Clonidine attenuated early proinflammatory response in T-cell subsets after cardiac surgery

Anesthesia and Analgesia

Volumn 103, Issue 4, 2006, Pages 809-814

  Von Dossow, Vera ^a   Baehr, Nadine ^a   Moshirzadeh, Maryam ^a   Von Heymann, Christian ^a   Braun, Jan P ^a   Hein, Ortrud V ^a   Sander, Michael ^a   Wernecke, Klaus D ^a   Konertz, Wolfgang ^a   Spies, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; CYTOKINE; PLACEBO;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CYTOTOXIC T LYMPHOCYTE; DOUBLE BLIND PROCEDURE; FEMALE; HEART SURGERY; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INTENSIVE CARE UNIT; LYMPHOCYTE FUNCTION; MALE; POSTOPERATIVE INFLAMMATION; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL RISK; SYMPATHETIC TONE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

ADRENERGIC ALPHA-AGONISTS; AGED; ANALGESICS; CLONIDINE; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PROSPECTIVE STUDIES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 33750044882     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000237308.28739.d8     Document Type: Article

References (30)

1. Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg 2002;21:232-44.
2. Doerge H, Schöndube FA, Doerge P, et al. Procalcitonin is a valuable prognostic marker in cardiac surgery but not specific for infection. Thorac Cardiovasc 2003;51:322-6.
3. Sablotzki A, Friedrich I, Mühling J, et al. The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions. Perfusion 2002;17:103-9.
4. Angele MK, Faist E. Clinical review: immunodepression in the surgical patients and increased susceptibility to infection. Crit Care 2002;6:298-305.
5. Hirai S. Systemic inflammatory response syndrome after cardiac surgery under cardiopulmonary bypass. Ann Thorac Cardiovasc Surg 2003;9:365-70.
6. Franke A, Lante W, Feckeldey V, et al. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know? Eur J Cardiothorac Surg 2005;28:569-75.
7. Markewitz A, Lante W, Franke A, et al. Alterations of cell-mediated immunity following cardiac operations: clinical implications and open questions. Shock 2001;16:10-15.
8. Sweeney KJ, Kell MR, Coates C, et al. Serum antigen(s) drive the proinflammatory T cell response in acute pancreatitis. Br J Surg 2003;90:313-9.
9. Kell MR, Kavanaugh EG, Goebel A, et al. Injury primes the immune system for an enhanced lethal T-cell response against bacterial superantigen. Shock 1999;12:139-44.
10. Dorman T, Clarkson K, Rosenfeld B, et al. Effects of clonidine on prolonged sympathetic response. Crit Care Med 1997;25:1147-52.
11. Tank J, Jordan J, Diedrich A, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 2004;43:1042-7.
12. Loick HM, Schmidt C, Van Aken H, et al. High thoracic epidural anesthesia, but not clonidine, attenuates the perioperative stress response via sympatholysis and reduces the release of troponin T in patients undergoing coronary artery bypass grafting. Anesth Analg 1999;88:701-9.
13. Khan MM, Sansoni P, Silverman ED, et al. β-Adrenergic receptors on human suppressor, helper and cytolytic lymphocytes. Biochem Pharmacol 1986;35:1137-42.
14. Gage JR, Fonarow G, Hamilton M, et al. β-Blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory production in patients with chronic heart failure. Neuroimmunomodulation 2004;11:173-80.
15. Swanson MA, Lee WT, Sanders, VM. IFN-γ production by Th1 cells generated from naive CD4 (+) T cells exposed to norepinephrine. J Immunol 2001;166:232-40.
16. Liebmann PM, Hofer D, Felsner P, et al. β-blockade enhances adrenergic immunosuppression in rats via inhibition of melatonin release. J Neuroimmunol 1996;67:137-42.
17. Kox W, Spies C. Cardiac anesthesia. In: Kox WJ, Spies C, eds. Check-up anesthesiology. Berlin: Springer, 2003:446-8.
18. Ramsay MAE, Savege TM. Controlled sedation with alphaloxone/alphadalone. BMJ 1974;2:656-9.
19. Braun JP, Schroeder T, Buehner S, et al. Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass. Acta Anesthesiol Scand 2004;48:697-703.
20. Ely EW, Patricia A. Large scale implementation of a respiratory therapist-driven protocol for ventilator weaning. Am J Respir Crit Care Med 1999;159:439-46.
21. Spies CD, von Dossow V, Eggers V, et al. Altered cell-mediated immunity and increased postoperative infection rate in chronic alcoholic patients. Anesthesiology 2004;100:1088-100.
22. Brunner E, Domhof S, Langer F. Non-parametric analysis of longitudinal data in factorial experiments. New York: Wiley, 2002.
23. Shimaoka M, Hosotsubo K, Sugimoto M, et al. The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation. Anesth Analg 1998;87:1431-5.
24. Ellis JE, Pedlow S. Premedication with clonidine does not attenuate suppression of certain lymphocyte subsets after surgery. Anesth Analg 1998;87:1426-30.
25. Kulka P, Tryba M, Zenz M. Dose-response effects of Intravenous clonidine on stress response during induction of anesthesia in coronary artery bypass grafting. Anesth Analg 1995;80:263-8.
26. Elenkow I, Wilder R, Chrousos GP, Vizi SE. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
27. Sanders VM, Baker RA, Ramer-Quinn DS, et al. Differential expression of the β-2-adrenergic resceptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J Immunol 1997;158:4200-10.
28. + T and B lymphocyte function in vitro and in vivo. Pharmacol Rev 2001;53:487-525.
29. Kim MH, Hahn TH. The effect of pre-treatment on the perioperative proinflammatory cytokines, Cortisol and ACTH responses in patients undergoing total abdominal hysterectomy. Anesth Analg 2000;90:1441-4.
30. Venn RM, Bryant A, Hall GM, Grounds RM. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in postoperative patients needing sedation in the intensive care unit. Br J Anaesth 2001;86:650-6.