Compound IMM-H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia

CNS Neuroscience and Therapeutics

Volumn 21, Issue 3, 2015, Pages 280-288

  Zuo, Wei ^a   Zhang, Wei ^b   Han, Ning ^a   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Global cerebral ischemia; Hippocampus; IMM H004; Neuroprotection

Indexed keywords

7 HYDROXY 5 METHOXY 4 METHYL 3 (4 METHYLPIPERAZIN 1 YL) 2H CHROMEN 2 ONE; CASPASE 3; COUMARIN DERIVATIVE; NORPHENAZONE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN BAX; PROTEIN BCL 2; SYNAPSIN I; UNCLASSIFIED DRUG; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; DLGH4 PROTEIN, RAT; IMM-H004; MEMBRANE PROTEIN; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER; SIGNAL PEPTIDE; SYNAPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; ELECTRON MICROSCOPY; HIPPOCAMPAL CA1 REGION; IMMUNOBLOTTING; LEARNING DISORDER; MALE; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SPATIAL LEARNING; SPATIAL MEMORY; SYNAPTIC EFFICACY; TRANSIENT GLOBAL ISCHEMIA; TRANSIENT ISCHEMIC ATTACK; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN ISCHEMIA; CELL DEATH; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; LEARNING DISORDERS; MAZE TEST; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIPYRINE; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; CASPASE 3; CELL DEATH; COUMARINS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMBRANE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SPATIAL MEMORY; SYNAPSINS;

EID: 84923945958     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12364     Document Type: Article

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