MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Yang, Xue Wei ^a   Shen, Guan Zhu ^b,c   Cao, Liang Qi ^a   Jiang, Xiao Feng ^a   Peng, He Ping ^a   Shen, Gang ^d   Chen, De ^a   Xue, Ping ^a  

^a Medical University   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c Collaborative Innovation Center for Cancer Medicine   (China)

^d Guangzhou Women and Children's Medical Center   (China)

Author keywords

FOXO1; Hepatocellular cancer; miR 1269; Proliferation

Indexed keywords

CYCLIN D1; KI 67 ANTIGEN; MICRORNA; MICRORNA 1269; PROTEIN P21; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; MIRN1269 MICRORNA, HUMAN;

ARTICLE; CARCINOGENICITY; CELL CYCLE PROGRESSION; CELL FATE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUCIFERASE ASSAY; MOLECULAR PATHOLOGY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TUMOR PROMOTION; UPREGULATION; WESTERN BLOTTING; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; PATHOLOGY; PROMOTER REGION; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICRORNAS; PROMOTER REGIONS, GENETIC;

EID: 84924425362     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-909     Document Type: Article

References (29)

1. Willatt JM, Francis IR, Novelli PM, Vellody R, Pandya A, Krishnamurthy VN: Interventional therapies for hepatocellular carcinoma. Cancer Imaging 2012, 12:79-88. 10.1102/1470-7330.2012.0011
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011,61(2):69-90. 10.3322/caac.20107
3. Lei J, Yan L: Comparison between living donor liver transplantation recipients who met the Milan and UCSF criteria after successful downstaging therapies. J Gastrointest Surg 2012,16(11):2120-2125. 10.1007/s11605-012-2019-y
4. Ambros V: The functions of animal microRNAs. Nature 2004,431(7006):350-355. 10.1038/nature02871
5. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004,116(2):281-297. 10.1016/S0092-8674(04)00045-5
6. Macfarlane LA, Murphy PR: MicroRNA: biogenesis, function and role in cancer. Curr Genomics 2010,11(7):537-561. 10.2174/138920210793175895
7. Graves P, Zeng Y: Biogenesis of mammalian microRNAs: a global view. Genomics Proteomics Bioinform 2012,10(5):239-245. 10.1016/j.gpb.2012.06.004
8. Kim VN, Nam JW: Genomics of microRNA. Trends Genet 2006,22(3):165-173. 10.1016/j.tig.2006.01.003
9. Olena AF, Patton JG: Genomic organization of microRNAs. J Cell Physiol 2010,222(3):540-545.
10. Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 2006,6(11):857-866. 10.1038/nrc1997
11. Farazi TA, Hoell JI, Morozov P, Tuschl T: MicroRNAs in human cancer. Adv Exp Med Biol 2013, 774:1-20. 10.1007/978-94-007-5590-1_1
12. Henrici A, Montalbano R, Neureiter D, Krause M, Stiewe T, Slater EP, Quint K, Ocker M, Di Fazio P: The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines. Mol Carcinog 2013.
13. Di Fazio P, Montalbano R, Neureiter D, Alinger B, Schmidt A, Merkel AL, Quint K, Ocker M: Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines. Exp Cell Res 2012,318(15):1832-1843. 10.1016/j.yexcr.2012.04.018
14. Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA: Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002,22(7):2111-2123. 10.1128/MCB.22.7.2111-2123.2002
15. Tzivion G, Dobson M, Ramakrishnan G: FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta 2011,1813(11):1938-1945. 10.1016/j.bbamcr.2011.06.002
16. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, De Pinho RA: FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007,128(2):309-323. 10.1016/j.cell.2006.12.029
17. Greer EL, Brunet A: FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005,24(50):7410-7425. 10.1038/sj.onc.1209086
18. Calnan DR, Brunet A: The FoxO code. Oncogene 2008,27(16):2276-2288. 10.1038/onc.2008.21
19. Myatt SS, Lam EW: The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007,7(11):847-859. 10.1038/nrc2223
20. Xie L, Ushmorov A, Leithauser F, Guan H, Steidl C, Farbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, Möller P, Wirth T: FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood 2012,119(15):3503-3511. 10.1182/blood-2011-09-381905
21. Stittrich AB, Haftmann C, Sgouroudis E, Kuhl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N: The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 2010,11(11):1057-1062. 10.1038/ni.1945
22. Guttilla IK, White BA: Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem 2009,284(35):23204-23216. 10.1074/jbc. M109.031427
23. Wu L, Li H, Jia CY, Cheng W, Yu M, Peng M, Zhu Y, Zhao Q, Dong YW, Shao K, Wu A, Wu XZ: MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett 2012,586(7):1038-1043. 10.1016/j.febslet.2012.02.050
24. Wu Z, Sun H, Zeng W, He J, Mao X: Upregulation of MircoRNA-370 induces proliferation in human prostate cancer cells by downregulating the transcription factor FOXO1. PLoS One 2012,7(9):e45825. 10.1371/journal.pone.0045825
25. Lu H, Liu P, Pan Y, Huang H: Inhibition of cyclin-dependent kinase phosphorylation of FOXO1 and prostate cancer cell growth by a peptide derived from FOXO1. Neoplasia 2011,13(9):854-863.
26. Ho KK, Myatt SS, Lam EW: Many forks in the path: cycling with FoxO. Oncogene 2008,27(16):2300-2311. 10.1038/onc.2008.23
27. Medema RH, Kops GJ, Bos JL, Burgering BM: AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000,404(6779):782-787. 10.1038/35008115
28. Schmidt M, Fernandez De Mattos S, van der Horst A, Klompmaker R, Kops GJ, Lam EW, Burgering BM, Medema RH: Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol 2002,22(22):7842-7852. 10.1128/MCB.22.22.7842-7852.2002
29. Dalmasso G, Nguyen HT, Yan Y, Laroui H, Srinivasan S, Sitaraman SV, Merlin D: MicroRNAs determine human intestinal epithelial cell fate. Differentiation 2010,80(2-3):147-154.