To the editor: Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis

Blood

Volumn 123, Issue 4, 2014, Pages 597-600

  Douda, David N ^a,b   Yip, Lily ^a,b   Khan, Meraj A ^a   Grasemann, Hartmut ^b,c   Palaniyar, Nades ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

APOPTOSIS; AUTOPHAGY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; LETTER; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ARTICLE; CELL NUCLEUS; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INFLAMMATION; METABOLISM; PATHOLOGY;

APOPTOSIS; CELL NUCLEUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOBLOTTING; INFLAMMATION; MICROSCOPY, FLUORESCENCE; NADP; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84897019018     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-09-526707     Document Type: Letter

References (10)

1. Cheng OZ, Palaniyar N. NET balancing: a problem in inflammatory lung diseases. Front Immunol. 2013;4:1.
2. Sangaletti S, Tripodo C, Chiodoni C, et al. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood. 2012; 120(15):3007-3018.
3. Thomas GM, Carbo C, Curtis BR, et al. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012;119(26):6335-6343.
4. Chen K, Nishi H, Travers R, et al. Endocytosis of soluble immune complexes leads to their clearance by FcgRIIIB but induces neutrophil extracellular traps via FcgRIIA in vivo. Blood. 2012;120(22):4421-4431.
5. Douda DN, Jackson R, Grasemann H, Palaniyar N. Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping. J Immunol. 2011;187(4):1856-1865.
6. Brinkmann V, Zychlinsky A. Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol. 2012;198(5):773-783.
7. Yousefi S, Simon D, Simon HU. Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease. Curr Opin Immunol. 2012;24(6): 736-739.
8. Remijsen Q, Vanden Berghe T, Wirawan E, et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 2011; 21(2):290-304.
9. McInturff AM, Cody MJ, Elliott EA, et al. Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxiainducible factor 1 a. Blood. 2012;120(15):3118-3125.
10. Rane MJ, Klein JB. Regulation of neutrophil apoptosis by modulation of PKB/Akt activation. Front Biosci (Landmark Ed). 2009;14:2400-2412.