Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes

Diabetes Research and Clinical Practice

Volumn 91, Issue 2, 2011, Pages

  Freixenet, Núria ^a   Vilardell, Carme ^a   Llauradó, Gemma ^a   Giménez Palop, Olga ^a   Berlanga, Eugenio ^b   Gutiérrez, Cristina ^c   Caixàs, Assumpta ^a   Vendrell, Joan ^c   González Clemente, José Miguel ^a  

^a HOSPITAL DE SABADELL   (Spain)

^b PARC TAULÍ HOSPITAL UNIVERSITARI   (Spain)

^c HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

Author keywords

Insulin secretion; Insulin sensitivity; Iron overload; Metabolic syndrome; Type 2 diabetes

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; IRON;

ADULT; AGED; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HYPERFERRITINEMIA; INSULIN SENSITIVITY; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; SOUTHERN EUROPE;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; FERRITINS; HUMANS; IRON OVERLOAD; MALE; MIDDLE AGED;

EID: 79952040420     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.10.003     Document Type: Article

References (18)

1. Swaminathan S., Fonseca V.A., Alam M.G., Shah S.V. The role of iron in diabetes and its complications. Diabetes Care 2007, 30:1926-1933.
2. Fernández-Real J.M., López-Bermejo A., Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002, 51:2348-2354.
3. Fernández-Real J.M., Peñarroja G., Castro A., García-Bragado F., Hernández-Aguado I., Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes 2002, 51:1000-1004.
4. Hernández C., Lecube A., Carrera A., Simó R. Soluble transferrin receptors and ferritin in Type 2 diabetic patients. Diabetic Med 2005, 22:97-101.
5. Eshed I., Elis A., Lishner M. Plasma ferritin and type 2 diabetes mellitus: a critical review. Endocr Res 2001, 27:91-97.
6. Freixenet N., Remacha A., Berlanga E., Caixàs A., Giménez-Palop O., Blanco-Vaca F., et al. Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia. Clin Chim Acta 2008, 400:111-116.
7. Beard J. Iron status of free-living elderly individuals. Am J Clin Nutr 2001, 73:503-504.
8. Fleming D.J., Jacques P.F., Tucker K.L., Massaro J.M., D'Agostino R.B., Wilson P.W., et al. Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores. Am J Clin Nutr 2001, 73:638-646.
9. Bozzini C., Girelli D., Olivieri O., Martinelli N., Bassi A., De Matteis G., et al. Prevalence of body iron excess in the metabolic syndrome. Diabetes Care 2005, 28:2061-2063.
10. Salonen J.T., Nyyssönen K., Korpela H., Tuomilehto J., Seppänen R., Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992, 86:803-811.
11. Klipstein-Grobusch K., Koster J.F., Grobbee D.E., et al. Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study. Am J Clin Nutr 1999, 69:1231-1236.
12. Fernández-Real J.M., Peñarroja G., Castro A., García-Bragado F., López-Bermejo A., Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity. Diabetes Care 2002, 25:2249-2255.
13. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2008, 31(Suppl. 1):S55-S60.
14. Wallace T.M., Levy J.C., Matthews D.R. Use and abuse of HOMA modeling. Diabetes Care 2004, 27:1487-1495.
15. Remacha A.F., Sarda M.P., Parellada M., Ubeda J., Manteiga R. The role of serum transferrin receptor in the diagnosis of iron deficiency. Haematologica 1998, 83:963-966.
16. Altes A., Ruiz A., Barceló M.J., et al. Prevalence of the C282Y, H63D, and S65C mutations of the HFE gene in 1,146 newborns from a region of Northern Spain. Genet Test 2004, 8:407-410.
17. Prentki M., Nolan C.J. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006, 116:1802-1812.
18. Hu F.B. The iron-heart hypothesis: search for the ironclad evidence. JAMA 2007, 297:639-641.