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Volumn 48, Issue 5, 2013, Pages 660-670

Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection

Author keywords

Dendritic cell; Hepatitis C virus; Indoleamine 2,3 dioxygenase; Regulatory T cell

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; KYNURENINE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84878115181     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0667-z     Document Type: Article
Times cited : (39)

References (37)
  • 1
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • 11439948 10.1056/NEJM200107053450107 1:STN:280:DC%2BD3MzosFGrug%3D%3D
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med. 2001;345:41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 2
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • 12407575 10.1002/hep.1840360706
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology. 2002;36:S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 3
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • 9521319 10.1038/32588 1:CAS:528:DyaK1cXitFWrsr8%3D
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-52.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 4
    • 0042971652 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells
    • 12615891 10.1146/annurev.immunol.21.120601.141040 1:CAS:528: DC%2BD3sXjtF2is7g%3D
    • Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685-711.
    • (2003) Annu Rev Immunol , vol.21 , pp. 685-711
    • Steinman, R.M.1    Hawiger, D.2    Nussenzweig, M.C.3
  • 5
    • 0033136306 scopus 로고    scopus 로고
    • Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals
    • 10228041 1:CAS:528:DyaK1MXislGnsbw%3D
    • Kanto T, Hayashi N, Takehara T, Tatsumi T, Kuzushita N, Ito A, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol. 1999;162:5584-91.
    • (1999) J Immunol , vol.162 , pp. 5584-5591
    • Kanto, T.1    Hayashi, N.2    Takehara, T.3    Tatsumi, T.4    Kuzushita, N.5    Ito, A.6
  • 6
    • 9444280924 scopus 로고    scopus 로고
    • Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection
    • 15529255 10.1086/425425
    • Kanto T, Inoue M, Miyatake H, Sato A, Sakakibara M, Yakushijin T, et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis. 2004;190:1919-26.
    • (2004) J Infect Dis , vol.190 , pp. 1919-1926
    • Kanto, T.1    Inoue, M.2    Miyatake, H.3    Sato, A.4    Sakakibara, M.5    Yakushijin, T.6
  • 7
    • 0035121503 scopus 로고    scopus 로고
    • Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
    • 11159892 10.1053/gast.2001.21212 1:CAS:528:DC%2BD3MXhtlKltb0%3D
    • Bain C, Fatmi A, Zoulim F, Zarski JP, Trepo C, Inchauspe G. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology. 2001;120:512-24.
    • (2001) Gastroenterology , vol.120 , pp. 512-524
    • Bain, C.1    Fatmi, A.2    Zoulim, F.3    Zarski, J.P.4    Trepo, C.5    Inchauspe, G.6
  • 8
    • 4344713084 scopus 로고    scopus 로고
    • Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C
    • 15320906 10.1111/j.1365-2249.2004.02550.x 1:CAS:528:DC%2BD2cXnvFKjtbk%3D
    • Murakami H, Akbar SM, Matsui H, Horiike N, Onji M. Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C. Clin Exp Immunol. 2004;137:559-65.
    • (2004) Clin Exp Immunol , vol.137 , pp. 559-565
    • Murakami, H.1    Akbar, S.M.2    Matsui, H.3    Horiike, N.4    Onji, M.5
  • 9
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • 15032588 10.1146/annurev.immunol.21.120601.141122 1:CAS:528: DC%2BD2cXktlOgsLo%3D
    • Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531-62.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 10
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • 15486925 10.1002/hep.20454 1:CAS:528:DC%2BD2cXhtVCgt73P
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004;40:1062-71.
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6
  • 11
    • 70449411040 scopus 로고    scopus 로고
    • Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis
    • 19486278 10.1111/j.1365-2893.2009.01131.x 1:STN:280: DC%2BD1MjktVGitw%3D%3D
    • Itose I, Kanto T, Kakita N, Takebe S, Inoue M, Higashitani K, et al. Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis. J Viral Hepat. 2009;16:844-52.
    • (2009) J Viral Hepat , vol.16 , pp. 844-852
    • Itose, I.1    Kanto, T.2    Kakita, N.3    Takebe, S.4    Inoue, M.5    Higashitani, K.6
  • 12
    • 0022354604 scopus 로고
    • Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme
    • 3877502 1:CAS:528:DyaL2MXmtFWrurs%3D
    • Yamazaki F, Kuroiwa T, Takikawa O, Kido R. Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme. Biochem J. 1985;230:635-8.
    • (1985) Biochem J , vol.230 , pp. 635-638
    • Yamazaki, F.1    Kuroiwa, T.2    Takikawa, O.3    Kido, R.4
  • 13
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • 15459668 10.1038/nri1457 1:CAS:528:DC%2BD2cXotVSlsLg%3D
    • Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 2004;4:762-74.
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 14
    • 0025944659 scopus 로고
    • Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism
    • 1907934 1:CAS:528:DyaK3MXltlentbs%3D
    • Taylor MW, Feng GS. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 1991;5:2516-22.
    • (1991) FASEB J , vol.5 , pp. 2516-2522
    • Taylor, M.W.1    Feng, G.S.2
  • 15
    • 34249741135 scopus 로고    scopus 로고
    • On watching the watchers: IDO and type I/II IFN
    • 17393386 10.1002/eji.200737184 1:CAS:528:DC%2BD2sXkvVSgs78%3D
    • Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol. 2007;37:876-9.
    • (2007) Eur J Immunol , vol.37 , pp. 876-879
    • Puccetti, P.1
  • 16
    • 27144476792 scopus 로고    scopus 로고
    • A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation
    • 15947091 10.1182/blood-2005-03-0979 1:CAS:528:DC%2BD2MXhtVKqt7zI
    • Braun D, Longman RS, Albert ML. A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood. 2005;106:2375-81.
    • (2005) Blood , vol.106 , pp. 2375-2381
    • Braun, D.1    Longman, R.S.2    Albert, M.L.3
  • 17
    • 34147115208 scopus 로고    scopus 로고
    • HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    • 17158233 10.1182/blood-2006-07-034785 1:CAS:528:DC%2BD2sXksFWiu78%3D
    • Boasso A, Herbeuval JP, Hardy AW, Anderson SA, Dolan MJ, Fuchs D, et al. HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. Blood. 2007;109:3351-9.
    • (2007) Blood , vol.109 , pp. 3351-3359
    • Boasso, A.1    Herbeuval, J.P.2    Hardy, A.W.3    Anderson, S.A.4    Dolan, M.J.5    Fuchs, D.6
  • 18
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • 9712583 10.1126/science.281.5380.1191 1:CAS:528:DyaK1cXls1Cqu7c%3D
    • Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191-3.
    • (1998) Science , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3    Bondarev, I.4    Conway, S.J.5    Marshall, B.6
  • 19
    • 33846278407 scopus 로고    scopus 로고
    • The role of indoleamine 2,3-dioxygenase in transplantation
    • 17239019 10.1111/j.1432-2277.2006.00370.x 1:CAS:528:DC%2BD2sXis1SjsLg%3D
    • Hainz U, Jurgens B, Heitger A. The role of indoleamine 2,3-dioxygenase in transplantation. Transpl Int. 2007;20:118-27.
    • (2007) Transpl Int , vol.20 , pp. 118-127
    • Hainz, U.1    Jurgens, B.2    Heitger, A.3
  • 20
    • 27644587079 scopus 로고    scopus 로고
    • Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite
    • 16272121 10.1126/science.1117634 1:CAS:528:DC%2BD2MXhtFKksLbJ
    • Platten M, Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science. 2005;310:850-5.
    • (2005) Science , vol.310 , pp. 850-855
    • Platten, M.1    Ho, P.P.2    Youssef, S.3    Fontoura, P.4    Garren, H.5    Hur, E.M.6
  • 21
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • 14502282 10.1038/nm934 1:CAS:528:DC%2BD3sXns1Clu7c%3D
    • Uyttenhove C, Pilotte L, Theate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med. 2003;9:1269-74.
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3    Stroobant, V.4    Colau, D.5    Parmentier, N.6
  • 22
    • 18544364477 scopus 로고    scopus 로고
    • Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    • 12228717 10.1126/science.1073514 1:CAS:528:DC%2BD38Xnt1Shsro%3D
    • Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science. 2002;297:1867-70.
    • (2002) Science , vol.297 , pp. 1867-1870
    • Munn, D.H.1    Sharma, M.D.2    Lee, J.R.3    Jhaver, K.G.4    Johnson, T.S.5    Keskin, D.B.6
  • 23
    • 0037136266 scopus 로고    scopus 로고
    • Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: Mediation of suppression by tryptophan metabolites
    • 12186837 10.1084/jem.20020052 1:CAS:528:DC%2BD38XmsV2htLg%3D
    • Terness P, Bauer TM, Rose L, Dufter C, Watzlik A, Simon H, et al. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med. 2002;196:447-57.
    • (2002) J Exp Med , vol.196 , pp. 447-457
    • Terness, P.1    Bauer, T.M.2    Rose, L.3    Dufter, C.4    Watzlik, A.5    Simon, H.6
  • 24
    • 54049151564 scopus 로고    scopus 로고
    • The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    • 18832696 1:CAS:528:DC%2BD1cXhtF2hs7fN
    • Chen W, Liang X, Peterson AJ, Munn DH, Blazar BR. The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol. 2008;181:5396-404.
    • (2008) J Immunol , vol.181 , pp. 5396-5404
    • Chen, W.1    Liang, X.2    Peterson, A.J.3    Munn, D.H.4    Blazar, B.R.5
  • 25
    • 70350433798 scopus 로고    scopus 로고
    • Interferon-gamma-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells
    • 19625705 10.1182/blood-2008-12-195073
    • Jurgens B, Hainz U, Fuchs D, Felzmann T, Heitger A. Interferon-gamma- triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells. Blood. 2009;114:3235-43.
    • (2009) Blood , vol.114 , pp. 3235-3243
    • Jurgens, B.1    Hainz, U.2    Fuchs, D.3    Felzmann, T.4    Heitger, A.5
  • 26
    • 33947434850 scopus 로고    scopus 로고
    • Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection
    • 17229698 10.1128/JVI.02248-06 1:CAS:528:DC%2BD2sXjslWqtr4%3D
    • Larrea E, Riezu-Boj JI, Gil-Guerrero L, Casares N, Aldabe R, Sarobe P, et al. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol. 2007;81:3662-6.
    • (2007) J Virol , vol.81 , pp. 3662-3666
    • Larrea, E.1    Riezu-Boj, J.I.2    Gil-Guerrero, L.3    Casares, N.4    Aldabe, R.5    Sarobe, P.6
  • 27
    • 33644631594 scopus 로고    scopus 로고
    • Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection
    • 16458588 10.1016/j.hepres.2005.12.010 1:CAS:528:DC%2BD28XitVKnsLg%3D
    • Yakushijin T, Kanto T, Inoue M, Oze T, Miyazaki M, Itose I, et al. Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection. Hepatol Res. 2006;34:156-62.
    • (2006) Hepatol Res , vol.34 , pp. 156-162
    • Yakushijin, T.1    Kanto, T.2    Inoue, M.3    Oze, T.4    Miyazaki, M.5    Itose, I.6
  • 28
    • 0023013615 scopus 로고
    • Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase
    • 2419335 1:CAS:528:DyaL28XitVCnsrs%3D
    • Takikawa O, Yoshida R, Kido R, Hayaishi O. Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem. 1986;261:3648-53.
    • (1986) J Biol Chem , vol.261 , pp. 3648-3653
    • Takikawa, O.1    Yoshida, R.2    Kido, R.3    Hayaishi, O.4
  • 29
    • 75749113671 scopus 로고    scopus 로고
    • Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
    • 19487045 10.1016/j.lungcan.2009.05.001
    • Suzuki Y, Suda T, Furuhashi K, Suzuki M, Fujie M, Hahimoto D, et al. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. Lung Cancer. 2010;67:361-5.
    • (2010) Lung Cancer , vol.67 , pp. 361-365
    • Suzuki, Y.1    Suda, T.2    Furuhashi, K.3    Suzuki, M.4    Fujie, M.5    Hahimoto, D.6
  • 30
    • 35348861379 scopus 로고    scopus 로고
    • Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): Mechanism of induction and role in antiviral response
    • 17626075 10.1128/JVI.00792-07 1:CAS:528:DC%2BD2sXhtVeht7bO
    • Suh HS, Zhao ML, Rivieccio M, Choi S, Connolly E, Zhao Y, et al. Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. J Virol. 2007;81:9838-50.
    • (2007) J Virol , vol.81 , pp. 9838-9850
    • Suh, H.S.1    Zhao, M.L.2    Rivieccio, M.3    Choi, S.4    Connolly, E.5    Zhao, Y.6
  • 31
    • 76249093444 scopus 로고    scopus 로고
    • Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance
    • 19933867 10.4049/jimmunol.0901004 1:CAS:528:DC%2BD1MXhsFCkt7rF
    • Godin-Ethier J, Pelletier S, Hanafi LA, Gannon PO, Forget MA, Routy JP, et al. Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. J Immunol. 2009;183:7752-60.
    • (2009) J Immunol , vol.183 , pp. 7752-7760
    • Godin-Ethier, J.1    Pelletier, S.2    Hanafi, L.A.3    Gannon, P.O.4    Forget, M.A.5    Routy, J.P.6
  • 32
    • 33947532866 scopus 로고    scopus 로고
    • Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
    • 17367785 10.1016/j.febslet.2007.02.073 1:CAS:528:DC%2BD2sXjsVWnsb8%3D
    • Jung ID, Lee CM, Jeong YI, Lee JS, Park WS, Han J, et al. Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells. FEBS Lett. 2007;581:1449-56.
    • (2007) FEBS Lett , vol.581 , pp. 1449-1456
    • Jung, I.D.1    Lee, C.M.2    Jeong, Y.I.3    Lee, J.S.4    Park, W.S.5    Han, J.6
  • 33
    • 33745654304 scopus 로고    scopus 로고
    • The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: Involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines
    • 16672265 10.1093/jb/mvj072 1:CAS:528:DC%2BD28XlsVGku7g%3D
    • Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H, et al. The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J Biochem. 2006;139:655-62.
    • (2006) J Biochem , vol.139 , pp. 655-662
    • Fujigaki, H.1    Saito, K.2    Fujigaki, S.3    Takemura, M.4    Sudo, K.5    Ishiguro, H.6
  • 34
    • 0034850590 scopus 로고    scopus 로고
    • Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism
    • 11477543 10.1002/1521-4141(200108)31:8<2313: AID-IMMU2313>3.0.CO;2- S 1:CAS:528:DC%2BD3MXmt1ensrk%3D
    • Fujigaki S, Saito K, Sekikawa K, Tone S, Takikawa O, Fujii H, et al. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur J Immunol. 2001;31:2313-8.
    • (2001) Eur J Immunol , vol.31 , pp. 2313-2318
    • Fujigaki, S.1    Saito, K.2    Sekikawa, K.3    Tone, S.4    Takikawa, O.5    Fujii, H.6
  • 35
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • 15894280 10.1016/j.immuni.2005.03.013 1:CAS:528:DC%2BD2MXkslOqtr8%3D
    • Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity. 2005;22:633-42.
    • (2005) Immunity , vol.22 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6
  • 36
    • 67749091321 scopus 로고    scopus 로고
    • Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    • 19567830 10.1073/pnas.0903919106 1:CAS:528:DC%2BD1MXps1anurc%3D
    • Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci USA. 2009;106:12055-60.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12055-12060
    • Cobbold, S.P.1    Adams, E.2    Farquhar, C.A.3    Nolan, K.F.4    Howie, D.5    Lui, K.O.6
  • 37
    • 38449114545 scopus 로고    scopus 로고
    • Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells
    • 17911604 1:CAS:528:DC%2BD2sXhtFWitrjN
    • Li R, Perez N, Karumuthil-Melethil S, Prabhakar BS, Holterman MJ, Vasu C. Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells. J Immunol. 2007;179:5191-203.
    • (2007) J Immunol , vol.179 , pp. 5191-5203
    • Li, R.1    Perez, N.2    Karumuthil-Melethil, S.3    Prabhakar, B.S.4    Holterman, M.J.5    Vasu, C.6


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