Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 9, 2015, Pages 2835-2840

  Carta, Sonia ^a   Penco, Federica ^b,c   Lavieri, Rosa ^a   Martini, Alberto ^b,c   Dinarello, Charles Anthony ^d,e   Gattorno, Marco ^b   Rubartelli, Anna ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Interleukin 1 family; Primary monocytes; Reactive oxygen species; Redox stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; PURINERGIC P2X RECEPTOR; REACTIVE OXYGEN METABOLITE; CARRIER PROTEIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOINFLAMMATORY DISEASE; CELL STRESS; CINCA SYNDROME; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEARING IMPAIRMENT; MONOCYTE; MOUSE; MUCKLE WELLS SYNDROME; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RASH; REDOX STRESS; ADOLESCENT; ADULT; CHILD; CLINICAL TRIAL; DRUG EFFECTS; FEMALE; GENETICS; HUMAN; INFANT; MALE; METABOLISM; MUTATION; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGICAL STRESS; PRESCHOOL CHILD; SECRETION (PROCESS);

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; CARRIER PROTEINS; CHILD; CHILD, PRESCHOOL; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; CYTOKINES; FEMALE; HUMANS; INFANT; INFLAMMASOMES; MALE; MONOCYTES; MUTATION; OXIDATION-REDUCTION; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; STRESS, PHYSIOLOGICAL;

EID: 84924191070     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424741112     Document Type: Article

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