, Vol. 85, no. 1, pp. 40-45, 2007.
53. J. S. Yudkin, M. Kumari, S. E. Humphries, and V. Mohamed-Ali, "inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?" Atherosclerosis, Vol. 148, no. 2, pp. 209-214, 2000.
54. B. Vozarova, C. Weyer, K. Hanson, P. A. Tataranni, C. Bogardus, and R. E. Pratley, "Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion," Obesity Research, Vol. 9, no. 7, pp. 414-417, 2001.
55. D. Fishman, G. Faulds, R. Jeffey et al., "The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis," The Journal of Clinical Investigation, Vol. 102, no. 7, pp. 1369-1376, 1998.
56. K. K. Berg, H. O. Madsen, P. Garred, R. Wiseth, S. Gunnes, and V. Videm, "The additive contribution from inflammatory genetic markers on the severity of cardiovascular disease," Scandinavian Journal of Immunology, Vol. 69, no. 1, pp. 36-42, 2009.
57. M. Revilla, V. Obach, Á. Cervera, A. Dávalos, J. Castillo, and Á. Chamorro, "A-174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction," Neuroscience Letters, Vol. 324, no. 1, pp. 29-32, 2002.
58. A. Losito, K. Kalidas, S. Santoni, and S. Jeffery, "Association of interleukin-6-174G/C promoter polymorphism with hypertension and left ventricular hypertrophy in dialysis patients," Kidney International, Vol. 64, no. 2, pp. 616-622, 2003.
59. O. P. Kristiansen and T. Mandrup-Poulsen, "Interleukin-6 and diabetes: the good, the bad, or the indifferent?" Diabetes, Vol. 54, supplement 2, pp. S114-S124, 2005.
60. B. Pyrzak, A. Wisniewska, A. Majcher, K. Popko, M. Wasik, and U. Demkow, "Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children," European Journal of Medical Research, Vol. 14, no. 4, pp. 196-200, 2009.
61. A. Moleres, T. Rendo-Urteaga, C. Azcona et al., "IL6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors," Journal of Physiology and Biochemistry, Vol. 65, no. 4, pp. 405-413, 2009.
62. IDF, The IDF Consensus Worldwide Definition of the Metabolic Syndrome, International Diabetes Federation, 2006.
63. M. J. Pencina, R. B. D'Agostino, M. G. Larson, J. M. Massaro, and R. S. Vasan, "Predicting the 30-year risk of cardiovascular disease: the framingham heart study," Circulation, Vol. 119, no. 24, pp. 3078-3084, 2009.
64. P. Greenland, J. S. Alpert, G. A. Beller et al., "2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the american college of cardiology foundation/american heart association task force on practice guidelines," Circulation, Vol. 122, no. 25, pp. e584-e636, 2010.
65. D. Perloff, C. Grim, J. Flack et al., "Human blood pressure determination by sphygmomanometry," Circulation, Vol. 88, no. 5, pp. 2460-2470, 1993.
66. L. A. Stevens and N. Stoycheff, "Standardization of serum creatinine and estimated GFR in the Kidney Early Evaluation Program," The American Journal of Kidney Diseases, Vol. 51, supplement 2, no. 4, pp. S77-S82, 2008.
67. K. N. Frayn, "Obesity and metabolic disease: is adipose tissue the culprit?" Proceedings of the Nutrition Society, Vol. 64, no. 1, pp. 7-13, 2005.
68. A. Love and D. Oldford, "Metabolic syndrome," Canadian Journal of Cardiovascular Nursing, Vol. 15, pp. 6-8, 2005.
69. T. M. Ahonen, J. T. Saltevo, H. J. Kautiainen, E. A. Kumpusalo, and M. J. Vanhala, "The association of adiponectin and low-grade inflammation with the course of metabolic syndrome," Nutrition, Metabolism and Cardiovascular Diseases, Vol. 22, no. 3, pp. 285-291, 2012.
70. B. Vozarova, J.-M. Fernández-Real, W. C. Knowler et al., "The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians," Human Genetics, Vol. 112, no. 4, pp. 409-413, 2003.
71. S. E. Humphries, L. A. Luong, M. S. Ogg, E. Hawe, and G. J. Miller, "The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men," European Heart Journal, Vol. 22, no. 24, pp. 2243-2252, 2001.
72. J. Bamoulid, C. Courivaud, M. Deschamps et al., "The inter-leukin-6 gene promoter polymorphism -174 and atherosclerotic events in overweight transplanted patients," Journal of Transplantation, Vol. 2011, Article ID 803429, 6 pages, 2011.
73. L. Qi, R.M.van Dam, J. B. Meigs, J.E. Manson, D. Hunter, and F. B. Hu, "Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis," Human Molecular Genetics, Vol. 15, no. 11, pp. 1914-1920, 2006.
74. K. Esposito and D. Giugliano, "The metabolic syndrome and inflammation: association or causation?" Nutrition, Metabolism and Cardiovascular Diseases, Vol. 14, no. 5, pp. 228-232, 2004.
75. G. Fantuzzi, "Adipose tissue, adipokines, and inflammation," The Journal of Allergy and Clinical Immunology, Vol. 115, no. 5, pp. 911-919, 2005.
76. L. di Renzo, A. Bertoli, M. Bigioni et al., "Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome," Current Pharmaceutical Design, Vol. 14, no. 26, pp. 2699-2706, 2008.
77. I. Wernstedt, A.-L. Eriksson, A. Berndtsson et al., "A common polymorphism in the interleukin-6 gene promoter is associated with overweight," International Journal of Obesity, Vol. 28, no. 10, pp. 1272-1279, 2004.
78. J. W. Stephens, S. J. Hurel, J. A. Cooper, J. Acharya, G. J. Miller, and S. E. Humphries, "A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus," Molecular Genetics and Metabolism, Vol. 82, no. 2, pp. 180-186, 2004.
79. A. Herbert, C. Liu, S. Karamohamed et al., "BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham study," Obesity, Vol. 14, no. 8, pp. 1454-1461, 2006.
80. L. Carulli, I. Canedi, S. Rondinella et al., "Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepati-tis," Digestive and Liver Disease, Vol. 41, no. 11, pp. 823-828, 2009.