Amyloid β oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes

Gene

Volumn 561, Issue 1, 2015, Pages 76-81

  Zhang, Qinghua ^a   Guo, Shougang ^a   Zhang, Xiao ^a   Tang, Shi ^a   Wang, Lu ^a   Han, Xiaojuan ^a   Shao, Wen ^a   Cong, Lin ^a   Du, Yifeng ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Amyloid 1 42 oligomers; Astrocyte; ERK1 2; Insulin receptor substrate 1; Insulin signaling

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLOID BETA OLIGOMER; AMYLOID BETA PROTEIN[1-42]; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OLIGOMER; PHOSPHATIDYLINOSITOL 3 KINASE; SERINE; TYROSINE; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); FLAVONOID; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN RECEPTOR SUBSTRATE; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT; PROTEIN BINDING;

ARTICLE; ASTROCYTE; CELL CULTURE; CELL LYSATE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPE; FLUORESCENCE MICROSCOPY; GLYCOGEN ANALYSIS; GLYCOGEN STORAGE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NORMAL HUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STORAGE; WESTERN BLOTTING; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

AMYLOID BETA-PEPTIDES; ASTROCYTES; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84924541882     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2015.02.011     Document Type: Article

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