Bispolides, novel 20-membered ring macrodiolide antibiotics from Microbispora

Journal of Antibiotics

Volumn 60, Issue 3, 2007, Pages 216-219

  Okujo, Noriyuki ^a   Iinuma, Hironobu ^a   George, Annie ^b   Eim, Khor Siew ^b   Li, Tan Lee ^b   Ting, Ng Szu ^b   Jye, Tan Chin ^b   Hotta, Kunimoto ^a   Hatsu, Masahiro ^a   Fukagawa, Yasuo ^a   Shibahara, Seiji ^a   Numata, Keiichi ^a   Kondo, Shinichi ^a  

^a Nimura Genetic Solutions   (Japan)

^b Nimura Genetic Solutions (M) Sdn Bhd   (Malaysia)

Author keywords

20 menbered ring; Bispolide; Macrodiolide antibiotic; Microbispora sp.; Symmetric cyclic dimmer

Indexed keywords

ANTIBIOTIC AGENT; BISPOLIDE A1; BISPOLIDE A2; BISPOLIDE A3; BISPOLIDE B1; BISPOLIDE B2A; BISPOLIDE B2B; BISPOLIDE B3; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; MACROLIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM; BACTERIUM CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; IN VITRO STUDY; MASS SPECTROMETRY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBISPORA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOIL ANALYSIS; ACTINOMYCETALES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; ISOLATION AND PURIFICATION; LETTER; METABOLISM; MICROBIOLOGICAL EXAMINATION; PENICILLIN RESISTANCE; STAPHYLOCOCCUS AUREUS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBISPORA;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; HUMANS; MACROLIDES; MAGNETIC RESONANCE SPECTROSCOPY; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS;

EID: 34347400027     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.26     Document Type: Article

References (6)

1. Arai M. Azalomycins B and F, two new antibiotics. I. Production and isolation. J Antibiot 13A: 46-50 (1960)
2. Arai M. Azalomycins B and F, two new antibiotics. II. Properties of azalomycins B and F. J Antibiot 13A: 51-56 (1960)
3. Kaiser H, Keller-Schierlein W. 41. Stoffwechselprodukte von Mikroorganismen. 202 Mitteilung Structuraufklarung von Elaiophylin: Spectroskopische Untersuchungen und Abbau. Helv Chim Acta 64: 407-424 (1981)
4. Ritzau M, Heinze S, Fleck WF, Dahse HM, Grafe U. New macrodiolide antibiotics, 11-O-monomethyl- and 11,11′-O- dimethylelaiophylins, from Streptomyces sp. HKI-0113 and HKI-0114. J Nat Prod 61: 1337-1339 (1998)
5. 13C NMR studies of elaiophylin derivatives. Magn Reson Chem 29: 667-670 (1991)
6. Fang A, Wong GK, Demain AL. Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin. J Antibiot 53: 137-143 (2000)