Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes

Apoptosis

Volumn 20, Issue 4, 2015, Pages 466-480

  Barathan, Muttiah ^a   Gopal, Kaliappan ^a   Mohamed, Rosmawati ^a   Ellegård, Rada ^b   Saeidi, Alireza ^a   Vadivelu, Jamuna ^a   Ansari, Abdul W ^a   Rothan, Hussin A ^a   Ram, M Ravishankar ^a   Zandi, Keivan ^a   Chang, Li Y ^a   Vignesh, Ramachandran ^c   Che, Karlhans F ^d   Kamarulzaman, Adeeba ^a   Velu, Vijayakumar ^e   Larsson, Marie ^b   Kamarul, Tunku ^a   Shankar, Esaki M ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b LINKÖPING UNIVERSITY   (Sweden)

^c YRG CENTRE FOR AIDS RESEARCH AND EDUCATION   (India)

^d KAROLINSKA INSTITUTE   (Sweden)

^e EMORY UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; Hepatitis C; Spontaneous immune exhaustion; TRAIL

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CASPASE 14; CASPASE 3; CELL MARKER; CYCLOOXYGENASE 2; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; MEMBRANE PROTEIN; OSTEOPROTEGERIN; PROGRAMMED DEATH 1 RECEPTOR; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; APOPTOSIS REGULATORY PROTEIN;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL STRESS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE COUNT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION; VIRUS LOAD; ADULT; CHRONIC HEPATITIS C; CYTOLOGY; GENETICS; HEPACIVIRUS; METABOLISM; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; VIROLOGY;

HEPATITIS C VIRUS;

ADULT; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84924185602     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-1084-y     Document Type: Article

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