Conformational activation of ADAMTS13

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 52, 2014, Pages 18578-18583

  South, Kieron ^a   Luken, Brenda M ^a   Crawley, James T B ^a   Phillips, Rebecca ^a   Thomas, Mari ^a   Collins, Richard F ^b   Deforche, Louis ^c   Vanhoorelbeke, Karen ^c   Lane, David A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

ADAMTS13; Autoantibodies; TTP; VWF

Indexed keywords

VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; VON WILLEBRAND FACTOR;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; THROMBOTIC THROMBOCYTOPENIC PURPURA; TRANSMISSION ELECTRON MICROSCOPY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BLOOD; CHEMISTRY; ENZYMOLOGY; GENE DELETION; GENETICS; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ENZYME ACTIVATION; HUMANS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; PURPURA, THROMBOTIC THROMBOCYTOPENIC; SEQUENCE DELETION; VON WILLEBRAND FACTOR;

EID: 84924368044     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411979112     Document Type: Article

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