L-cysteine suppresses ghrelin and reduces appetite in rodents and humans

International Journal of Obesity

Volumn 39, Issue 3, 2015, Pages 447-455

  Mcgavigan, A K ^a   O'hara, H C ^a   Amin, A ^a   Kinsey Jones, J ^a   Spreckley, E ^a   Alamshah, A ^a   Agahi, A ^a   Banks, K ^a   France, R ^a   Hyberg, G ^a   Wong, C ^a   Bewick, G A ^a,c   Gardiner, J V ^a   Lehmann, A ^b,d   Martin, N M ^a   Ghatei, M A ^a   Bloom, S R ^a   Murphy, K G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NextRx   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; GASTROINTESTINAL HORMONE; GHRELIN; GLYCINE; ANOREXIGENIC AGENT; HORMONE RECEPTOR; MESSENGER RNA; NEUROPEPTIDE RECEPTOR;

ADULT; ANIMAL EXPERIMENT; APPETITE; AREA POSTREMA; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DRUG EFFECT; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HUNGER; HYPOTHALAMUS; MALE; MOUSE; NERVE CELL; NONHUMAN; NORMAL HUMAN; OBESITY; PLASMA; PRIORITY JOURNAL; RAT; RODENT; SCORING SYSTEM; STOMACH EMPTYING; TASTE AVERSION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; EATING; METABOLISM; SATIETY; WISTAR RAT;

MUS; RATTUS; RODENTIA;

ADULT; ANIMALS; APPETITE; APPETITE DEPRESSANTS; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; GASTROINTESTINAL HORMONES; GHRELIN; HUMANS; HYPOTHALAMUS; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, WISTAR; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; SATIATION;

EID: 84924527917     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.172     Document Type: Article

References (39)

1. Westerterp-Plantenga MS, Lejeune MP, Nijs I, van Ooijen M, Kovacs EM. High protein intake sustains weight maintenance after body weight loss in humans. Int J Obes Relat Metab Disord 2004; 28: 57-64
2. Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 2005; 82: 41-48
3. Fromentin G, Darcel N, Chaumontet C, Marsset-Baglieri A, Nadkarni N, Tome D. Peripheral and central mechanisms involved in the control of food intake by dietary amino acids and proteins. Nutr Res Rev 2012; 25: 29-39
4. Koehnle TJ, Russell MC, Gietzen DW. Rats rapidly reject diets deficient in essential amino acids. J Nutr 2003; 133: 2331-2335
5. Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr 2003; 89: 239-248
6. Hochstenbach-Waelen A, Westerterp-Plantenga MS, Veldhorst MA, Westerterp KR. Single-protein casein and gelatin diets affect energy expenditure similarly but substrate balance and appetite differently in adults. J Nutr 2009; 139: 2285-2292
7. Abou-Samra R, Keersmaekers L, Brienza D, Mukherjee R, Mace K. Effect of different protein sources on satiation and short-Term satiety when consumed as a starter. Nutr J 2011; 10: 139
8. Solah VA, Kerr DA, Adikara CD, Meng X, Binns CW, Zhu K, et al. Differences in satiety effects of alginate-And whey protein-based foods. Appetite 2010; 54: 485-491
9. Wellendorph P, Johansen LD, Brauner-Osborne H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular pharmacology 2009; 76: 453-465
10. Blouet C, Jo YH, Li X, Schwartz GJ. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci 2009; 29: 8302-8311
11. Blouet C, Schwartz GJ. Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding. Cell Metab 2012; 16: 579-587
12. Freudenberg A, Petzke KJ, Klaus S. Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice. J Nutr Biochem 2012; 23: 1524-1530
13. Bewick GA, Kent A, Campbell D, Patterson M, Ghatei MA, Bloom SR, et al. Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity. Diabetes 2009; 58: 840-846
14. Lachey JL, D'Alessio DA, Rinaman L, Elmquist JK, Drucker DJ, Seeley RJ. The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2005; 146: 458-462
15. Semjonous NM, Smith KL, Parkinson JR, Gunner DJ, Liu YL, Murphy KG, et al. Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance. Int J Obes (Lond) 2009; 33: 775-785
16. Parsons RB, Waring RH, Ramsden DB, Williams AC. In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines. Neurotoxicology 1998; 19: 599-603
17. McGowan BM, Stanley SA, White NE, Spangeus A, Patterson M, Thompson EL, et al. Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats. Am J Physiol Endocrinol Metab 2007; 292: E913-E919
18. Paxinos G, Watson C. The rat brain in stereotaxic co-ordinates, 6th edn. Academic Press, 2007; p 456
19. Wang L, Murphy NP, Stengel A, Goebel-Stengel M St, Pierre DH, Maidment NT, et al. Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats. Neurogastroenterol Motil 2012; 24: e235-e245
20. Gondim FA, Oliveira GR, Graca JR, Gondim RB, Alencar HM, Dantas RP, et al. Neural mechanisms involved in the delay of gastric emptying of liquid elicited by acute blood volume expansion in awake rats. Neurogastroenterol Motil 1999; 11: 93-99
21. Arnold M, Mura A, Langhans W, Geary N. Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 2006; 26: 11052-11060
22. Smith GP, Jerome C, Norgren R. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol 1985; 249: R638-R641
23. Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987; 2: 1300-1304
24. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985; 89: 1070-1077
25. Jordi J, Herzog B, Camargo SM, Boyle CN, Lutz TA, Verrey F. Specific Amino Acids Inhibit Food Intake via the Area Postrema or Vagal Afferents. J Physiol 2013; 591: 5611-5621
26. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, et al. An aminoacid taste receptor. Nature 2002; 416: 199-202
27. Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Brauner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-Alpha-Amino acid receptor with preference for basic amino acids. Molecular Pharmacol 2005; 67: 589-597
28. Conigrave AD, Quinn SJ, Brown EM. L-Amino acid sensing by the extracellular Ca2+ - sensing receptor. Proc Natl Acad Sci USA 2000; 97: 4814-4819
29. Heijboer AC, Frans A, Lomecky M, Blankenstein MA. Analysis of glucagon-like peptide 1; what to measure? Clinica Chim Acta 2011; 412: 1191-1194
30. Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, et al. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 2006; 4: 223-233
31. Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab 2013; 2: 376-392
32. Lee S, Han KH, Nakamura Y, Kawakami S, Shimada K, Hayakawa T, et al. Dietary L-cysteine improves the antioxidative potential and lipid metabolism in rats fed a normal diet. Biosci Biotechnol Biochem 2013; 77: 1430-1434
33. Sawamoto O, Kyo S, Kaneda S, Harada M, Kishimoto S, Koshitani O, et al. Fourweek intravenous repeated dose toxicity study of L-cysteine in male rats. J Toxicol Sci 2003; 28: 95-107
34. Elshorbagy AK, Smith AD, Kozich V, Refsum H. Cysteine and Obesity. Obesity 2012; 20: 473-481
35. Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, Plummer JD, Smith AD, Drevon CA, et al. Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res 2011; 52: 104-112
36. Vidal K, Breuille D, Serrant P, Denis P, Glomot F, Bechereau F, et al. Long-Term cysteine fortification impacts cysteine/glutathione homeostasis and food intake in ageing rats. Eur J Nutr 2014; 53: 963-971
37. Blouet C, Mariotti F, Azzout-Marniche D, Mathe V, Mikogami T, Tome D, et al. Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Radic Biol Med 2007; 42: 1089-1097
38. Blouet C, Mariotti F, Mikogami T, Tome D, Huneau J-F. Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal. J Nutr Biochem 2007; 18: 519-524
39. Kaneko Y, Kimura Y, Kimura H, Niki I. L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 2006; 55: 1391-1397