The influence of leptin on Th1/Th2 balance in obese children with asthma;Influência da leptina no equilíbrio Th1/Th2 em crianças asmáticas obesas

Jornal Brasileiro de Pneumologia

Volumn 39, Issue 5, 2013, Pages 562-568

  Youssef, Doaa Mohammed ^a   Elbehidy, Rabab Mohamed ^a   Shokry, Dina Mahamoud ^a   Elbehidy, Eman Mohamed ^a  

^a ZAGAZIG UNIVERSITY   (Egypt)

Author keywords

Asthma; Interferon gamma; Interleukin 4; Leptin

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; LEPTIN;

ARTICLE; ASTHMA; BLOOD; CASE CONTROL STUDY; CHILD; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; MALE; OBESITY; PRESCHOOL CHILD; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TH1 TH2 BALANCE;

ASTHMA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; LEPTIN; MALE; OBESITY; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TH1-TH2 BALANCE;

EID: 84889667112     PISSN: 18063713     EISSN: 18063756     Source Type: Journal    
DOI: 10.1590/S1806-37132013000500006     Document Type: Article

References (30)

1. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-78. http://dx.doi.org/10.1183/09031936.00138707 PMid:18166595
2. Mohamed GM, Hafez HM. Innate immunity in obese asthmatic allergic and nonallergic adults. Egypt J Immunol. 2009;16(2):1-8. PMid:22059348
3. Sood A. Obesity, adipokines, and lung disease. J Appl Physiol. 2010;108(3):744-53. http://dx.doi.org/10.1152/japplphysiol.00838.2009 PMid:19926824 PMCid:PMC2838636
4. Stream AR, Sutherland ER. Obesity and asthma disease phenotypes. Curr Opin Allergy Clin Immunol. 2012;12(1):76-81. http://dx.doi.org/10.1097/ACI.0b013e32834eca41 PMid:22157152
5. Barranco P, Delgado J, Gallego LT, Bobolea I, Pedrosa M, García de Lorenzo A, et al. Asthma, obesity and diet [Article in Spanish]. Nutr Hosp. 2012;27(1):138-45. PMid:22566313
6. Ziora D, Sitek P, Machura E, Ziora K. Bronchial asthma in obesity--a distinct phenotype of asthma? [Article in Polish]. Pneumonol Alergol Pol. 2012;80(5):454-62. PMid:22926907
7. Malli F, Papaioannou AI, Gourgoulianis KI, Daniil Z. The role of leptin in the respiratory system: an overview. Respir Res. 2010;11:152. http://dx.doi.org/10.1186/1465-9921-11-152 PMid:21040518 PMCid:PMC2988727
8. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115(5):911-9; quiz 920. http://dx.doi.org/10.1016/j.jaci.2005.02.023 PMid:15867843
9. Schwarzenberg SJ, Sinaiko AR. Obesity and inflammation in children. Paediatr Respir Rev. 2006;7(4):239-46. http://dx.doi.org/10.1016/j.prrv.2006.08.002 PMid:17098638
10. Johnston RA, Theman TA, Lu FL, Terry RD, Williams ES, Shore SA. Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol. 2008;104(6):1727-35. http://dx.doi.org/10.1152/japplphysiol.00075.2008 PMid:18323466
11. Ali Assad N, Sood A. Leptin, adiponectin and pulmonary diseases. Biochimie. 2012;94(10):2180-9. http://dx.doi.org/10.1016/j.biochi.2012.03.006 PMid:22445899
12. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176(12):7745-52. PMid:16751422
13. Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, Greenway F, et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol. 2010;185(3):1836-45. http://dx.doi.org/10.4049/jimmunol.1000021 PMid:20581149
14. Wong N, Fam BC, Cempako GR, Steinberg GR, Walder K, Kay TW, et al. Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice. Endocrinology. 2011;152(10):3690-9. http://dx.doi.org/10.1210/en.2011-0288 PMid:21791564
15. Barlow SE, Dietz WH. Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services. Pediatrics. 1998;102(3):E29. http://dx.doi.org/10.1542/peds.102.3.e29 PMid:9724677
16. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Bethesda: National Institutes of Health; 2002.
17. Yeh KH, Skowronski ME, Coreno AJ, Seitz RE, Villalba KD, Dickey-White H, et al. Impact of obesity on the severity and therapeutic responsiveness of acute episodes of asthma. J Asthma. 2011;48(6):546-52. http://dx.doi.org/10.3109/02770903.2011.581733 PMid:21604921
18. Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol. 2008;19(6):535-40. http://dx.doi.org/10.1111/j.1399-3038.2007.00690.x PMid:18221467
19. Nagel G, Koenig W, Rapp K, Wabitsch M, Zoellner I, Weiland SK. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol. 2009;20(1):81-8. http://dx.doi.org/10.1111/j.1399-3038.2008.00740.x PMid:18331416
20. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol. 2005;115(1):103-9. http://dx.doi.org/10.1016/j.jaci.2004.10.007 PMid:15637554
21. Mito N, Kitada C, Hosoda T, Sato K. Effect of diet-induced obesity on ovalbumin-specific immune response in a murine asthma model. Metabolism. 2002;51(10):1241-6. http://dx.doi.org/10.1053/meta.2002.35196 PMid:12370841
22. Sin DD, Man SF. Impaired lung function and serum leptin in men and women with normal body weight: a population based study. Thorax. 2003;58(8):695-8. http://dx.doi.org/10.1136/thorax.58.8.695 PMCid:PMC1746780
23. Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol. 2004;93(3):277-80. http://dx.doi.org/10.1016/S1081-1206(10)61501-3
24. Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol. 2004;114(2):254-9. http://dx.doi.org/10.1016/j.jaci.2004.03.053 PMid:15316499
25. Mai XM, Böttcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol. 2004;15(6):523-30. http://dx.doi.org/10.1111/j.1399-3038.2004.00195.x PMid:15610366
26. Lord GM, Matarese G, Howard JK, Bloom SR, Lechler RI. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J Leukoc Biol. 2002;72(2):330-8. PMid:12149424
27. La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med (Berl). 2004;82(1):4-11. http://dx.doi.org/10.1007/s00109-003-0492-1 PMid:14556053
28. Fernandez-Real JM, Broch M, Vendrell J, Ricart W. Smoking, fat mass and activation of the tumor necrosis factor-alpha pathway. Int J Obes Relat Metab Disord. 2003;27(12):1552-6. http://dx.doi.org/10.1038/sj.ijo.0802472 PMid:12975637
29. Rastogi D, Canfield SM, Andrade A, Isasi CR, Hall CB, Rubinstein A, et al. Obesity-associated asthma in children: a distinct entity. Chest. 2012;141(4):895-905. http://dx.doi.org/10.1378/chest.11-0930 PMid:21980061
30. Yuksel H, Sogut A, Yilmaz O, Onur E, Dinc G. Role of adipokines and hormones of obesity in childhood asthma. Allergy Asthma Immunol Res. 2012;4(2):98-103. http://dx.doi.org/10.4168/aair.2012.4.2.98 PMid:22379605 PMCid:PMC3283800