Toll-Like Receptor 4 and High-Mobility Group Box 1 Are Critical Mediators of Tissue Injury and Survival in a Mouse Model for Heatstroke

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Dehbi, Mohammed ^a,c   Uzzaman, Taher ^a   Baturcam, Engin ^a   Eldali, Abdelmoneim ^a   Ventura, Wilhelmina ^a   Bouchama, Abderrezak ^b  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^c DASMAN DIABETES INSTITUTE   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HEAT STRESS; HEAT STROKE; IMMUNE RESPONSE; INFLAMMATION; LIVER INJURY; MORTALITY; MOUSE; MUTANT; NONHUMAN; PROTEIN FUNCTION; PROTEIN SECRETION; SURVIVAL; TISSUE INJURY; WILD TYPE;

ANIMALS; BIOLOGICAL MARKERS; BODY TEMPERATURE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HEAT STROKE; HMGB1 PROTEIN; HOT TEMPERATURE; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

ANIMALIA; MUS;

EID: 84866040117     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044100     Document Type: Article

References (37)

1. Robine JM, Cheung SL, Le Roy S, Van Oyen H, Griffiths C, et al. (2008) Death toll exceeded 70,000 in Europe during the summer of 2003. C R Biol 331: 171-178.
2. Semenza JC, Rubin CH, Falter KH, Selanikio JD, Flanders WD, et al. (1996) Heat-related deaths during the July 1995 heat wave in Chicago. N Engl J Med 335: 84-90.
3. Bouchama A, Knochel JP, (2002) Heat stroke. N Engl J Med 346: 1978-1988.
4. Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, et al. (2008) Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model. Arterioscler Thromb Vasc Biol 28: 1130-1136.
5. Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, et al. (2005) Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock 24: 332-335.
6. Bouchama A, Parhar RS, El-Yazigi A, Sheth K, Al-Sedairy S, (1991) Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J Appl Physiol 70: 2640-2644.
7. Chen CM, Hou CC, Cheng KC, Tian RL, Chang CP, et al. (2006) Activated protein C therapy in a rat heat stroke model. Crit Care Med 34: 1960-1966.
8. Lin MT, Liu HH, Yang YL, (1997) Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke. Am J Physiol 273: H2072-2077.
9. Leon LR, Helwig BG, (2010) Role of endotoxin and cytokines in the systemic inflammatory response to heat injury. Front Biosci (Schol Ed) 2: 916-938.
10. Bouchama A, Kunzelmann C, Dehbi M, Kwaasi A, Eldali A, et al. (2008) Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke. Arterioscler Thromb Vasc Biol 28: 1318-1325.
11. Bouchama A, Kwaasi A, Dehbi M, Al Mohanna F, Eldali A, et al. (2007) Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons. Shock 27: 578-583.
12. Liu CC, Chien CH, Lin MT, (2000) Glucocorticoids reduce interleukin-1 concentration and result in neuroprotective effects in rat heatstroke. J Physiol 527 Pt 2: 333-343.
13. Takeda K, Kaisho T, Akira S, (2003) Toll-like receptors. Annu Rev Immunol 21: 335-376.
14. Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
15. Tsung A, Klune JR, Zhang X, Jeyabalan G, Cao Z, et al. (2007) HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204: 2913-2923.
16. Zanotti G, Casiraghi M, Abano JB, Tatreau JR, Sevala M, et al. (2009) Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297: L52-63.
17. Oyama J, Blais C Jr, Liu X, Pu M, Kobzik L, et al. (2004) Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109: 784-789.
18. Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, et al. (2007) TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117: 2847-2859.
19. Andersson U, Tracey KJ (2010) HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection. Annu Rev Immunol.
20. Wittebole X, Castanares-Zapatero D, Laterre PF, (2010) Toll-like receptor 4 modulation as a strategy to treat sepsis. Mediators Inflamm 2010: 568396.
21. Jiang D, Liang J, Fan J, Yu S, Chen S, et al. (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11: 1173-1179.
22. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, et al. (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248-251.
23. Hagiwara S, Iwasaka H, Goto K, Ochi Y, Mizunaga S, et al. (2010) Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats. Shock 34: 402-406.
24. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, et al. (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189: 615-625.
25. Leon LR, DuBose DA, Mason CW, (2005) Heat stress induces a biphasic thermoregulatory response in mice. Am J Physiol Regul Integr Comp Physiol 288: R197-204.
26. Yang H, Ochani M, Li J, Qiang X, Tanovic M, et al. (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A 101: 296-301.
27. Leon LR, Gordon CJ, Helwig BG, Rufolo DM, Blaha MD, (2010) Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model. Am J Physiol Regul Integr Comp Physiol 299: R241-248.
28. Kew M, Bersohn I, Seftel H, Kent G, (1970) Liver damage in heatstroke. Am J Med 49: 192-202.
29. Bianchi L, Ohnacker H, Beck K, Zimmerli-Ning M, (1972) Liver damage in heatstroke and its regression. A biopsy study. Hum Pathol 3: 237-248.
30. Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, et al. (2005) Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol 175: 4834-4838.
31. Malamud N, Haymaker W, Custer R, (1946) Heatstroke: a clinico-pathologic study of 125 fatal cases. Milit Surg 99: 397-449.
32. Makranz C, Heled Y, Moran DS, (2011) Hypothermia following exertional heat stroke treatment. Eur J Appl Physiol 111: 2359-2362.
33. Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, et al. (2005) The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest 115: 1267-1274.
34. Levy RM, Prince JM, Yang R, Mollen KP, Liao H, et al. (2006) Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 291: R970-976.
35. Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, et al. (2005) The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201: 1135-1143.
36. Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, et al. (2005) HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol 288: L958-965.
37. Leon LR, Helwig BG, (2010) Heat stroke: role of the systemic inflammatory response. J Appl Physiol 109: 1980-1988.