Xuebijing injection reduces organ injuries and improves survival by attenuating inflammatory responses and endothelial injury in heatstroke mice

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Xu, Qiulin ^a,b   Liu, Jingxian ^a   Guo, Xiaohua ^c   Tang, Youqing ^a   Zhou, Gengbiao ^d   Liu, Yanan ^c   Huang, Qiaobing ^c   Geng, Yan ^a   Liu, Zhifeng ^a   Su, Lei ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b Postdoctoral Workstation Huabo Bio pharmaceutical Research Institute   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Endothelial injury; Heatstroke; Inflammatory responses; Xuebijing injection

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; CHINESE DRUG; CREATININE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EOSIN; FIBRINOGEN; HEMATOXYLIN; INTERLEUKIN 6; LACTATE DEHYDROGENASE; NITROGEN; PROTECTIVE AGENT; TROPONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA; VON WILLEBRAND FACTOR; XUEBIJING; CYTOKINE; HERBACEOUS AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHINESE MEDICINE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DENSE BODY; DOSE RESPONSE; ENDOTHELIUM INJURY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN BLOOD LEVEL; HEART INJURY; HEART MITOCHONDRION; HEAT STROKE; INFLAMMATION; INTERNATIONAL NORMALIZED RATIO; INTESTINE INJURY; KIDNEY INJURY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER INJURY; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PARTIAL THROMBOPLASTIN TIME; PROTECTION; PROTHROMBIN TIME; SURVIVAL RATE; THROMBIN TIME; THROMBOCYTE FUNCTION ANALYZER; TRANSMISSION ELECTRON MICROSCOPY; UREA NITROGEN BLOOD LEVEL; ANIMAL; BLOOD; BLOOD CLOTTING; C57BL MOUSE; DRUG EFFECTS; HEART; KIDNEY; LIVER; METABOLISM; MITOCHONDRION; MORTALITY; PATHOLOGY; PHYTOTHERAPY; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD COAGULATION; CYTOKINES; DRUGS, CHINESE HERBAL; E-SELECTIN; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEART; HEAT STROKE; INFLAMMATION; INTERLEUKIN-6; KIDNEY; LIVER; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; PHYTOTHERAPY; TUMOR NECROSIS FACTOR-ALPHA; VON WILLEBRAND FACTOR;

EID: 84924294988     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0519-5     Document Type: Article

References (35)

1. Yamakawa K, Matsumoto N, Imamura Y, Muroya T, Yamada T, Nakagawa J, et al. Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model. PLoS One. 2013;8(2):e56728.
2. Bouchama A, Knochel JP. Heat stroke. N Engl J Med. 2002;346(25):1978-88.
3. Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, Bouchama A. Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model. Arterioscler Thromb Vasc Biol. 2008;28(6):1130-6.
4. al-Mashhadani SA, Gader AG, al Harthi SS, Kangav D, Shaheen FA, Bogus F. The coagulopathy of heat stroke: alterations in coagulation and fibrinolysis in heat stroke patients during the pilgrimage (Haj) to Makkah. Blood Coagul Fibrinolysis. 1994;5(5):731-6.
5. el-Kassimi FA, Al-Mashhadani S, Abdullah AK, Akhtar J. Adult respiratory distress syndrome and isseminated intravascular coagulation complicating heat stroke. Chest. 1986;90(4):571-4.
6. Bouchama A, Roberts G, Al Mohanna F, El-Sayed R, Lach B, Chollet-Martin S, et al. Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol. 2005;98(2):697-705.
7. Leon LR, Helwig BG. Heat stroke: role of the systemic inflammatory response. J Appl Physiol. 2010;109(6):1980-8.
8. Hagiwara S, Iwasaka H, Goto K, Ochi Y, Mizunaga S, Saikawa T, et al. Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats. Shock. 2010;34(4):402-6.
9. Bouchama A, Kunzelmann C, Dehbi M, Kwaasi A, Eldali A, Zobairi F, et al. Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke. Arterioscler Thromb Vasc Biol. 2008;28(7):1318-25.
10. Wu WS, Chou MT, Chao CM, Chang CK, Lin MT, Chang CP. Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. Acta Pharmacol Sin. 2012;33(6):775-82.
11. Bouchama A, Kwaasi A, Dehbi M, Al Mohanna F, Eldali A, El-Sayed R, et al. Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons. Shock. 2007;27(5):578-83.
12. Yeo TP. Heat stroke: a comprehensive review. AACN Clin Issues. 2004;15(2):280-93.
13. Chen ZC, Kuo JR, Huang YP, Lin MT. Mu-opioid receptor blockade protects against circulatory shock and cerebral ischemia during heatstroke. J Cardiovasc Pharmacol. 2005;46(6):754-60.
14. Wang Q, Yao YM, Wang WJ, Xian LM, Dong N, Xu S, et al. Effect of Xuebijing injection on renal high mobility group box-1 protein expression and acute kidney injury in rats after scald injury. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007;29(4):478-83.
15. Gao YL, Chai YF, Yao YM. Advancement in the research of mechanism of immune dysfunction in sepsis and the regulatory effects of Xuebijing injection. Zhonghua Shao Shang Za Zhi. 2013;29(2):162-5.
16. Chen Y, Tong H, Zhang X, Tang L, Pan Z, Liu Z, et al. Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats. J Tradit Chin Med. 2013;33(2):243-9.
17. Jiang M, Zhou M, Han Y, Xing L, Zhao H, Dong L, et al. Identification of NF-kappaB Inhibitors in Xuebijing injection for sepsis treatment based on bioactivity-integrated UPLC-Q/TOF. J Ethnopharmacol. 2013;147(2):426-33.
18. Qi F, Liang ZX, She DY, Yan GT, Chen LA. A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients. J Tradit Chin Med. 2011;31(1):46-9.
19. Guo SS, Gao YJ, Tian XC, Jin YH, Liu FZ, Cui XL. Effect of xuebijing oral effervescent tablet on endotoxin induced fever and disseminated intravascular coagulation rabbit model. Yao Xue Xue Bao. 2013;48(8):1241-6.
20. Ji J, Zhou F, Yue H, Song Q. Protective mechanism of Xuebijing injection against heat stroke in rats. Exp Ther Med. 2014;7(6):1745-51.
21. Dehbi M, Uzzaman T, Baturcam E, Eldali A, Ventura W, Bouchama A. Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke. PLoS One. 2012;7(9):e44100.
22. Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, et al. Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock. 2005;24(4):332-5.
23. Lin MT, Liu HH, Yang YL. Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke. Am J Physiol. 1997;273(4 Pt 2):H2072-2077.
24. Liu CC, Chien CH, Lin MT. Glucocorticoids reduce interleukin-1 concentration and result in neuroprotective effects in rat heatstroke. J Physiol. 2000;527(Pt 2):333-43.
25. Chen CC, Chen ZC, Lin MT, Hsu CC. Activated protein C improves heatstroke outcomes through restoration of normal hypothalamic and thermoregulatory function. Am J Med Sci. 2009;338(5):382-7.
26. Hagiwara S, Iwasaka H, Matsumoto S, Hasegawa A, Yasuda N, Noguchi T. In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models. Shock. 2010;33(3):282-8.
27. Hagiwara S, Iwasaka H, Shingu C, Matsumoto S, Uchida T, Noguchi T. High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Inflamm Res. 2010;59(7):511-8.
28. Hall DM, Buettner GR, Oberley LW, Xu L, Matthes RD, Gisolfi CV. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. Am J Physiol Heart Circ Physiol. 2001;280(2):H509-521.
29. Tong H, Tang Y, Chen Y, Yuan F, Liu Z, Peng N, et al. HMGB1 activity inhibition alleviating liver injury in heatstroke. J Trauma Acute Care Surg. 2013;74(3):801-7.
30. Wang YB, Yao YM, Wang Q, Wang WJ. Effect of "Xuebijing injection" on expression of high mobility group box-1 protein and acute liver injury in rats with scald injury. Zhonghua Shao Shang Za Zhi. 2009;25(3):171-5.
31. Chavakis T, Kanczkowski W, Willenberg HS, Bornstein SR. Endothelial dysfunction: a critical determinant in inflammation-associated adrenal insufficiency? Eur J Clin Invest. 2011;41(8):917-9.
32. Girish KS, Paul M, Thushara RM, Hemshekhar M, Shanmuga Sundaram M, Rangappa KS, et al. Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage. Biochem Biophys Res Commun. 2013;438(1):198-204.
33. Hong S, Kim JY, Hwang J, Shin KS, Kang SJ. Heptachlor induced mitochondria-mediated cell death via impairing electron transport chain complex III. Biochem Biophys Res Commun. 2013;437(4):632-6.
34. Jayaprakasam B, Yang N, Wen MC, Wang R, Goldfarb J, Sampson H, et al. Constituents of the anti-asthma herbal formula ASHMITM synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro. J Integr Med. 2013;11(3):195-205.
35. Karki R, Park CH, Kim DW. Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7). J Integr Med. 2013;11(4):246-52.