The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: An opportunity to improve the performance of antibiotics?

Phytotherapy Research

Volumn 29, Issue 3, 2015, Pages 466-473

  Tomás Menor, Laura ^a   Barrajón Catalán, Enrique ^a   Segura Carretero, Antonio ^b   Martí, Nuria ^a   Saura, Domingo ^a   Menéndez, Javier A ^c   Joven, Jorge ^d   Micol, Vicente ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^d HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

Author keywords

Cistus; ellagitannins; flavonols; punicalagin; Staphylococcus; synergy

Indexed keywords

ANTIBIOTIC AGENT; CISTUS SALVIIFOLIUS EXTRACT; ELLAGIC ACID; ELLAGIC ACID 7 XILOSIDE; ELLAGITANNIN; ELLAGITANNIN DERIVATIVE; EPIGALLOCATECHIN GALLATE; FLAVONOID; GLYCOSIDE; ISOQUERCITRIN; KAEMPFEROL DERIVATIVE; KAEMPFEROL GLYCOSIDE DERIVATIVE; MYRICETIN; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PUNICALAGIN; PUNICALAGIN GALLATE; PUNICALIN; QUERCETIN; QUERCETIN DIGLYCOSIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; POLYPHENOL; TANNIN; TUBERCULOSTATIC AGENT;

ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CISTUS; CISTUS SALVIIFOLIUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MIXTURE; DRUG POTENCY; DRUG POTENTIATION; GROWTH INHIBITION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; NONHUMAN; PROCESS OPTIMIZATION; STAPHYLOCOCCUS AUREUS; CHEMISTRY; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROBIAL SENSITIVITY TEST; TANDEM MASS SPECTROMETRY;

CISTUS; CISTUS SALVIIFOLIUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTITUBERCULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CISTUS; DRUG SYNERGISM; FLAVONOIDS; HYDROLYZABLE TANNINS; MICROBIAL SENSITIVITY TESTS; PLANT EXTRACTS; POLYPHENOLS; STAPHYLOCOCCUS AUREUS; TANDEM MASS SPECTROMETRY;

EID: 84924414341     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5296     Document Type: Article

References (39)

1. Barrajon-Catalan E, Fernandez-Arroyo S, Roldan C, et al., 2011. A systematic study of the polyphenolic composition of aqueous extracts deriving from several Cistus genus species: evolutionary relationship. Phytochem Anal 22 (4): 303-312.
2. Barrajon-Catalan E, Fernandez-Arroyo S, Saura D, et al., 2010. Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells. Food Chem Toxicol 48 (8-9): 2273-2282.
3. Barrajon-Catalan E, Herranz-Lopez M, Joven J, Segura-Carretero A, Alonso-Villaverde C, Menendez JA, Micol V,. 2014. Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties. Adv Exp Med Biol 824: 141-159.
4. Bedoya LM, Bermejo P, Abad MJ,. 2009. Anti-infectious activity in the Cistaceae family in the Iberian Peninsula. Mini Rev Med Chem 9 (5): 519-525.
5. Berenbaum MC,. 1989. What is synergy? Pharmacol Rev 41 (2): 93-141.
6. Betts JW, Kelly SM, Haswell SJ, 2011. Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia. Int J Antimicrob Agents 38 (5): 421-425.
7. Brehm-Stecher BF, Johnson EA,. 2003. Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrob Agents Chermother 47 (10): 3357-3360.
8. Chou TC,. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58 (3): 621-681.
9. Daglia M,. 2012. Polyphenols as antimicrobial agents. Curr Op Biotech 23 (2): 174-181.
10. Darvesh AS, Bishayee A,. 2013. Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer. Nutr Cancer 65 (3): 329-344.
11. EUCAST. 2000. European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).Terminology relating to methods for the determination of susceptibility of bacteria to antimicrobial agents. EUCAST definitive document.
12. Eumkeb G, Siriwong S, Phitaktim S, Rojtinnakorn N, Sakdarat S,. 2011. Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. J Appl Microbiol 112 (1): 55-64.
13. F'Guyer S, Afaq F, Mukhtar H,. 2003. Photochemoprevention of skin cancer by botanical agents. Photodermatol Photo 19 (2): 56-72.
14. Freeman BL, Eggett DL, Parker TL,. 2010. Synergistic and antagonistic interactions of phenolic compounds found in navel oranges. J Food Sci 75 (6): C570-C576.
15. Gertsch J,. 2011. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta Med 77 (11): 1086-1098.
16. Gilbert B, Ferreira Alves L,. 2003. Synergy in plant medicines. Curr Med Chem 10 (1): 13-20.
17. Hancock V, Dahl M, Vejborg RM, and, Klemm P,. 2010. Dietary plant components ellagic acid and tannic acid inhibit Escherichia coli biofilm formation. J Med Microbiol 59 (4): 496-498.
18. Herranz-Lopez M, Fernandez-Arroyo S, Perez-Sanchez A, et al., 2012. Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications. Phytomedicine 19 (3-4): 253-261.
19. Howell AB, DH D'Souza,. 2013. The pomegranate: effects on bacteria and viruses that influence human health. Evid Based Complement Alternat Med 2013: 606212-606222. http://www.ncbi.nlm.nih.gov/pubmed/23762148.
20. Hussin WA, El-Sayed WM,. 2011. Synergic interactions between selected botanical extracts and tetracycline against gram positive and gram negative bacteria. J Biol Chem 11 (7): 433-441.
21. Joray MB, ML Gonzalez, SM Palacios, MC Carpinella,. 2011. Antibacterial activity of the plant-derived compounds 23-methyl-6-O-desmethylauricepyrone and (Z, Z)-5-(trideca-4,7-dienyl)resorcinol and their synergy with antibiotics against methicillin-susceptible and -resistant Staphylococcus aureus. J Agric Food Chem 59 (21): 11534-11542.
22. Khandelwal AR, Hebert VY, Kleinedler JJ, et al., 2012. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr 142 (8): 1487-1494.
23. Lin RD, Chin YP, Lee MH,. 2005. Antimicrobial activity of antibiotics in combination with natural flavonoids against clinical extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. Phytother Res 19 (7): 612-617.
24. Machado TDB, Leal ICR, Amaral ACF, et al., 2002. Antimicrobial ellagitannin of Punica granatum fruits. J Braz Chem Soc 13 (5): 606-610.
25. Mandalari G, Bisignano C, D'Arrigo M, et al., 2010. Antimicrobial potential of polyphenols extracted from almond skins. Lett Appl Microbiol 51 (1): 83-89.
26. Newman DJ, Cragg GM,. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75 (3): 311-335.
27. Odds FC,. 2003. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother 52 (1): 1.
28. Ong KC, Khoo HE,. 1997. Biological effects of myricetin. Gen Pharmacol 29 (2): 121-126.
29. Qin C, Tan KL, Zhang CL, et al., 2012. What does it take to synergistically combine sub-potent natural products into drug-level potent combinations? PLoS One 7 (11): e49969.
30. Radulovic NS, Blagojevic PD, Stojanovic-Radic ZZ, Stojanovic NM,. 2013. Antimicrobial plant metabolites: structural diversity and mechanism of action. Curr Med Chem 20 (7): 932-952.
31. Ríos JL, and, Recio MC,. 2005. Medicinal plants and antimicrobial activity. J Ethnopharmacol 100 (1-2): 80-84.
32. Rosato A, Vitali C, De Laurentis N, Armenise D, Antonietta Milillo M,. 2007. Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin. Phytomedicine 14 (11): 727-732.
33. Seeram, NP, Adams LS, Henning SM, et al., 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 16 (6): 360-367.
34. Taguri, T, Tanaka T, Kouno I,. 2004. Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease. Biol Pharm Bull 27 (12): 1965-1969.
35. Taylor PW, (2013). Alternative Natural Sources for a New Generation of Antibacterial Agents. Int J Antimicrob Agents.
36. Tomás-Menor L, Morales-Soto A, Barrajón-Catalán E, et al., 2013. Correlation between the antibacterial activity and the composition of extracts derived from various Spanish Cistus species. Food Chem Toxicol 55: 313-322.
37. Trentin DS, Silva DB, Amaral MW, et al., 2013. Tannins possessing bacteriostatic effect impair Pseudomonas aeruginosa adhesion and biofilm formation. PLoS One 8 (6): e66257.
38. Vegara S, Funes L, Martí N, et al., 2011. Bactericidal activities against pathogenic bacteria by selected constituents of plant extracts in carrot broth. Food Chem 128 (4): 872-877.
39. Wagner H,. 2011. Synergy research: approaching a new generation of phytopharmaceuticals. Fitoterapia 82 (1): 34-37.