Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition

Toxicological Sciences

Volumn 144, Issue 1, 2015, Pages 105-113

  Galluccio, Michele ^a   Pochini, Lorena ^a   Peta, Valentina ^a   Iannì, Maria ^a   Scalise, Mariafrancesca ^a   Indiveri, Cesare ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Acetylcholine; Ethylmercury; Liposomes; Methylmercury; Mutagenesis; Toxicology

Indexed keywords

ACETYLCHOLINE; ACETYLCYSTEINE; BROMIDE; CYSTEINE; DITHIOERYTHRITOL; MERCURY; MERCURY DERIVATIVE; MUTANT PROTEIN; ORGANIC CATION TRANSPORTER 1; PROTEOLIPOSOME; TETRYLAMMONIUM CHLORIDE; CADMIUM CHLORIDE; MERCURIC CHLORIDE; METHYLMERCURIC CHLORIDE; METHYLMERCURY DERIVATIVE; ORGANIC CATION TRANSPORTER; RECOMBINANT PROTEIN; SLC22A4 PROTEIN, HUMAN; TETRYLAMMONIUM; THIOMERSAL;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ESCHERICHIA COLI; IC50; MUTANT; NONHUMAN; PROTEIN TRANSPORT; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; GENETICS; GENOTYPE; HUMAN; KINETICS; METABOLISM; MUTATION; PHENOTYPE; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; TRANSPORT AT THE CELLULAR LEVEL;

ESCHERICHIA COLI;

ACETYLCHOLINE; BIOLOGICAL TRANSPORT; CADMIUM CHLORIDE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HUMANS; KINETICS; MERCURIC CHLORIDE; METHYLMERCURY COMPOUNDS; MODELS, MOLECULAR; MUTATION; ORGANIC CATION TRANSPORT PROTEINS; PHENOTYPE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAETHYLAMMONIUM; THIMEROSAL;

EID: 84924478472     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu259     Document Type: Article

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