Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

Gastroenterology

Volumn 146, Issue 2, 2014, Pages 550-561

  Kroy, Daniela C ^a   Ciuffreda, Donatella ^a   Cooperrider, Jennifer H ^a   Tomlinson, Michelle ^a   Hauck, Garrett D ^a   Aneja, Jasneet ^a   Berger, Christoph ^b   Wolski, David ^a   Carrington, Mary ^b,c   Wherry, E John ^d   Chung, Raymond T ^a   Tanabe, Kenneth K ^a   Elias, Nahel ^a   Freeman, Gordon J ^e   De Kruyff, Rosemarie H ^f   Misdraji, Joseph ^a   Kim, Arthur Y ^a   Lauer, Georg M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c SAIC FREDERICK INC   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Costimulation; Immune Regulation; Inflammation; T Cell Exhaustion

Indexed keywords

2B4 PROTEIN; CD160 PROTEIN; LAG 3 PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE INHIBITORY RECEPTOR; T LYMPHOCYTE RECEPTOR; TIM 3 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HLA TYPING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER DISEASE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MIDDLE AGED; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIREMIA; VIRUS LOAD; VIRUS REPLICATION;

CMV; COSTIMULATION; CYTOMEGALOVIRUS; HCV; HEPATITIS C VIRUS; IHL; IMMUNE REGULATION; INFLAMMATION; INTRAHEPATIC LYMPHOCYTE; PBMC; PERIPHERAL BLOOD MONONUCLEAR CELL; T-CELL EXHAUSTION;

ANTIGENS, CD; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, IMMUNOLOGIC; VIRUS REPLICATION;

EID: 84892727073     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.022     Document Type: Article

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