The Obesity Phenotype in Children with Asthma

Paediatric Respiratory Reviews

Volumn 12, Issue 3, 2011, Pages 152-159

  Jensen, M E ^a,b   Collins, C E ^c   Gibson, P G ^a,b   Wood, L G ^a,b  

^a JOHN HUNTER HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Airway inflammation; Asthma; Clinical outcomes; Obesity; Systemic inflammation

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADIPOCYTE; ASTHMA; BODY MASS; BREATHING MUSCLE; CELL VOLUME; CHILD HEALTH; CROSS-SECTIONAL STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EOSINOPHIL; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; INNATE IMMUNITY; INSULIN RESISTANCE; LUNG FUNCTION; OBESITY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INFLAMMATION; REVIEW; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ADIPONECTIN; ADOLESCENT; ASTHMA; C-REACTIVE PROTEIN; CHILD; COMORBIDITY; HUMANS; INFLAMMATION; LEPTIN; OBESITY; PHENOTYPE; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 79959695209     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2011.01.009     Document Type: Review

References (63)

1. Masoli M, Fabian D, Holt S, Beasley R. Global Burden of Asthma: Global Initiative for Asthma; 2004.
2. Australian Centre for Asthma Monitoring Asthma in Australia 2008 2008, Australian Institute of Health and Welfare, Canberra.
3. World Health Organisation. Obesity and overweight. Global Strategy on Diet, Physical Activity and Health 2003 [cited 14/07/2009]; Available from: http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/print.html.
4. Commonwealth Scientific Industrial Research Organisation (CSIRO) Preventative Health National Research Flagship, The University of South Australia. 2007 Australian National Children's Nutrition and Physical Activity Survey Main Findings; 2008.
5. Luder E., Melnik T.A., DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr. April 1998, 132:699-703.
6. van Gent R., van der Ent C., Rovers M., Kimpen J., van Essen-Zandvliet L., de Meer G. Excessive body weight is associated with additional loss of quality of life in children with asthma. J Allergy Clin Immunol. 2007, 119:591-596.
7. Gold D., Damokosh A., Dockery D., Berkey C. Body-Mass Index as a Predictor of Incident Asthma in a Prospective Cohort of Children. Pediatr Pulmonol. 2003, 36:514-521.
8. Gilliland F., Berhane K., Islam T., McConnell R., Gauderman W.J., Gilliland S., et al. Obesity and the Risk of Newly Diagnosed Asthma in School-age Children. Am J Epidemiol. 2003, 158:406-415.
9. Castro-Rodriguez J.A., Holberg C.J., Morgan W.J., Wright A.L., Martinez F.D. Increased Incidence of Asthmalike Symptoms in Girls Who Become Overweight or Obese During the School Years. Am J Respir Crit Care Med. 2001, 163:1344-1349.
10. Australian Centre for Asthma Monitoring. Asthma in Australian children: findings from Growing Up in Australia, the Longitudinal Study of Australian Children. Canberra; 2009.
11. Appleton S.L., Adams R.J., Wilson D.H., Taylor A.W., Ruffin R.E. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. Journal of Allergy and Clinical Immunology. 2006, 118:1284-1291.
12. von Mutius E., Schwartz J., Neas L.M., Dockery D., Weiss S.T. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001, 56:835-838.
13. Jarvis D., Chinn S., Potts J., Burney P. Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey. Clin Exp Allergy. 2002 Jun, 32:831-837.
14. Haldar P., Pavord I.D., Shaw D.E., Berry M.A., Thomas M., Brightling C.E., et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008 Aug 1, 178:218-224.
15. Pavord I.D., Brightling C.E., Woltmann G., Wardlaw A.J. Non-eosinophilic corticosteroid unresponsive asthma. Lancet. 1999, 353:2213-2214.
16. Peters-Golden M., Swern A., Bird S.S., Hustad C.M., Grant E., Edelman J.M. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006, 27:495-503.
17. Kershaw E., Flier J. Adipose Tissue as an Endocrine Organ. J Clin Endocrinol Metab. 2004, 89:2548-2556.
18. Fantuzzi G., Adipose tissue adipokines, and inflammation. J Allergy Clin Immunol. 2005, 115:911-919.
19. Shore S., Johnston R. Obesity and Asthma. Pharmacol Ther 2006, 110:83-102.
20. Auygun A., Gungor S., Ustundag B., Gurgoze M., Sen Y. Proinflammatory Cytokines and Leptin Are Increased in Serum of Prepubertal Obese Children. Mediators Inflamm 2005, 3:180-183.
21. Ustundag B., Gungor S., Aygun A., Turgut M., Yilmaz E. Oxidative status and serum leptin levels in obese prepubertal children. Cell Biochem Funct 2007, 25:479-483.
22. Valle M., Martos R., Gascón F., Cañete R., Zafra M., Morales R. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab. 2005, 31:55-62.
23. Balagopal P., George D., Yarandi H., Funanage V., Bayne E. Reversal of Obesity-Related Hypoadiponectinemia by Lifestyle Intervention: A Controlled, Randomized Study in Obese Adolescents. J Clin Endocrinol Metab 2005, 90:6192-6197.
24. Shin J.Y., Kim S.Y., Jeung M.J., Eun S.H., Woo C.W., Yoon S.-Y., et al. Serum Adiponectin, C-Reactive Protein and TNF-alpha levels in Obese Korean Children. J Pediatr Endocrinol Metab 2008, 21:23-29.
25. Kim K.W., Shin Y.H., Lee K.E., Kim E.S., Sohn M.H., Kim K.-E. Relationship between adipokines and manifestations of childhood asthma. Pediatric Allergy & Immunology 2008 Sep, 19:535-540.
26. Retnakaren R., Hanley A., Connelly P., Harris S., Zinman B. Elevated C-Reactive protein in Native Canadian children: an ominous early complication of childhood obesity. Diabetes Obes Metab 2006, 8:483-491.
27. Schwarzenberg S., Sinaiko A. Obesity and inflammation in children. Paediatr Respir Rev 2006, 7:239-246.
28. Balagopal P., George D., Patton N., Yarandi H., Roberts M., Bayne E., et al. Lifestyle-only Intervention Attenuates the Inflammatory State Associated with Obesity: A Controlled Randomised Study in Adolescents. J Pediatr 2005, 146:342-348.
29. Brasil A., Norton R., Rossetti M., Leão E., Mendes R. C-reactive protein as an indicator of low intensity inflammation in children and adolescents with and without obesity. Jornal de Pediatria. 2007, 83:477-480.
30. Reinher T., Stoffel-Wagner B., Roth C., Andler W. High-sensitive C-reactive protein, tumour necrosis factor α, and cardiovascular risk factors before and after weight loss in obese children. Metabolism 2005, 54:1155-1161.
31. Gallistatl S., Sudi K., Aigner R., Borkenstein M. Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int J Obes 2001, 25:1640-1643.
32. Maffeis C., Silvagni D., Bonadonna R., Grezzani A., Banzato C., Tato L. Fat cell size, insulin sensitivity, and inflammation in obese children. J Pediatr. 2007, 151:647-652.
33. Velloso L.A., Araujo E.P., de Souza C.T. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation. 2008, 15:189-193.
34. Lovett C., Whitehead B., Gibson P. Eosinophilic airway inflammation and the prognosis of childhood asthma. Clin Exp Allergy. 2007, 37:1594-1601.
35. Wood L., Scott H., Garg M., Gibson P. Innate immune mechanisms linking non-esterified fatty acids and respiratory disease. Prog Lipid Res 2008.
36. Gibson P., Simpson J., Saltos N. Heterogeneity of airway inflammation in persistent asthma. Chest 2001, 119:1329-1336.
37. Huang F, del R, o-Navarro BE, Sienra Monge JJ, Luis, Torres A, et al. Endothelial activation and systemic inflammation in obese asthmatic children. Allergy and Asthma Proceedings. 2008;29:453-60.
38. Guler N., Kirerleri E., Ones U., Tamay Z., Salmayenli N., Darendeliler F. Leptin: does it have any role in childhood asthma?. Journal of Allergy & Clinical Immunology 2004 Aug, 114(2):254-259.
39. Gurkan F., Atamar Y., Ece A., Kocyigit Y., Tuzun H., Mete N. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol 2004, 93:277-280.
40. Shin J.H., Kim J.H., Lee W.Y., Shim J.Y. The expression of adiponectin receptors and the effects of adiponectin and leptin on airway smooth muscle cells. Yonsei Med J 2008 Oct 31, 49:804-810.
41. Shore S.A., Schwartzman I.N., Mellema M.S., Flynt L., Imrich A., Johnston R.A. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005 Jan, 115:103-109.
42. Shore S.A., Rivera-Sanchez Y.M., Schwartzman I.N., Johnston R.A. Responses to ozone are increased in obese mice. J Appl Physiol 2003 Sep, 95:938-945.
43. Mancuso P., Huffnagle G.B., Olszewski M.A., Phipps J., Peters-Golden M. Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med. 2006 Jan 15, 173:212-218.
44. Jartti T., Saarikoski L., Jartti L., Lisinen I., Jula A., Huupponen R., et al. Obesity, adipokines and asthma. Allergy 2009 May 1, 64:770-777.
45. Mai X.-M., Böttcher M., Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004, 15:523-530.
46. Soferman R., Glatstein M., Sivan Y., Weisman Y. HsCRP levels: Measurement of airway infl ammation in asthmatic children. Pediatr Int 2008, 50:12-16.
47. Canoz M., Erdenen F., Uzun H., Muderrisoglu C., Aydin S. The relationship of inflammatory cytokines with asthma and obesity. Clinical & Investigative Medicine 2008 12, 31:E373-E379.
48. Kicic A., Sutanto E.N., Stevens P.T., Knight D.A., Stick S.M. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. American Journal of Respiratory & Critical Care Medicine 2006 Nov, 174:1110-1118.
49. Chedevergne F., Le Bourgeois M., de Blic J., Scheinmann P. The role of inflammation in childhood asthma. Arch Dis Child 2000, 82(Supp 2):ii6-ii9.
50. Halasz A., Cserhati E., Magyar P., KovÁCs M., Cseh K. Role of TNF- [alpha] and its 55 and 75 kDa receptors in bronchial hyperreactivity. Respir Med. 2002, 96:262-267.
51. Collins C., Warren J., Neve M., McCoy P., Stokes B. Measuring Effectiveness of Dietary Interventions in Child Obesity: A Systematic Review of Randomised Trials. Arch Pediatr Adolesc Med 2006, 160:906-922.
52. Baur LA, Fitzgerald DA, Armstrong GT, Bailey D, Batch J, Dixon J, et al. Recommendations for Bariatric Surgery in Adolescents in Australia and New Zealand: A paper from the Australian and New Zealand Association of Paediatric Surgeons, the Obesity Surgery Society of Australia and New Zealand and the Paediatric & Child Health Division of The Royal Australasian College of Physicians; March 2010.
53. Reinher T., Roth C., Alexy U., Kersting M., Kiess W., Andler W. Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents. Int J Obes 2005, 29:362-368.
54. Okely A.D., Collins C.E., Morgan P.J., Jones R.A., Warren J.M., Cliff D.P., et al. Multi-site randomized controlled trial of a child-centred physical activity program, a parent-centred dietary-modification program, or both in obese children: The HIKCUPS study. J Pediatr. 2010 Sep, 157(3):388-394.
55. Kelishadi R., Hashemi M., Mohammadifard N., Asgary S., Khavarian N. Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children. Clin Chem 2008, 54:147-153.
56. Eneli I.U., Skybo T., Camargo C.A. Weight loss and asthma: a systematic review. Thorax 2008 Aug, 63:671-676.
57. Cheng J., Pan T. Calorie controlled diet for chronic asthma. Cochrane Database Syst Rev 2003.
58. Stenius-Aarniala B., Poussa T., Kvarnstrom J., Gronlund E.L., Ylikahri M., Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000 Mar 25, 320:827-832.
59. Hakala K., Stenius-Aarniala B., Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest 2000 Nov, 118:1315-1321.
60. Johnson J.B., Summer W., Cutler R.G., Martin B., Hyun D.-H., Dixit V.D., et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med. 2007 Mar, 42:665-674.
61. Aaron S.D., Fergusson D., Dent R., Chen Y., Vandemheen K.L., Dales R.E. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004 Jun, 125:2046-2052.
62. Visser M., Bouter L.M., McQuillan G.M., Wener M.H., Harris T.B. Low-Grade Systemic Inflammation in Overweight Children. Paediatr 2001, 107:E13.
63. Reinher T., Roth C., Menke T., Andler W. Adiponectin before and after Weight Loss in Obese Children. J Clin Endocrinol Metab. 2004, 89:3790-3794.