Resistin-like molecule-β is a human airway remodelling mediator

European Respiratory Journal

Volumn 39, Issue 2, 2012, Pages 458-466

  Fang, C ^a   Meng, Q ^a   Wu, H ^a   Eid, G ^a   Zhang, G ^b   Zhang, X ^b   Yang, S ^b   Huang, K ^c   Lee, T H ^a   Corrigan, C J ^a   Ying, S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b JILIN UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Airways epithelial cells; Asthma; Mucus; Remodelling; Resistin like molecule

Indexed keywords

EPIDERMAL GROWTH FACTOR; INTERLEUKIN 13; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 5AC; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESISTIN LIKE MOLECULE BETA; SECRETORY PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AIRWAY REMODELING; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADULT; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIVISION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MUCIN 5AC; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY MUCOSA; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863012328     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00107811     Document Type: Article

References (30)

1. Steppan CM, Lazar MA. The current biology of resistin. J Intern Med 2004; 255: 439-447. (Pubitemid 38446357)
2. Asano T, Sakosda H, Fujishiro M, et al. Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance. Curr Diabetes Rev 2006; 2: 449-454. (Pubitemid 44734229)
3. Steppan CM, Brown EJ, Wright CM, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 2001; 98: 502-506. (Pubitemid 32105071)
4. Holcomb IN, Kabakoff RC, Chan B, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000; 19: 4046-4055. (Pubitemid 30608543)
5. Teng X, Li D, Champion HC, et al. FIZZ1/RELMα, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. Circ Res 2003; 92: 1065-1067. (Pubitemid 36665851)
6. Yang RZ, Huang Q, Xu A, et al. Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun 2003; 310: 927-935. (Pubitemid 37188711)
7. Mishra A, Wang M, Schlotman J, et al. Resistin-like molecule-β is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol 2007; 293: L305-L313. (Pubitemid 47205011)
8. McVay LD, Keilbaugh SA, Wong TM, et al. Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest 2006; 116: 2914-2923. (Pubitemid 44684476)
9. Angelini DJ, Su Q, Yamaji-Kegan K, et al. Resistin-like molecule-βin scleroderma-associated pulmonary hypertension. Am J Respir Cell Mol Biol 2009; 41: 553-561.
10. Ying S, O'Connor B, Ratoff J, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008; 181: 2790-2798.
11. Ying S, O'Connor B, Ratoff J, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005; 174: 8183-8190. (Pubitemid 40806330)
12. Steiling K, Kadar AY, Bergerat A, Flanigon J, et al. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One 2009; 4: e5043.
13. Corrigan CJ, Wang W, Meng Q, et al. T-helper cell type 2 (Th2) memory T cell-protentiating cytokine 25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci USA 2011; 108: 1579-1584.
14. Ikari A, Atomi K, Kinjo K, et al. Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sci 2010; 86: 766-773.
15. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNFalpha-converting enzyme. J Immunol 2005; 175: 4009-4016. (Pubitemid 41292063)
16. Carroll NG, Mutavdzic S, James AL. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax 2002; 57: 677-682. (Pubitemid 34864522)
17. Fahy JV. Goblet cell and mucin gene abnormalities in asthma. Chest 2002; 122: Suppl. 6, 320S-326S. (Pubitemid 36043022)
18. Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001; 163: 517-523. (Pubitemid 32158539)
19. Williams OW, Sharafkhaneh A, Kim V, et al. Airway mucus: from production to secretion. Am J Respir Cell Mol Biol 2006; 34: 527-536.
20. Ali MS, Pearson JP. Upper airway mucin gene expression: a review. Laryngoscope 2007; 117: 932-938. (Pubitemid 46699374)
21. Rousseau K, Kirkham S, McKane S, et al. Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus. Am J Physiol Lung Cell Mol Physiol 2007; 292: L1396-L1404. (Pubitemid 47078929)
22. Kirkham S, Sheehan JK, Knight D, et al. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J 2002; 361: 537-546. (Pubitemid 34177823)
23. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006; 86: 245-278.
24. Turner J, Jones CE. Regulation of mucin expression in respiratory diseases. Biochem Soc Trans 2009; 37: 877-881.
25. Sharma P, Dudus L, Nielsen PA, et al. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 1998; 19: 30-37. (Pubitemid 128354939)
26. Chu HW, Balzar S, Seedorf GJ, et al. Transforming growth factor-β2 induces bronchial epithelial mucin expression in asthma. Am J Pathol 2004; 165: 1097-1106. (Pubitemid 39297717)
27. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J 2008; 32: 1068-1081.
28. Lee CG, Link H, Baluk P, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004; 10: 1095-1103. (Pubitemid 39424871)
29. Kushiyama A, Shojima N, Ogihara T, et al. Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet. J Biol Chem 2005; 280: 42016-42025. (Pubitemid 43023170)
30. Liu T, Baek HA, Yu H, et al. FIZZ2/RELM-b induction and role in pulmonary fibrosis. J Immunol 2011; 187: 450-461.