메뉴 건너뛰기




Volumn 53, Issue 5, 2015, Pages 739-745

Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice

Author keywords

Depression; Forced swimming test; Open field test; Tail suspension test

Indexed keywords

AMINOGUANIDINE; FLUOXETINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SILYMARIN; ANTIDEPRESSANT AGENT;

EID: 84924420096     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2014.942787     Document Type: Article
Times cited : (18)

References (68)
  • 1
    • 77953023898 scopus 로고    scopus 로고
    • Down regulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis
    • Bannwart CF, Nakaira-Takahagi E, Golim MA, et al. (2010). Down regulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis. Life Sci 86:880-6.
    • (2010) Life Sci , vol.86 , pp. 880-886
    • Bannwart, C.F.1    Nakaira-Takahagi, E.2    Golim, M.A.3
  • 2
    • 85006581093 scopus 로고    scopus 로고
    • Silymarin: A flavolignan with antidepressant activity
    • Bansal N, Gill R, Gupta GD. (2013). Silymarin: A flavolignan with antidepressant activity. J Pharm Innov 5:93-8.
    • (2013) J Pharm Innov , vol.5 , pp. 93-98
    • Bansal, N.1    Gill, R.2    Gupta, G.D.3
  • 3
    • 38049081662 scopus 로고    scopus 로고
    • Major depressive disorder
    • Belmaker RH, Agam G. (2008). Major depressive disorder. N Engl J Med 358:55-68.
    • (2008) N Engl J Med , vol.358 , pp. 55-68
    • Belmaker, R.H.1    Agam, G.2
  • 4
    • 78649938042 scopus 로고    scopus 로고
    • Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
    • Berk M, Kapczinski F, Andreazza AC, et al. (2011). Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 353:804-17.
    • (2011) Neurosci Biobehav Rev , vol.353 , pp. 804-817
    • Berk, M.1    Kapczinski, F.2    Andreazza, A.C.3
  • 5
    • 79953662385 scopus 로고    scopus 로고
    • Immune system to brain signaling neuropsychopharmacological implications
    • Capuron L, Miller AH. (2011). Immune system to brain signaling neuropsychopharmacological implications. Pharmacol Ther 130: 226-38.
    • (2011) Pharmacol Ther , vol.130 , pp. 226-238
    • Capuron, L.1    Miller, A.H.2
  • 6
    • 3042609836 scopus 로고    scopus 로고
    • Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder
    • Chrapko WE, Jurasz P, Radomski MW, et al. (2004). Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biol Psychiatry 56:129-34.
    • (2004) Biol Psychiatry , vol.56 , pp. 129-134
    • Chrapko, W.E.1    Jurasz, P.2    Radomski, M.W.3
  • 7
    • 84924417240 scopus 로고    scopus 로고
    • Treated effect of silymarin on vascular function of aged rats: Dependant on nitric oxide pathway
    • Demirci B, Demir O, Dost T, Birincioglu M. (2014). Treated effect of silymarin on vascular function of aged rats: Dependant on nitric oxide pathway. Pharm Biol 52:453-7.
    • (2014) Pharm Biol , vol.52 , pp. 453-457
    • Demirci, B.1    Demir, O.2    Dost, T.3    Birincioglu, M.4
  • 9
    • 29444447660 scopus 로고    scopus 로고
    • Evaluation of antidepressant-like activity of glycyrrhizin in mice
    • Dhingra D, Sharma A. (2005). Evaluation of antidepressant-like activity of glycyrrhizin in mice. Indian J Pharmacol 37:390-4.
    • (2005) Indian J Pharmacol , vol.37 , pp. 390-394
    • Dhingra, D.1    Sharma, A.2
  • 10
    • 34247489688 scopus 로고    scopus 로고
    • Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice
    • Dhir A, Kulkarni SK. (2007a). Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice. Prog Neuropsychopharmacol Biol Psychiatry 31:921-5.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 921-925
    • Dhir, A.1    Kulkarni, S.K.2
  • 11
    • 34250895550 scopus 로고    scopus 로고
    • Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor
    • Dhir A, Kulkarni SK. (2007b). Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor. Eur J Pharmacol 30:177-85.
    • (2007) Eur J Pharmacol , vol.30 , pp. 177-185
    • Dhir, A.1    Kulkarni, S.K.2
  • 12
    • 0004116672 scopus 로고
    • Cambridge: Cambridge University Press
    • Finney DJ. (1971). Probit Analysis. Cambridge: Cambridge University Press.
    • (1971) Probit Analysis
    • Finney, D.J.1
  • 13
    • 13844266047 scopus 로고    scopus 로고
    • Repeated restraint stress induces oxidative damage in rat hippocampus
    • Fontella FU, Siqueira IR, Vasconcellos APS, et al. (2005). Repeated restraint stress induces oxidative damage in rat hippocampus. Neurochem Res 30:105-11.
    • (2005) Neurochem Res , vol.30 , pp. 105-111
    • Fontella, F.U.1    Siqueira, I.R.2    Vasconcellos, A.P.S.3
  • 14
    • 69549089774 scopus 로고    scopus 로고
    • Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain
    • Galhardi F, Mesquita K, Monserrat JM, Barros DM. (2009). Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain. Food Chem Toxicol 47:2655-60.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2655-2660
    • Galhardi, F.1    Mesquita, K.2    Monserrat, J.M.3    Barros, D.M.4
  • 15
    • 77950377037 scopus 로고    scopus 로고
    • NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test
    • Ghasemi M, Raza M, Dehpour AR. (2010). NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. J Psychopharmacol 244:585-94.
    • (2010) J Psychopharmacol , vol.244 , pp. 585-594
    • Ghasemi, M.1    Raza, M.2    Dehpour, A.R.3
  • 16
    • 84865560008 scopus 로고    scopus 로고
    • Oxidative stress and glutathione response in tissue cultures from persons with major depression
    • Gibson SA, Korade Z, Shelton RC. (2012). Oxidative stress and glutathione response in tissue cultures from persons with major depression. J Psychiatr Res 46:1326-32.
    • (2012) J Psychiatr Res , vol.46 , pp. 1326-1332
    • Gibson, S.A.1    Korade, Z.2    Shelton, R.C.3
  • 17
    • 0031732560 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors in affective disorders-I. Basic pharmacology
    • Goodnick PJ, Goldstein BJ. (1998). Selective serotonin reuptake inhibitors in affective disorders-I. Basic pharmacology. J Psychopharmacol 12(3 Suppl B):S5-20.
    • (1998) J Psychopharmacol , vol.12 , Issue.3 , pp. S5-20
    • Goodnick, P.J.1    Goldstein, B.J.2
  • 18
    • 2442478088 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test
    • Harkin A, Connor TJ, Burns MP, Kelly JP. (2004). Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. Eur Neuropsychopharmacol 14:274-81.
    • (2004) Eur Neuropsychopharmacol , vol.14 , pp. 274-281
    • Harkin, A.1    Connor, T.J.2    Burns, M.P.3    Kelly, J.P.4
  • 19
    • 0037151298 scopus 로고    scopus 로고
    • Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats
    • Heiberg IL, Wegener G, Rosenberg R. (2002). Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats. Behav Brain Res 134:479-84.
    • (2002) Behav Brain Res , vol.134 , pp. 479-484
    • Heiberg, I.L.1    Wegener, G.2    Rosenberg, R.3
  • 20
    • 51249100656 scopus 로고    scopus 로고
    • DETA/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippo-campal neurogenesis
    • Hua Y, Huang X-Y, Zhou L, et al. (2008). DETA/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippo-campal neurogenesis. Psychopharmacology 200:231-42.
    • (2008) Psychopharmacology , vol.200 , pp. 231-242
    • Hua, Y.1    Huang, X.-Y.2    Zhou, L.3
  • 21
    • 77957745068 scopus 로고    scopus 로고
    • Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension
    • Jesmin J, Rashid MS, Jamil H, et al. (2010). Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension. BMC Med Genom 3:45.
    • (2010) BMC Med Genom , vol.3 , pp. 45
    • Jesmin, J.1    Rashid, M.S.2    Jamil, H.3
  • 22
    • 42249107665 scopus 로고    scopus 로고
    • Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum marianum L. Seed in mice
    • Karimi G, Saradeghi Keisari M. (2007). Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum marianum L. seed in mice. J Med Plants 6:38-43.
    • (2007) J Med Plants , vol.6 , pp. 38-43
    • Karimi, G.1    Saradeghi Keisari, M.2
  • 23
    • 27644452327 scopus 로고    scopus 로고
    • Effects of potassium channel inhibitors in the forced swimming test: Possible involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway
    • Kaster MP, Ferreira PK, Santos ARS, Rodrigues ALS. (2005). Effects of potassium channel inhibitors in the forced swimming test: Possible involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway. Behav Brain Res 165:204-9.
    • (2005) Behav Brain Res , vol.165 , pp. 204-209
    • Kaster, M.P.1    Ferreira, P.K.2    Santos, A.R.S.3    Rodrigues, A.L.S.4
  • 25
    • 0016441620 scopus 로고
    • Les propriétés pharmacologiques de la silybine et de la silymarine
    • Lecomte J. (1975). Les propriétés pharmacologiques de la silybine et de la silymarine. Rev Med Liege XXX:110-14.
    • (1975) Rev Med Liege , vol.30 , pp. 110-114
    • Lecomte, J.1
  • 26
    • 0042345028 scopus 로고    scopus 로고
    • Upregulation of neurogenesis and reduction in functional deficits following administration of DEtA/NONOate, a nitric oxide donor, after traumatic brain injury in rats
    • Lu D, Mahmood A, Zhang R, Copp M. (2003). Upregulation of neurogenesis and reduction in functional deficits following administration of DEtA/NONOate, a nitric oxide donor, after traumatic brain injury in rats. J Neurosurg 99:351-61.
    • (2003) J Neurosurg , vol.99 , pp. 351-361
    • Lu, D.1    Mahmood, A.2    Zhang, R.3    Copp, M.4
  • 27
    • 74449084200 scopus 로고    scopus 로고
    • Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment
    • Lu P, Mamiya T, Lu L, et al. (2009a). Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res 207:387-93.
    • (2009) Behav Brain Res , vol.207 , pp. 387-393
    • Lu, P.1    Mamiya, T.2    Lu, L.3
  • 28
    • 70349337734 scopus 로고    scopus 로고
    • Silibinin prevents amyloid peptide-induced memory impairment and oxidative stress in mice
    • Lu P, Mamiya T, Lu LL, et al. (2009b). Silibinin prevents amyloid peptide-induced memory impairment and oxidative stress in mice. Br J Pharmacol 157:1270-7.
    • (2009) Br J Pharmacol , vol.157 , pp. 1270-1277
    • Lu, P.1    Mamiya, T.2    Lu, L.L.3
  • 29
    • 61749095501 scopus 로고    scopus 로고
    • Effects of chronic mild stress on the oxidative parameters in the rat brain
    • Lucca G, Comim CM, Valvassori SS, et al. (2009). Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochem Int 54:358-62.
    • (2009) Neurochem Int , vol.54 , pp. 358-362
    • Lucca, G.1    Comim, C.M.2    Valvassori, S.S.3
  • 30
    • 36248961153 scopus 로고    scopus 로고
    • Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression
    • Luo CX, Zhu XJ, Zhou QG, et al. (2007). Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem 103:1872-82.
    • (2007) J Neurochem , vol.103 , pp. 1872-1882
    • Luo, C.X.1    Zhu, X.J.2    Zhou, Q.G.3
  • 31
    • 0037717094 scopus 로고    scopus 로고
    • Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: Evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway
    • Mantovani M, Pértile R, Calixto JB, et al. (2003). Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: Evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric oxide pathway. Neurosci Lett 343:1-4.
    • (2003) Neurosci Lett , vol.343 , pp. 1-4
    • Mantovani, M.1    Pértile, R.2    Calixto, J.B.3
  • 32
    • 0031786443 scopus 로고    scopus 로고
    • Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells
    • Mazzio E, Harris N, Soliman K. (1998). Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med 64:603-6.
    • (1998) Planta Med , vol.64 , pp. 603-606
    • Mazzio, E.1    Harris, N.2    Soliman, K.3
  • 33
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller AH, Maletic V, Raison CL. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol Psychiatry 659:732-41.
    • (2009) Biol Psychiatry , vol.659 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 34
    • 33745617042 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: Results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
    • Muller N, Schwarz MJ, Dehning S, et al. (2006). The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: Results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 117:680-4.
    • (2006) Mol Psychiatry , vol.117 , pp. 680-684
    • Muller, N.1    Schwarz, M.J.2    Dehning, S.3
  • 35
    • 78649763592 scopus 로고    scopus 로고
    • Silymarin attenuated the amyloid b plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model
    • Murata N, Murakami K, Ozawa Y, et al. (2010). Silymarin attenuated the amyloid b plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Biosci Biotechnol Biochem 74: 2299-306.
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 2299-2306
    • Murata, N.1    Murakami, K.2    Ozawa, Y.3
  • 36
    • 0026006786 scopus 로고
    • Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase enzyme
    • Muzes G, Deak G, Lang I, et al. (1991). Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase enzyme. Acta Physiol Hung 78:3-9.
    • (1991) Acta Physiol Hung , vol.78 , pp. 3-9
    • Muzes, G.1    Deak, G.2    Lang, I.3
  • 37
    • 33846345425 scopus 로고    scopus 로고
    • Protective effect of silymarin on oxidative stress in rat brain
    • Nencini C, Giorgi G, Micheli L. (2007). Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine 14:129-35.
    • (2007) Phytomedicine , vol.14 , pp. 129-135
    • Nencini, C.1    Giorgi, G.2    Micheli, L.3
  • 38
    • 40549126636 scopus 로고    scopus 로고
    • Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: A double-blind, randomized, placebo-controlled study
    • Nery FG, Monkul ES, Hatch JP, et al. (2008). Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: A double-blind, randomized, placebo-controlled study. Hum Psychopharmacol 232:87-94.
    • (2008) Hum Psychopharmacol , vol.232 , pp. 87-94
    • Nery, F.G.1    Monkul, E.S.2    Hatch, J.P.3
  • 39
    • 50849139232 scopus 로고    scopus 로고
    • Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications
    • Ng F, Berk M, Dean O, Bush AI. (2008). Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications. Int J Neuropsychopharmacol 11:851-76.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 851-876
    • Ng, F.1    Berk, M.2    Dean, O.3    Bush, A.I.4
  • 40
    • 10344229451 scopus 로고    scopus 로고
    • Alterations in regional brain neurotransmitters by silymarin, a natural antioxidant flavonoid mixture, in BALB/c mice
    • Osuchowski M, Johnson V, He Q, Sharma R. (2004). Alterations in regional brain neurotransmitters by silymarin, a natural antioxidant flavonoid mixture, in BALB/c mice. Pharm Biol 42:384-9.
    • (2004) Pharm Biol , vol.42 , pp. 384-389
    • Osuchowski, M.1    Johnson, V.2    He, Q.3    Sharma, R.4
  • 41
    • 84897858614 scopus 로고    scopus 로고
    • Effects of ketamine and N-methyl-D-aspartate on fluoxetine-induced antidepressant-related behavior using the forced swimming test
    • Owolabi RA, Akanmu MA, Adeyemi OI. (2014). Effects of ketamine and N-methyl-D-aspartate on fluoxetine-induced antidepressant-related behavior using the forced swimming test. Neurosci Lett 566: 172-6.
    • (2014) Neurosci Lett , vol.566 , pp. 172-176
    • Owolabi, R.A.1    Akanmu, M.A.2    Adeyemi, O.I.3
  • 42
    • 84860194760 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress
    • Peng YL, Liu YN, Liu L, et al. (2012). Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. J Neuroinflammation 9:75. doi:10.1186/1742-2094-9-75.
    • (2012) J Neuroinflammation , vol.9 , pp. 75
    • Peng, Y.L.1    Liu, Y.N.2    Liu, L.3
  • 43
    • 0017651126 scopus 로고
    • Behavioral despair in mice: A primary screening test for antidepressants
    • Porsolt RD, Bertin A, Jalfre M. (1977). Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327-36.
    • (1977) Arch Int Pharmacodyn Ther , vol.229 , pp. 327-336
    • Porsolt, R.D.1    Bertin, A.2    Jalfre, M.3
  • 44
    • 33745002041 scopus 로고    scopus 로고
    • Prostate cancer chemoprevention by silybinin: Bench to bedside
    • Rana P, Agarwal S, Agarwal R. (2006). Prostate cancer chemoprevention by silybinin: Bench to bedside. Mol Carcinog 45:436-42.
    • (2006) Mol Carcinog , vol.45 , pp. 436-442
    • Rana, P.1    Agarwal, S.2    Agarwal, R.3
  • 45
    • 0032078089 scopus 로고    scopus 로고
    • Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells
    • Rauen U, de Groot H. (1998). Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells. Free Radic Biol Med 24:1316-23.
    • (1998) Free Radic Biol Med , vol.24 , pp. 1316-1323
    • Rauen, U.1    De Groot, H.2
  • 46
    • 79957888003 scopus 로고    scopus 로고
    • Effects of antidepressants on behavioral assessment in adolescent rats
    • Refaey El H, Amri HS, SSC-Psych. (2011). Effects of antidepressants on behavioral assessment in adolescent rats. Bahrain Med Bull 33:83-95.
    • (2011) Bahrain Med Bull , vol.33 , pp. 83-95
    • Refaey El, H.1    Amri, H.S.2
  • 47
    • 0033062722 scopus 로고    scopus 로고
    • Prevention by a silymarin/phospholipid compound of ethanol-induced social learning deficits in rats
    • Reid C, Edwards J, Wang M, et al. (1999). Prevention by a silymarin/phospholipid compound of ethanol-induced social learning deficits in rats. Planta Med 655:421-4.
    • (1999) Planta Med , vol.655 , pp. 421-424
    • Reid, C.1    Edwards, J.2    Wang, M.3
  • 48
    • 0037040031 scopus 로고    scopus 로고
    • Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus
    • Rodrigues ALS, Silva GL, Matteussi AS, et al. (2002). Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci 70: 1347-58.
    • (2002) Life Sci , vol.70 , pp. 1347-1358
    • Rodrigues, A.L.S.1    Silva, G.L.2    Matteussi, A.S.3
  • 49
    • 80051788403 scopus 로고    scopus 로고
    • Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway
    • Sadaghiani MS, Javadi-Paydar M, Gharedaghi MH, et al. (2011). Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway. Behav Brain Res 2242:336-43.
    • (2011) Behav Brain Res , vol.2242 , pp. 336-343
    • Sadaghiani, M.S.1    Javadi-Paydar, M.2    Gharedaghi, M.H.3
  • 50
    • 84861603829 scopus 로고    scopus 로고
    • Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
    • Salamone F, Galvano F, Cappello F, et al. (2012). Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. Transl Res 159:477-86.
    • (2012) Transl Res , vol.159 , pp. 477-486
    • Salamone, F.1    Galvano, F.2    Cappello, F.3
  • 51
    • 84861856558 scopus 로고    scopus 로고
    • Antioxidants as antidepressants: Fact or fiction
    • Scapagnini G, Davinelli S, Drago F, et al. (2012). Antioxidants as antidepressants: Fact or fiction. CNS Drugs 6:477-90.
    • (2012) CNS Drugs , vol.6 , pp. 477-490
    • Scapagnini, G.1    Davinelli, S.2    Drago, F.3
  • 52
    • 48649094823 scopus 로고    scopus 로고
    • Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macro-phages
    • Shanmugam K, Holmquist L, Steele M, et al. (2008). Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macro-phages. Mol Nutr Food Res 52:427-38.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 427-438
    • Shanmugam, K.1    Holmquist, L.2    Steele, M.3
  • 53
    • 85006615011 scopus 로고    scopus 로고
    • Evaluation of antidepressant like activity of silymarin in albino mice
    • Sharma U, Lahkar M, Lahon J. (2012). Evaluation of antidepressant like activity of silymarin in albino mice. IJAPR 11:1246-9.
    • (2012) IJAPR , vol.11 , pp. 1246-1249
    • Sharma, U.1    Lahkar, M.2    Lahon, J.3
  • 54
    • 84873715776 scopus 로고    scopus 로고
    • Protective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents
    • Shin JH, Lee CW, Oh SJ, et al. (2013). Protective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents. Food Chem Toxicol 55:353-7.
    • (2013) Food Chem Toxicol , vol.55 , pp. 353-357
    • Shin, J.H.1    Lee, C.W.2    Oh, S.J.3
  • 55
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb-and paraquat-induced Parkinson's disease phenotype in the mouse
    • Singhal NK, Srivastava G, Patel DK, et al. (2011). Melatonin or silymarin reduces maneb-and paraquat-induced Parkinson's disease phenotype in the mouse. J Pineal Res 50:97-109.
    • (2011) J Pineal Res , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3
  • 56
    • 84859766804 scopus 로고    scopus 로고
    • Role of the 5-HT1A serotonergic system in anxiolytic-like effects of silymarin
    • Solati J, Yaghmaei P, Mohammdadi K. (2012). Role of the 5-HT1A serotonergic system in anxiolytic-like effects of silymarin. Neurophysiology 44:49-55.
    • (2012) Neurophysiology , vol.44 , pp. 49-55
    • Solati, J.1    Yaghmaei, P.2    Mohammdadi, K.3
  • 57
    • 0021990491 scopus 로고
    • The tail suspension test: A new method for screening antidepressants in mice
    • Steru L, Chermat R, Thierry B, Simon P. (1985). The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berlin) 853:367-70.
    • (1985) Psychopharmacology (Berlin) , vol.853 , pp. 367-370
    • Steru, L.1    Chermat, R.2    Thierry, B.3    Simon, P.4
  • 58
    • 0034603412 scopus 로고    scopus 로고
    • Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease
    • Thomas T. (2000). Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease. Neurobiol Aging 21:343-8.
    • (2000) Neurobiol Aging , vol.21 , pp. 343-348
    • Thomas, T.1
  • 59
    • 39649096744 scopus 로고    scopus 로고
    • Mechanism of the antioxidant action of silybin and 2, 3-dehydrosilybin flavono-lignans: A joint experimental and theoretical study
    • Trouillas P, Marsal P, Svobodova A, et al. (2008). Mechanism of the antioxidant action of silybin and 2, 3-dehydrosilybin flavono-lignans: A joint experimental and theoretical study. J Phys Chem A 112:1054-63.
    • (2008) J Phys Chem A , vol.112 , pp. 1054-1063
    • Trouillas, P.1    Marsal, P.2    Svobodova, A.3
  • 60
    • 0016433509 scopus 로고
    • Untersuchungen zu pharmakody-namik, angriffspunkt und wirkungsmechanismsus von silymarin, dem antihepatotoxischen prinzip aus Silybum marianum (L.) Gaertn
    • Vogel G, Trost W, Braatz R. (1975). Untersuchungen zu pharmakody-namik, angriffspunkt und wirkungsmechanismsus von silymarin, dem antihepatotoxischen prinzip aus Silybum marianum (L.) Gaertn. Arzneimittelforschung 25:82-9.
    • (1975) Arzneimittelforschung , vol.25 , pp. 82-89
    • Vogel, G.1    Trost, W.2    Braatz, R.3
  • 61
    • 0344520448 scopus 로고    scopus 로고
    • Antidepressant-and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice
    • Volke V, Wegener G, Bourin M, Vasar E. (2003). Antidepressant-and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res 140: 141-7.
    • (2003) Behav Brain Res , vol.140 , pp. 141-147
    • Volke, V.1    Wegener, G.2    Bourin, M.3    Vasar, E.4
  • 62
    • 0016052252 scopus 로고
    • Chemistry and analysis of silymarin from Silybum marianum (L.) Gaertn
    • Wagner VH, Diesel P, Seitz M. (1974). Chemistry and analysis of silymarin from Silybum marianum (L.) Gaertn. Arzneimittelforschung 24:466-71.
    • (1974) Arzneimittelforschung , vol.24 , pp. 466-471
    • Wagner, V.H.1    Diesel, P.2    Seitz, M.3
  • 63
    • 39149100296 scopus 로고    scopus 로고
    • Prevention of chronic stress-induced depression like behavior by inducible nitric oxide inhibitor
    • Wang D, An SC, Zhang X. (2008). Prevention of chronic stress-induced depression like behavior by inducible nitric oxide inhibitor. Neurosci Lett 433:59-64.
    • (2008) Neurosci Lett , vol.433 , pp. 59-64
    • Wang, D.1    An, S.C.2    Zhang, X.3
  • 64
    • 0036906534 scopus 로고    scopus 로고
    • Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation
    • Wang MJ, Lin WW, Chen HL, et al. (2002). Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 1611: 2103-12.
    • (2002) Eur J Neurosci , vol.1611 , pp. 2103-2112
    • Wang, M.J.1    Lin, W.W.2    Chen, H.L.3
  • 65
    • 0034859659 scopus 로고    scopus 로고
    • Silymarin: A review of its clinical properties in the management of hepatic disorders
    • Wellington K, Jarvis B. (2001). Silymarin: A review of its clinical properties in the management of hepatic disorders. BioDrugs 15:465-89.
    • (2001) BioDrugs , vol.15 , pp. 465-489
    • Wellington, K.1    Jarvis, B.2
  • 66
    • 84858589259 scopus 로고    scopus 로고
    • Role of serotonergic system on modulation of depressogenic-like effects of silymarin
    • Yaghmaei P, Oryanb S, Mohammadia K, Solati J. (2012). Role of serotonergic system on modulation of depressogenic-like effects of silymarin. Iran J Pharm Res 111:331-7.
    • (2012) Iran J Pharm Res , vol.111 , pp. 331-337
    • Yaghmaei, P.1    Oryanb, S.2    Mohammadia, K.3    Solati, J.4
  • 67
    • 0034754052 scopus 로고    scopus 로고
    • A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats
    • Zhang R, Zhang L, Zhang Z. (2001). A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann Neurol 50:602-11.
    • (2001) Ann Neurol , vol.50 , pp. 602-611
    • Zhang, R.1    Zhang, L.2    Zhang, Z.3
  • 68
    • 33746310878 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation
    • Zhu XJ, Hua Y, Jiang J, et al. (2006). Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Neuroscience 141:827-35.
    • (2006) Neuroscience , vol.141 , pp. 827-835
    • Zhu, X.J.1    Hua, Y.2    Jiang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.