Genetic polymorphisms in non-alcoholic fatty liver disease: Interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis

Digestive and Liver Disease

Volumn 41, Issue 11, 2009, Pages 823-828

  Carulli, L ^a   Canedi, I ^a   Rondinella, S ^a   Lombardini, S ^a   Ganazzi, D ^a   Fargion, S ^b   De Palma, M ^c   Lonardo, A ^a   Ricchi, M ^a   Bertolotti, M ^a   Carulli, N ^a   Loria, P ^a  

^a Dipartimento di Emergenza e Urgenza   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Genes; IL 6; Inflammation; Insulin resistance; Steatohepatitis; Steatosis

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

CASE-CONTROL STUDIES; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 70349898246     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2009.03.005     Document Type: Article

References (44)

1. Sanyal A.J. American Gastroenterological Association. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 123 (2002) 1705-1725
2. Neuschwander-Tetri B.A., and Caldwell S.H. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37 (2003) 1202-1219
3. McCullough A.J. The clinical features, diagnosis and natural history of nonalcoholic fattyliver disease. Clin Liver Dis 8 (2004) 521-533
4. Bugianesi E., McCullough A.J., and Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42 (2005) 987-1000
5. Loria P., Lonardo A., and Carulli N. Should nonalcoholic fatty liver disease be renamed?. Dig Dis 23 (2005) 72-82
6. Trombetta M., Spiazzi G., Zoppini G., and Muggeo M. Review article: type 2 diabetes and chronic liver disease in the Verona diabetes study. Aliment Pharmacol Ther 22 Suppl. 2 (2005) 24-27
7. Clark J.M., Brancati F.L., and Diehl A.M. Nonalcoholic fatty liver disease. Gastroenterology 122 (2002) 1649-1657
8. Liangpunsakul S., and Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 329 (2005) 111-116
9. Wilfred de Alwis N.M., and Day C.P. Genes and nonalcoholic fatty liver disease. Curr Diab Rep 8 (2008) 156-163
10. Younossi Z.M., Baranova A., Ziegler K., Del Giacco L., Schlauch K., Born T.L., et al. A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease. Hepatology 42 (2005) 665-674
11. Maddux B.A., Sbraccia P., Kumakura S., Sasson S., Youngren J., Fisher A., et al. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 373 (1995) 448-451
12. Costanzo B.V., Trischitta V., Di Paola R., Spampinato D., Pizzuti A., Vigneri R., et al. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 50 (2001) 831-836
13. Abate N., Carulli L., Cabo-Chan Jr. A., Chandalia M., Snell P.G., and Grundy S.M. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. J Clin Endocrinol Metab 88 (2003) 5927-5934
14. Frittitta L., Baratta R., Spampanato D., Di Paola R., Pizzuti A., Vigneri R., et al. The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. J Clin Endocrinol Metabolism 86 (2001) 5888-5891
15. Tarugi P., Lonardo A., Ballarini G., Grisendi A., Pulvirenti M., Bagni A., et al. Fatty liver in heterozygous hypobetalipoproteinemia caused by a novel truncated form of apolipoprotein B. Gastroenterology 111 (1996) 1125-1133
16. Namikawa C., Shu-Ping Z., Vyselaar J.R., Nozaki Y., Nemoto Y., Ono M., et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J Hepatol 40 (2004) 781-786
17. Zampino R., Ingrosso D., Durante-Mangoni E., Capasso R., Tripodi M.F., Restivo L., et al. Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients. J Viral Hepat 15 (2008) 740-746
18. Fernandez Real J.M., Broch M., Vendrell J., Gutierrez C., Casamitjana R., Pugeat M., et al. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 49 (2000) 517-520
19. Kubaszek A., Pihlajamäki J., Punnonen K., Karhapää P., Vauhkonen Ilkka, and Laakso M. The C-174G promoter polymorphism of the IL6 gene affects energy expenditure and insulin sensitivity. Diabetes 52 (2003) 558-561
20. Chang Y.H., Huang C.N., and Shiau M.Y. The C-174G promoter polymorphism of the interleukin-6 (IL-6) gene that affects insulin sensitivity in Caucasians is not involved in the pathogenesis of Taiwanese type 2 diabetes mellitus. Eur Cytokine Netw 15 (2004) 117-119
21. Lonardo A., Loria P., Leonardi F., Borsatti A., Neri P., Pulvirenti M., et al. Policentrica Steatosi Epatica Non Alcolica. Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study. Dig Liver Dis 34 (2002) 204-211
22. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
23. Expert committee on the diagnosis and classification of Diabetes Mellitus. American Diabetes Association: Clinical Practice Recommendations 2002. Diab Care 2002;Suppl 1:S1-S147.
24. Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 106 (2002) 3143-3421
25. Brunt E.M. Nonalcoholic steatohepatitis. Semin Liver Dis 24 (2004) 3-20
26. Dandona P., Aljada A., Chaudhuri A., Mohanty P., and Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111 (2005) 1448-1454
27. Berthier M.T., Paradis A.M., Tchernof A., Bergeron J., Prud'homme D., Després J.D., et al. The interleukin-6-174 G/C polymorphism is associated with indices of obesity in men. Hum Genet 48 (2003) 14-19
28. Wernstedt I., Eriksson A.L., Berndtsson A., Hoffstedt J., Skrtic S., Hedner T., et al. A common polymorphism in the interleukin-6 gene promoter is associated with overweight. Int J Obes Relat Metab Disord 28 (2004) 1272-1279
29. Humphries S.E., Luong L.A., Ogg M.S., Hawe E., and Miller G.J. The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22 (2001) 2243-2252
30. Kubaszek A., Pihlajamaki J., Komarovski V., Lindi V., Lindstrom J., Eriksson J., et al. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 52 (2003) 1872-1876
31. Fishman D., Faulds G., Jeffery R., Mohamed Alì V., Yudkin J.S., Humphries S., et al. The effects of novel polymorphism in the interleukin 6 gene on IL-6 trancription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 (1998) 1369-1376
32. Fernandez-Real J.M., Broch M., Vendrell J., Richart C., and Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 85 (2000) 1335-1339
33. Hamid Y.H., Rose C.S., Urhammer S.A., Glümer C., Nolsøe R., Kristiansen O.P., et al. Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 48 (2005) 251-260
34. Vozarova B., Fernandez-Real J.M., Knowler W.C., Gallart L., Hanson R.L., Gruber J.D., et al. The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasian. Hum Genet 112 (2003) 409-413
35. Cardellini M., Perego L., D'Adamo M., Marini M.A., Procopio C., Hribal M.L., et al. C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diab Care 28 (2005) 2007-2012
36. Illig T., Bongardt F., Schopfer A., Muller-Scholze S., Rathmann W., Koenig W., et al. Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. J Clin Endocrinol Metab 89 (2004) 5053-5058
37. Gleeson D., Bradley M.P., Jones J., Peck R.J., Bond S.K., Teare M.D., and Duff G.W. Cytokine gene polymorphisms in heavy drinkers with and without decompensated liver disease: a case-control study. Am J Gastroenterol 103 (2008) 3039-3046
38. Abate N., Chandalia M., Satija P., Adams-Huet B., Grundy S.M., Sandeep S., Radha V., et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 54 (2005) 1207-1213
39. Hamaguchi K., Terao H., Kusuda Y., Yamashita T., Hazoury Bahles J.A., Cruz L.L.M., et al. The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. J Clin Endocrinol Metab 89 (2004) 1359-1364
40. Morrison J.A., Gruppo R., Glueck C.J., Stroop D., Fontaine R.N., Wang P., et al. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene is strongly associated with race but not with insulin resistance in black and white children. Metabolism 53 (2004) 465-468
41. Rasmussen S.K., Urhammer S.A., Pizzuti A., Echwald S.M., Ekstrom C.T., Hansen L., et al. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. Diabetes 49 (2000) 1608-1611
42. Gonzalez-Sanchez J.L., Martinez-Larrad M.T., Fernandez-Perez C., Kubaszek A., Laakso M., and Serrano-Rios M. K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population. Obes Res 11 (2003) 603-605
43. Lonardo A., Lombardini S., Scaglioni F., Carulli L., Ricchi M., Ganazzi D., et al. Hepatic steatosis and insulin resistance: does etiology make a difference?. J Hepatol 44 (2006) 190-196
44. Enkhmaa B., Shiwaku K., Anuurad E., Nogi A., Kitajima K., Yamasaki M., et al. Prevalence of the metabolic syndrome using the Third Report of the National et al. Cholesterol Educational Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III) and the modified ATP III definitions for Japanese and Mongolians. Clin Chim Acta 352 (2005) 105-113