A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice

Journal of Neurochemistry

Volumn 121, Issue 6, 2012, Pages 1007-1013

  Wang, Chen ^a   Pei, Aijie ^a   Chen, Jing ^a   Yu, Hailong ^a   Sun, Mei Ling ^a   Liu, Chun Feng ^a   Xu, Xingshun ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral ischemia; Esculetin; Middle cerebral artery occlusion; Neuroprotection

Indexed keywords

CASPASE 3; ESCULETIN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; ENZYME ACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REPERFUSION INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; REPERFUSION INJURY; UMBELLIFERONES;

MUS;

EID: 84862011705     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07744.x     Document Type: Article

References (31)

1. Asahi M., Hoshimaru M., Uemura Y. et al. (1997) Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J. Cereb. Blood Flow Metab. 17, 11-18. (Pubitemid 27014903)
2. Broughton B. R., Reutens D. C. and Sobey C. G. (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40, e331-339.
3. Chaudhry P., Singh M., Parent S. and Asselin E. (2012) Prostate apoptosis response-4 (par-4): a novel substrate of caspase-3 during apoptosis activation. Mol. Cell. Biol. 32, 826-839.
4. Cheng Y. D., Al-Khoury L. and Zivin J. A. (2004) Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 1, 36-45. (Pubitemid 46589340)
5. Iadecola C. and Anrather J. (2011) Stroke research at a crossroad: asking the brain for directions. Nat. Neurosci. 14, 1363-1368.
6. Kim S. H., Kang K. A., Zhang R. et al. (2008) Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species. Acta Pharmacol. Sin. 29, 1319-1326.
7. Kok S. H., Yeh C. C., Chen M. L. and Kuo M. Y. (2009) Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells. Oral Oncol. 45, 1067-1072.
8. Kuo H. C., Lee H. J., Hu C. C., Shun H. I. and Tseng T. H. (2006) Enhancement of esculetin on Taxol-induced apoptosis in human hepatoma HepG2 cells. Toxicol. Appl. Pharmacol. 210, 55-62.
9. Kwon O. S., Choi J. S., Islam M. N., Kim Y. S. and Kim H. P. (2011) Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Arch. Pharm. Res. 34, 1561-1569.
10. Lee C. R., Shin E. J., Kim H. C., Choi Y. S., Shin T. and Wie M. B. (2011a) Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures. Lab. Anim. Res. 27, 259-263.
11. Lee S. J., Lee U. S., Kim W. J. and Moon S. K. (2011b) Inhibitory effect of esculetin on migration, invasion and matrix metalloproteinase-9 expression in TNF-alpha-induced vascular smooth muscle cells. Mol. Med. Report 4, 337-341.
12. Lin T. H., Lu F. J., Yin Y. F. and Tseng T. H. (2009) Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells. Chem. Biol. Interact. 180, 61-68.
13. Medcalf R. L. (2011) Plasminogen activation-based thrombolysis for ischaemic stroke: the diversity of targets may demand new approaches. Curr. Drug Targets 12, 1772-1781.
14. Meloni B. P., Meade A. J., Kitikomolsuk D. and Knuckey N. W. (2011) Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models. J. Neurosci. Methods 195, 67-74.
15. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K. J., Yuan J. and Moskowitz M. A. (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18, 3659-3668. (Pubitemid 28225674)
16. Pan S. L., Huang Y. W., Guh J. H., Chang Y. L., Peng C. Y. and Teng C. M. (2003) Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats. Biochem. Pharmacol. 65, 1897-1905.
17. Park C., Jin C. Y., Kim G. Y., Choi I. W., Kwon T. K., Choi B. T., Lee S. J., Lee W. H. and Choi Y. H. (2008) Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. Toxicol. Appl. Pharmacol. 227, 219-228. (Pubitemid 351231936)
18. Park S. S., Park S. K., Lim J. H., Choi Y. H., Kim W. J. and Moon S. K. (2011) Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells. Oncol. Rep. 25, 223-230.
19. Roger V. L., Go A. S., Lloyd-Jones D. M. et al. (2012) Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 125, e2-e220.
20. Sahota P. and Savitz S. I. (2011) Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics 8, 434-451.
21. Sharma V. K., Teoh H. L., Wong L. Y., Su J., Ong B. K. and Chan B. P. (2010) Recanalization therapies in acute ischemic stroke: pharmacological agents, devices, and combinations. Stroke Res. Treat. 2010, 672064.
22. Tien Y. C., Liao J. C., Chiu C. S., Huang T. H., Huang C. Y., Chang W. T. and Peng W. H. (2011) Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. Int. J. Mol. Sci. 12, 4053-4067.
23. Tymianski M. (2011) Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat. Neurosci. 14, 1369-1373.
24. Witaicenis A., Seito L. N. and Di Stasi L. C. (2010) Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. Chem. Biol. Interact. 186, 211-218.
25. Wu P. F., Zhang Z., Wang F. and Chen J. G. (2010) Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury. Acta Pharmacol. Sin. 31, 1523-1531.
26. Xu M. and Zhang H. L. (2011) Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol. Sin. 32, 1089-1099.
27. Xu X., Chua C. C., Gao J., Hamdy R. C. and Chua B. H. (2006) Humanin is a novel neuroprotective agent against stroke. Stroke 37, 2613-2619. (Pubitemid 44454687)
28. Xu X., Chua C. C., Gao J., Chua K. W., Wang H., Hamdy R. C. and Chua B. H. (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res. 1227, 12-18.
29. Xu X., Chua K. W., Chua C. C., Liu C. F., Hamdy R. C. and Chua B. H. (2010) Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res. 1355, 189-194.
30. Yang J., Xiao Y. L., He X. R., Qiu G. F. and Hu X. M. (2010) Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J. Asian Nat. Prod. Res. 12, 185-193.
31. Yun E. S., Park S. S., Shin H. C., Choi Y. H., Kim W. J. and Moon S. K. (2011) p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation. Toxicol. In Vitro 25, 1335-1342.