메뉴 건너뛰기




Volumn 64, Issue 1, 2015, Pages 1-4

20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

EID: 84924014641     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.10.023     Document Type: Editorial
Times cited : (61)

References (41)
  • 1
    • 0029686334 scopus 로고    scopus 로고
    • Obese, a new mutation in the house mouse
    • [Epub 1996/01/01, PubMed PMID: 8787944]
    • A.M. Ingalls, M.M. Dickie, and G.D. Snell Obese, a new mutation in the house mouse Obes Res 4 1 1996 101 [Epub 1996/01/01, PubMed PMID: 8787944]
    • (1996) Obes Res , vol.4 , Issue.1 , pp. 101
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • [Epub 1994/12/01, PubMed PMID: 7984236]
    • Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 6505 1994 425 432 10.1038/372425a0 [Epub 1994/12/01, PubMed PMID: 7984236]
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 3
    • 0031570346 scopus 로고    scopus 로고
    • The molecular basis of the obese mutation in ob2j mice
    • [Epub 1997/05/15, PubMed PMID: 9177786]
    • B.C. Moon, and J.M. Friedman The molecular basis of the obese mutation in ob2j mice Genomics 42 1 1997 152 156 10.1006/geno.1997.4701 [Epub 1997/05/15, PubMed PMID: 9177786]
    • (1997) Genomics , vol.42 , Issue.1 , pp. 152-156
    • Moon, B.C.1    Friedman, J.M.2
  • 4
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • [Epub 1978/03/01, PubMed PMID: 350680]
    • D.L. Coleman Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice Diabetologia 14 3 1978 141 148 [Epub 1978/03/01, PubMed PMID: 350680]
    • (1978) Diabetologia , vol.14 , Issue.3 , pp. 141-148
    • Coleman, D.L.1
  • 5
    • 0014682035 scopus 로고
    • Regulation of energy balance
    • [Epub 1969/05/17, PubMed PMID: 5768271]
    • G.R. Hervey Regulation of energy balance Nature 222 5194 1969 629 631 [Epub 1969/05/17, PubMed PMID: 5768271]
    • (1969) Nature , vol.222 , Issue.5194 , pp. 629-631
    • Hervey, G.R.1
  • 6
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • [Epub 1998/10/31, PubMed PMID: 9796811]
    • J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 6704 1998 763 770 10.1038/27376 [Epub 1998/10/31, PubMed PMID: 9796811]
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 8
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • [Epub 1996/02/15, PubMed PMID: 8628397]
    • G.H. Lee, R. Proenca, J.M. Montez, K.M. Carroll, J.G. Darvishzadeh, J.I. Lee, and J.M. Friedman Abnormal splicing of the leptin receptor in diabetic mice Nature 379 6566 1996 632 635 10.1038/379632a0 [Epub 1996/02/15, PubMed PMID: 8628397]
    • (1996) Nature , vol.379 , Issue.6566 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3    Carroll, K.M.4    Darvishzadeh, J.G.5    Lee, J.I.6    Friedman, J.M.7
  • 10
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • [Epub 1995/11/01, PubMed PMID: 7584987]
    • M. Maffei, J. Halaas, E. Ravussin, R.E. Pratley, G.H. Lee, Y. Zhang, H. Fei, S. Kim, R. Lallone, and S. Ranganathan Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nat Med 1 11 1995 1155 1161 [Epub 1995/11/01, PubMed PMID: 7584987]
    • (1995) Nat Med , vol.1 , Issue.11 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5    Zhang, Y.6    Fei, H.7    Kim, S.8    Lallone, R.9    Ranganathan, S.10
  • 11
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • [Epub 2003/05/03, PubMed PMID: 12727933; PubMed Central PMCID: PMCPMC154448]
    • J.L. Chan, K. Heist, A.M. DePaoli, J.D. Veldhuis, and C.S. Mantzoros The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men J Clin Invest 111 9 2003 1409 1421 10.1172/jci17490 [Epub 2003/05/03, PubMed PMID: 12727933; PubMed Central PMCID: PMCPMC154448]
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    Depaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 12
    • 0026326384 scopus 로고
    • Obesity, a disorder of nutrient partitioning: The Mona Lisa hypothesis
    • [Epub 1991/08/01. PubMed PMID: 1861165]
    • G.A. Bray Obesity, a disorder of nutrient partitioning: the Mona Lisa hypothesis J Nutr 121 8 1991 1146 1162 [Epub 1991/08/01. PubMed PMID: 1861165]
    • (1991) J Nutr , vol.121 , Issue.8 , pp. 1146-1162
    • Bray, G.A.1
  • 13
    • 84924041624 scopus 로고    scopus 로고
    • Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders
    • O.M. Farr, M.A. Tsoukas, and C.S. Mantzoros Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders Metabolism 2014 10.1016/j.metabol.2014.07.004 [Epub 2014/08/06, PubMed PMID: 25092133]
    • (2014) Metabolism
    • Farr, O.M.1    Tsoukas, M.A.2    Mantzoros, C.S.3
  • 14
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
    • [Epub 1994/10/27, PubMed PMID: 7935841]
    • D. Lu, D. Willard, I.R. Patel, S. Kadwell, L. Overton, T. Kost, M. Luther, W. Chen, R.P. Woychik, and W.O. Wilkison Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor Nature 371 6500 1994 799 802 10.1038/371799a0 [Epub 1994/10/27, PubMed PMID: 7935841]
    • (1994) Nature , vol.371 , Issue.6500 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3    Kadwell, S.4    Overton, L.5    Kost, T.6    Luther, M.7    Chen, W.8    Woychik, R.P.9    Wilkison, W.O.10
  • 15
    • 84916210495 scopus 로고    scopus 로고
    • Leptin: A hormone linking activation of neuroendocrine axes with neuropathology
    • [Epub 2014/10/08, PubMed PMID: 25290346]
    • M.R. Stieg, C. Sievers, O. Farr, G.K. Stalla, and C.S. Mantzoros Leptin: a hormone linking activation of neuroendocrine axes with neuropathology Psychoneuroendocrinology 51C 2014 47 57 10.1016/j.psyneuen.2014.09.004 [Epub 2014/10/08, PubMed PMID: 25290346]
    • (2014) Psychoneuroendocrinology , vol.51 C , pp. 47-57
    • Stieg, M.R.1    Sievers, C.2    Farr, O.3    Stalla, G.K.4    Mantzoros, C.S.5
  • 16
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • [Epub 1997/10/06, PubMed PMID: 9311920]
    • M.M. Ollmann, B.D. Wilson, Y.K. Yang, J.A. Kerns, Y. Chen, I. Gantz, and G.S. Barsh Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 278 5335 1997 135 138 [Epub 1997/10/06, PubMed PMID: 9311920]
    • (1997) Science , vol.278 , Issue.5335 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 18
    • 0031012588 scopus 로고    scopus 로고
    • The alphabet of weight control
    • [Epub 1997/01/09, PubMed PMID: 8990109]
    • J.M. Friedman The alphabet of weight control Nature 385 6612 1997 119 120 10.1038/385119a0 [Epub 1997/01/09, PubMed PMID: 8990109]
    • (1997) Nature , vol.385 , Issue.6612 , pp. 119-120
    • Friedman, J.M.1
  • 19
    • 31944437527 scopus 로고    scopus 로고
    • Leptin: A potential novel antidepressant
    • [Epub 2006/01/21, PubMed PMID: 16423896; PubMed Central PMCID: PMCPMC1360555]
    • X.Y. Lu, C.S. Kim, A. Frazer, and W. Zhang Leptin: a potential novel antidepressant Proc Natl Acad Sci U S A 103 5 2006 1593 1598 10.1073/pnas.0508901103 [Epub 2006/01/21, PubMed PMID: 16423896; PubMed Central PMCID: PMCPMC1360555]
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.5 , pp. 1593-1598
    • Lu, X.Y.1    Kim, C.S.2    Frazer, A.3    Zhang, W.4
  • 21
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • [Epub 1998/03/21, PubMed PMID: 9500540]
    • A. Strobel, T. Issad, L. Camoin, M. Ozata, and A.D. Strosberg A leptin missense mutation associated with hypogonadism and morbid obesity Nat Genet 18 3 1998 213 215 10.1038/ng0398-213 [Epub 1998/03/21, PubMed PMID: 9500540]
    • (1998) Nat Genet , vol.18 , Issue.3 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 24
    • 0031766810 scopus 로고    scopus 로고
    • Leptin in relation to resumption of menses in women with anorexia nervosa
    • L. Audi, C.S. Mantzoros, and A. Vidal-Puig Leptin in relation to resumption of menses in women with anorexia nervosa Mol Psychiatry 3 6 1998 544 547
    • (1998) Mol Psychiatry , vol.3 , Issue.6 , pp. 544-547
    • Audi, L.1    Mantzoros, C.S.2    Vidal-Puig, A.3
  • 25
    • 84879882621 scopus 로고    scopus 로고
    • Leptin at the intersection of neuroendocrinology and metabolism: Current evidence and therapeutic perspectives
    • [Epub 2013/06/19, S1550-4131(13)00200-3 [pii]. PubMed PMID: 23770129]
    • M. Dalamaga, S.H. Chou, K. Shields, P. Papageorgiou, S.A. Polyzos, and C.S. Mantzoros Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives Cell Metab 18 1 2013 29 42 10.1016/j.cmet.2013.05.010 [Epub 2013/06/19, S1550-4131(13)00200-3 [pii]. PubMed PMID: 23770129]
    • (2013) Cell Metab , vol.18 , Issue.1 , pp. 29-42
    • Dalamaga, M.1    Chou, S.H.2    Shields, K.3    Papageorgiou, P.4    Polyzos, S.A.5    Mantzoros, C.S.6
  • 26
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • R.S. Ahima, D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J.S. Flier Role of leptin in the neuroendocrine response to fasting Nature 382 6588 1996 250 252 10.1038/382250a0 [Epub 1996/07/18, PubMed PMID: 8717038]
    • (1996) Nature , vol.382 , Issue.6588 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3    Qu, D.4    Lowell, B.5    Maratos-Flier, E.6    Flier, J.S.7
  • 27
    • 21844471790 scopus 로고    scopus 로고
    • Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    • [Epub 2005/07/05, PubMed PMID: 15993236]
    • J.L. Chan, and C.S. Mantzoros Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa Lancet 366 9479 2005 74 85 10.1016/s0140-6736(05)66830-4 [Epub 2005/07/05, PubMed PMID: 15993236]
    • (2005) Lancet , vol.366 , Issue.9479 , pp. 74-85
    • Chan, J.L.1    Mantzoros, C.S.2
  • 28
    • 4344690525 scopus 로고    scopus 로고
    • Recombinant human leptin in women with hypothalamic amenorrhea
    • [Epub 2004/09/03, [pii]. PubMed PMID: 15342807]
    • C.K. Welt, J.L. Chan, J. Bullen, R. Murphy, P. Smith, A.M. DePaoli, A. Karalis, and C.S. Mantzoros Recombinant human leptin in women with hypothalamic amenorrhea N Engl J Med 351 10 2004 987 997 10.1056/NEJMoa04038351/10/987 [Epub 2004/09/03, [pii]. PubMed PMID: 15342807]
    • (2004) N Engl J Med , vol.351 , Issue.10 , pp. 987-997
    • Welt, C.K.1    Chan, J.L.2    Bullen, J.3    Murphy, R.4    Smith, P.5    Depaoli, A.M.6    Karalis, A.7    Mantzoros, C.S.8
  • 29
    • 84874480871 scopus 로고    scopus 로고
    • Selective capacity of metreleptin administration to reconstitute CD4 + T-cell number in females with acquired hypoleptinemia
    • [Epub 2013/02/06, PubMed PMID: 23382191; PubMed Central PMCID: PMCPMC3587204]
    • G. Matarese, C. La Rocca, H.S. Moon, J.Y. Huh, M.T. Brinkoetter, S. Chou, F. Perna, D. Greco, H.P. Kilim, C. Gao, K. Arampatzi, Z. Wang, and C.S. Mantzoros Selective capacity of metreleptin administration to reconstitute CD4 + T-cell number in females with acquired hypoleptinemia Proc Natl Acad Sci U S A 110 9 2013 E818 E827 10.1073/pnas.1214554110 [Epub 2013/02/06, PubMed PMID: 23382191; PubMed Central PMCID: PMCPMC3587204]
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.9 , pp. E818-E827
    • Matarese, G.1    La Rocca, C.2    Moon, H.S.3    Huh, J.Y.4    Brinkoetter, M.T.5    Chou, S.6    Perna, F.7    Greco, D.8    Kilim, H.P.9    Gao, C.10    Arampatzi, K.11    Wang, Z.12    Mantzoros, C.S.13
  • 30
    • 80051800457 scopus 로고    scopus 로고
    • Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women
    • [Epub 2011/07/12, S0026-0495(11)00156-9 [pii]. PubMed PMID: 21741057]
    • E. Sienkiewicz, F. Magkos, K.N. Aronis, M. Brinkoetter, J.P. Chamberland, S. Chou, K.M. Arampatzi, C. Gao, A. Koniaris, and C.S. Mantzoros Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women Metabolism 60 9 2011 1211 1221 10.1016/j.metabol.2011.05.016 [Epub 2011/07/12, S0026-0495(11)00156-9 [pii]. PubMed PMID: 21741057]
    • (2011) Metabolism , vol.60 , Issue.9 , pp. 1211-1221
    • Sienkiewicz, E.1    Magkos, F.2    Aronis, K.N.3    Brinkoetter, M.4    Chamberland, J.P.5    Chou, S.6    Arampatzi, K.M.7    Gao, C.8    Koniaris, A.9    Mantzoros, C.S.10
  • 31
    • 84878656502 scopus 로고    scopus 로고
    • Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals
    • [Epub 2013/03/12, PubMed PMID: 23475416; PubMed Central PMCID: PMCPMC3660716]
    • H.S. Moon, M. Dalamaga, S.Y. Kim, S.A. Polyzos, O.P. Hamnvik, F. Magkos, J. Paruthi, and C.S. Mantzoros Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals Endocr Rev 34 3 2013 377 412 10.1210/er.2012-1053 [Epub 2013/03/12, PubMed PMID: 23475416; PubMed Central PMCID: PMCPMC3660716]
    • (2013) Endocr Rev , vol.34 , Issue.3 , pp. 377-412
    • Moon, H.S.1    Dalamaga, M.2    Kim, S.Y.3    Polyzos, S.A.4    Hamnvik, O.P.5    Magkos, F.6    Paruthi, J.7    Mantzoros, C.S.8
  • 32
    • 84921953911 scopus 로고    scopus 로고
    • Leptin in congenital and hiv-associated lipodystrophy
    • M.A. Tsoukas, O.M. Farr, and C.S. Mantzoros Leptin in congenital and hiv-associated lipodystrophy Metabolism 2014 10.1016/j.metabol.2014.07.017 [Epub 2014/10/01, PubMed PMID: 25267014]
    • (2014) Metabolism
    • Tsoukas, M.A.1    Farr, O.M.2    Mantzoros, C.S.3
  • 33
    • 79952185204 scopus 로고    scopus 로고
    • Lipodystrophy: Pathophysiology and advances in treatment
    • C.G. Fiorenza, S.H. Chou, and C.S. Mantzoros Lipodystrophy: pathophysiology and advances in treatment Nat Rev Endocrinol 7 3 2011 137 150 10.1038/nrendo.2010.199 Epub 2010/11/17, PubMed PMID: 21079616; PubMed Central PMCID: PMCPmc3150735
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.3 , pp. 137-150
    • Fiorenza, C.G.1    Chou, S.H.2    Mantzoros, C.S.3
  • 34
    • 0030737953 scopus 로고    scopus 로고
    • Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
    • [Epub 1997/08/05. PubMed PMID: 9238071; PubMed Central PMCID: PMCPMC23177]
    • J.L. Halaas, C. Boozer, J. Blair-West, N. Fidahusein, D.A. Denton, and J.M. Friedman Physiological response to long-term peripheral and central leptin infusion in lean and obese mice Proc Natl Acad Sci U S A 94 16 1997 8878 8883 [Epub 1997/08/05. PubMed PMID: 9238071; PubMed Central PMCID: PMCPMC23177]
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.16 , pp. 8878-8883
    • Halaas, J.L.1    Boozer, C.2    Blair-West, J.3    Fidahusein, N.4    Denton, D.A.5    Friedman, J.M.6
  • 36
    • 84916620242 scopus 로고    scopus 로고
    • Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin sensitive subjects without altering brain structure
    • [Epub 2014/10/04, PubMed PMID: 25279500]
    • O.M. Farr, C. Fiorenza, P. Papageorgiou, M. Brinkoetter, F. Ziemke, B.B. Koo, R. Rojas, and C.S. Mantzoros Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin sensitive subjects without altering brain structure J Clin Endocrinol Metab 2014 jc20142774 10.1210/jc.2014-2774 [Epub 2014/10/04, PubMed PMID: 25279500]
    • (2014) J Clin Endocrinol Metab , pp. jc20142774
    • Farr, O.M.1    Fiorenza, C.2    Papageorgiou, P.3    Brinkoetter, M.4    Ziemke, F.5    Koo, B.B.6    Rojas, R.7    Mantzoros, C.S.8
  • 39
    • 84878366818 scopus 로고    scopus 로고
    • Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice
    • H.S. Moon, F. Dincer, and C.S. Mantzoros Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice Diabetologia 56 3 2013 627 634
    • (2013) Diabetologia , vol.56 , Issue.3 , pp. 627-634
    • Moon, H.S.1    Dincer, F.2    Mantzoros, C.S.3
  • 40
    • 79951716553 scopus 로고    scopus 로고
    • Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: In vitro and ex vivo studies in humans
    • H.S. Moon, J.P. Chamberland, K.N. Diakopoulos, C.G. Fiorenza, F. Ziemke, B. Schneider, and C.S. Mantzoros Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans Diabetes Care 34 1 2011 132 138
    • (2011) Diabetes Care , vol.34 , Issue.1 , pp. 132-138
    • Moon, H.S.1    Chamberland, J.P.2    Diakopoulos, K.N.3    Fiorenza, C.G.4    Ziemke, F.5    Schneider, B.6    Mantzoros, C.S.7
  • 41
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
    • R.H. Unger, and A.D. Cherrington Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover J Clin Invest 122 1 2012 4 12
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.