IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation

European Journal of Neuroscience

Volumn 39, Issue 12, 2014, Pages 2107-2118

  Zuo, Wei ^a   Chen, Jiao ^a,b   Zhang, Shuai ^a   Tang, Jia ^a   Liu, Hang ^a   Zhang, Dongming ^a   Chen, Naihong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Astrocytes; Blood brain barrier; Microvascular endothelial cells; Vascularization

Indexed keywords

ADENOSINE TRIPHOSPHATE; COUMARIN DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GELATINASE A; GELATINASE B; IMM HOO4; LACTATE DEHYDROGENASE; OCCLUDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; FIBRINOLYTIC AGENT; IMM-H004; NEUROPROTECTIVE AGENT; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CELL CULTURE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; THERAPY DELAY; WESTERN BLOTTING; ANIMAL; BRAIN; CELL CULTURE; CEREBRAL HEMORRHAGE; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PC12 CELL LINE; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; THROMBOEMBOLISM; TIME;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELLS, CULTURED; CEREBRAL HEMORRHAGE; COUMARINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FIBRINOLYTIC AGENTS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; THROMBOEMBOLISM; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84902477747     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12551     Document Type: Article

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