Label-free visualization of acetaminophen-induced liver injury by high-speed stimulated Raman scattering spectral microscopy and multivariate image analysis

Pathology International

Volumn 64, Issue 10, 2014, Pages 518-526

  Satoh, Shuya ^a   Otsuka, Yoichi ^a   Ozeki, Yasuyuki ^b   Itoh, Kazuyoshi ^c   Hashiguchi, Akinori ^d   Yamazaki, Ken ^d   Hashimoto, Hiroyuki ^a   Sakamoto, Michiie ^d  

^a Frontier Research Center Canon Incorporation   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Diagnostic imaging; Drug induced liver injury; Principal component analysis; Raman scattering; spectrum analysis

Indexed keywords

FAT DROPLET; GLYCOGEN; HEMOGLOBIN; PARACETAMOL; TRIACYLGLYCEROL; ANALGESIC AGENT;

ACETAMINOPHEN INDUCED LIVER INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL NUCLEUS; CHEMICAL BOND; CONTROLLED STUDY; CYTOPLASM; EOSINOPHIL; ERYTHROCYTE; HISTOPATHOLOGY; IMAGE ANALYSIS; LIGHT ABSORPTION; LIVER CELL; LIVER NECROSIS; LIVER PARENCHYMA; LIVER SINUSOID; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TOXIC HEPATITIS; ANIMAL; C57BL MOUSE; DISEASE MODEL; IMAGE PROCESSING; MICROSCOPY; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY; PRINCIPAL COMPONENT ANALYSIS; SPECTRUM ANALYSIS, RAMAN;

EID: 84924254095     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12206     Document Type: Article

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