Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

Journal of Cell Biology

Volumn 155, Issue 3, 2001, Pages 505-510

  Wu, Chuanyue ^a   Dedhar, Shoukat ^b,c,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Cell adhesion; Cytoskeleton; Integrin linked kinase; Integrins; Signal transduction

Indexed keywords

ACTIN; INTEGRIN; INTEGRIN LINKED KINASE; UNCLASSIFIED DRUG; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; ACTIN FILAMENT; ANIMAL; CYTOSKELETON; METABOLISM; PHYSIOLOGY;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMANS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84924089603     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

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7. Integrin-linked kinase expression increases with prostate tumor grade
8. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys
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10. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans
11. The roles of integrin-linked kinase in the regulation of myogenic differentiation
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14. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
15. Integrin linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
16. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
17. The MMAC tumor suppressor phosphatase inhibits phospholipase C and integrin linked kinase activity
18. Phosphorylation of the betal integrin subunit cytoplasmic domain: Toward an understanding of function and mechanism
19. Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion
20. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions
21. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily
22. Inhibition of integrin linked kinase (ILK) suppresses activation of PKB/Akt and induces cell cycle arrest and apoptosis in PTEN-null prostate cancer cells
23. Regulation of protein kinase B/Akt-serine-473 phosphorylation by integrin linked kinase (ILK): Critical roles for kinase activity and amino acids arginine-211 and serine-343
24. Tumor suppressor PTEN inhibits beta-catenin nuclear localization and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
25. Overexpression of integrin linked kinase initiates a mesenchymal transformation of mammary epithelial cells
26. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin suppressor, snail in APC -/- human colon carcinoma cells
27. The integrin linked kinase induces an invasive phenotype via Ap-1 transcription factor dependent upregulation of matrix metalloproteinase (MMP-9)
28. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase signaling pathways
29. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
30. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
31. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with integrin linked kinase ankyrin repeat domain
32. Mammary epithelial specific expression of the integrin linked kinase (ILK) in transgenic mice results in the induction of hyperplasias and tumors
33. Integrin-linked kinase and PINCH: Partners in regulation of cell-extracellular matrix interaction and signal transduction
34. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
35. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction
36. Molecular diversity of cell-matrix adhesions
37. Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane