The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disorders

Journal of Endocrinological Investigation

Volumn 38, Issue 3, 2015, Pages 333-338

  Yegin, Z A ^a   Iyidir, O T ^a   Demirtas C ^a   SuyanI, E ^a   Yetkin, I ^a   Pasaotlu H ^a   Ilhan, C ^a   Sucak, G T ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Diabetes mellitus; Ferritin; Hepcidin; Iron overload; Metabolic syndrome; Osteopontin

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIN 1; FERRITIN; HEPCIDIN; INTERLEUKIN 6; IRON; LEPTIN; NITRIC OXIDE SYNTHASE; OSTEOPONTIN; TRANSFERRIN;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; INFLAMMATION; IRON METABOLISM; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; BLOOD; CROSS-SECTIONAL STUDY; GLUCOSE INTOLERANCE; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PHYSIOLOGY; VASCULAR ENDOTHELIUM; YOUNG ADULT;

ADULT; AGED; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; ENDOTHELIUM, VASCULAR; FEMALE; FERRITINS; GLUCOSE INTOLERANCE; HEPCIDINS; HUMANS; INFLAMMATION; INTERLEUKIN-6; IRON; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OXIDATIVE STRESS; YOUNG ADULT;

EID: 84924347022     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0174-6     Document Type: Article

References (29)

1. Levesque J, Lamarche B (2008) The metabolic syndrome: definitions, prevalence and management. J Nutrigenet Nutrigenomics 1:100-108
2. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, International Diabetes Federation Task Force on Epidemiology and Prevention, National Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640-1645
3. Vykoukal D, Davies MG (2011) Vascular biology of metabolic syndrome. J Vasc Surg 54:819-831
4. Duvnjak L, Duvnjak M (2009) The metabolic syndrome-an ongoing story. J Physiol Pharmacol 60(Suppl 7):19-24
5. Tesauro M, Cardillo C (2011) Obesity, blood vessels and metabolic syndrome. Acta Physiol 203:279-286
6. Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G, Tenuti I, Lotto V, Friso S, Pizzolo F, Corrocher R (2005) Prevalence of body iron excess in the metabolic syndrome. Diabetes Care 28:2061-2063
7. Rasic-Milutinovic Z, Perunicic G, Pljesa S, Gluvic Z, Ilic M, Stokić E (2007) Metabolic syndrome in HD patients: association with body composition, nutritional status, inflammation and serum iron. Intern Med 46:945-951
8. Javanmard SH, Keyhanian K, Loghmani P, Samety AA, Haghdoost F, Rafiei L, Talaei M, Asgari S, Jazi MH, Sarrafzadegan N (2012) Association between heme oxygenase-1 gene promoter polymorphisms and metabolic syndrome in Iranians. Mol Biol Rep 39:3355-3360
9. Houschyar KS, Lüdtke R, Dobos GJ, Kalus U, Broecker-Preuss M, Rampp T, Brinkhaus B, Michalsen A (2012) Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial. BMC Med 10:54
10. Martinelli N, Traglia M, Campostrini N, Biino G, Corbella M, Sala C, Busti F, Masciullo C, Manna D, Previtali S, Castagna A, Pistis G, Olivieri O, Toniolo D, Camaschella C, Girelli D (2012) Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. PLoS One 7:e48250
11. Valenti L, Dongiovanni P, Motta BM, Swinkels DW, Bonara P, Rametta R, Burdick L, Frugoni C, Fracanzani AL, Fargion S (2011) Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations. Arterioscler Thromb Vasc Biol 31:683-690
12. Arredondo M, Fuentes M, Jorquera D, Candia V, Carrasco E, Leiva E, Mujica V, Hertrampf E, Pérez F (2011) Cross-talk between body iron stores and diabetes: iron stores are associated with activity and microsatellite polymorphism of the heme oxygenase and type 2 diabetes. Biol Trace Elem Res 143:625-636
13. Le Guenno G, Chanséaume E, Ruivard M, Morio B, Mazur A (2007) Study of iron metabolism disturbances in an animal model of insulin resistance. Diabetes Res Clin Pract 77:363-370
14. Kang HT, Linton JA, Shim JY (2012) Serum ferritin level is associated with the prevalence of metabolic syndrome in Korean adults: the 2007-2008 Korean National Health and Nutrition Examination Survey. Clin Chim Acta 413:636-641
15. Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, Liu Y, Lin X (2008) Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese. J Clin Endocrinol Metab 93:4690-4696
16. Valenti L, Swinkels DW, Burdick L, Dongiovanni P, Tjalsma H, Motta BM, Bertelli C, Fatta E, Bignamini D, Rametta R, Fargion S, Fracanzani AL (2011) Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 21:568-575
17. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790:671-681
18. Piperno A, Vergani A, Salvioni A, Trombini P, Viganò M, Riva A, Zoppo A, Boari G, Mancia G (2004) Effects of venesections and restricted diet in patients with the insulin-resistance hepatic iron overload syndrome. Liver Int 24:471-476
19. Datz C, Felder TK, Niederseer D, Aigner E (2013) Iron homeostasis in the metabolic syndrome. Eur J Clin Invest 43:215-224
20. Mateo-Gallego R, Calmarza P, Jarauta E, Burillo E, Cenarro A, Civeira F (2010) Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia. Metabolism 59:154-158
21. Cho GJ, Shin JH, Yi KW, Park HT, Kim T, Hur JY, Kim SH (2011) Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women. Menopause 18:1120-1124
22. Freixenet N, Vilardell C, Llauradó G, Giménez-Palop O, Berlanga E, Gutiérrez C, Caixàs A, Vendrell J, González-Clemente JM (2011) Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes. Diabetes Res Clin Pract 91:e33-e36
23. Campia U, Tesauro M, Cardillo C (2012) Human obesity and endothelium-dependent responsiveness. Br J Pharmacol 165:561-573
24. Guzik TJ, Mangalat D, Korbut R (2006) Adipocytokines-novel link between inflammation and vascular function? J Physiol Pharmacol 57:505-528
25. Komorowski J, Jankiewicz-Wika J, Kolomecki K, Cywinski J, Piestrzeniewicz K, Swiętoslawski J, Stepien H (2011) Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults. Cytokine 55:56-61
26. Stępień E, Wypasek E, Stopyra K, Konieczyńska M, Przybyło M, Pasowicz M (2011) Increased levels of bone remodeling biomarkers (osteoprotegerin and osteopontin) in hypertensive individuals. Clin Biochem 44:826-831
27. Uede T (2011) Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases. Pathol Int 61:265-280
28. YIlmaz Y (2012) Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions? Aliment Pharmacol Ther 36:815-823
29. Berezin AE, Kremzer AA (2013) Circulating osteopontin as a marker of early coronary vascular calcification in type two diabetes mellitus patients with known asymptomatic coronary artery disease. Atherosclerosis 229:475-481