α-synuclein is prone to interaction with the GC-box-like sequence in vitro

Cellular and Molecular Neurobiology

Volumn 34, Issue 4, 2014, Pages 603-609

  Ma, Kai Li ^a,b   Song, Lian Kun ^a   Yuan, Yu He ^a   Zhang, Ying ^b   Yang, Jin Ling ^a   Zhu, Ping ^a   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b INSTITUTE OF MEDICAL BIOLOGY   (China)

Author keywords

Circular dichroism; DNA; GC box like sequence; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; DNA; DNA BINDING PROTEIN; NERVE PROTEIN;

GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; LEWY BODY; METABOLISM; NERVE CELL; PHYSIOLOGY; PICHIA;

ALPHA-SYNUCLEIN; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; LEWY BODIES; NERVE TISSUE PROTEINS; NEURONS; PICHIA;

EID: 84898884129     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-014-0046-9     Document Type: Article

References (34)

1. Ahn BW, Song DU, Jung YD, Chay KO, Chung MA, Yang SY, Shin BA (2000) Detection of beta-amyloid peptide aggregation using DNA electrophoresis. Anal Biochem 284(2):401-405
2. Basham B, Schroth GP, Ho PS (1995) An A-DNA triplet code: thermodynamic rules for predicting A- and B-DNA. Proc Natl Acad Sci USA 92(14):6464-6468
3. Boyer F, Dreyer JL (2007) Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. Eur J Neurosci 26(10):2764-2776
4. Cary PD, Kneale GG (2009) Circular dichroism for the analysis of protein-DNA interactions. Methods Mol Biol 543:613-624
5. Cherny D, Hoyer W, Subramaniam V, Jovin TM (2004) Double-stranded DNA stimulates the fibrillation of alpha-synuclein in vitro and is associated with the mature fibrils: an electron microscopy study. J Mol Biol 344(4):929-938
6. Compton LA, Johnson WC Jr (1986) Analysis of protein circular dichroism spectra for secondary structure using a simple matrix multiplication. Anal Biochem 155(1):155-167
7. Cordeiro Y, Machado F, Juliano L, Juliano MA, Brentani RR, Foguel D, Silva JL (2001) DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation. J Biol Chem 276(52):49400-49409
8. Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302(5646):819-822
9. Gabus C, Derrington E, Leblanc P, Chnaiderman J, Dormont D, Swietnicki W, Morillas M, Surewicz WK, Marc D, Nandi P, Darlix JL (2001) The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1. J Biol Chem 276(22):19301-19309
10. Goedert M (2001) Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2(7):492-501
11. Goers J, Manning-Bog AB, McCormack AL, Millett IS, Doniach S, Di Monte DA, Uversky VN, Fink AL (2003) Nuclear localization of alpha-synuclein and its interaction with histones. Biochemistry 42(28):8465-8471
12. Gray DM, Hung SH, Johnson KH (1995) Absorption and circular dichroism spectroscopy of nucleic acid duplexes and triplexes. Methods Enzymol 246:19-34
13. Hardin CC, Henderson E, Watson T, Prosser JK (1991) Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. Biochemistry 30(18):4460-4472
14. Hegde ML, Vasudevaraju P, Rao KJ (2010) DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease. Front Biosci 15:418-436
15. Johnson WC Jr (1990) Protein secondary structure and circular dichroism: a practical guide. Proteins 7(3):205-214
16. Johnson BB, Dahl KS, Tinoco I Jr, Ivanov VI, Zhurkin VB (1981) Correlations between deoxyribonucleic acid structural parameters and calculated circular dichroism spectra. Biochemistry 20(1):73-78
17. Kampers T, Friedhoff P, Biernat J, Mandelkow EM, Mandelkow E (1996) RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. FEBS Lett 399(3):344-349
18. Kontopoulos E, Parvin JD, Feany MB (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15(20):3012-3023
19. Lee VM, Trojanowski JQ (2006) Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron 52(1):33-38
20. Lees JG, Miles AJ, Wien F, Wallace BA (2006) A reference database for circular dichroism spectroscopy covering fold and secondary structure space. Bioinformatics 22(16):1955-1962
21. Ma KL, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH (2013) The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle. Neuropharmacology. doi: 10.1016/j.neuropharm.2013.07.035
22. Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8(8):2804-2815
23. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287(5456):1265-1269
24. McLean PJ, Ribich S, Hyman BT (2000) Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations. J Neural Transm Suppl 58:53-63
25. Nandi PK (1998) Polymerization of human prion peptide HuPrP 106-126 to amyloid in nucleic acid solution. Arch Virol 143(7):1251-1263
26. Nandi PK, Leclerc E, Nicole JC, Takahashi M (2002) DNA-induced partial unfolding of prion protein leads to its polymerisation to amyloid. J Mol Biol 322(1):153-161
27. Padmaraju V, Bhaskar JJ, Prasada Rao UJ, Salimath PV, Rao KS (2011) Role of advanced glycation on aggregation and DNA binding properties of alpha-synuclein. J Alzheimers Dis 24(Suppl 2):211-221
28. Recchia A, Debetto P, Negro A, Guidolin D, Skaper SD, Giusti P (2004) Alpha-synuclein and Parkinson's disease. Faseb J 18(6):617-626
29. Rich A (1993) DNA comes in many forms. Gene 135(1-2):99-109
30. Scarlett GP, Elgar SJ, Cary PD, Noble AM, Orford RL, Kneale GG, Guille MJ (2004) Intact RNA-binding domains are necessary for structure-specific DNA binding and transcription control by CBTF122 during Xenopus development. J Biol Chem 279(50):52447-52455
31. Specht CG, Tigaret CM, Rast GF, Thalhammer A, Rudhard Y, Schoepfer R (2005) Subcellular localisation of recombinant alpha- and gamma-synuclein. Mol Cell Neurosci 28(2):326-334
32. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839-840
33. Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T (2003) Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila. Neurosci Lett 336(3):155-158
34. von Bohlen Und Halbach O (2004) Synucleins and their relationship to Parkinson's disease. Cell Tissue Res 318(1):163-174