Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Biochemical Pharmacology

Volumn 94, Issue 2, 2015, Pages 91-100

  Semaan, Walid ^a   Desbiens, Louisane ^a   Houde, Martin ^a   Labonté, Julie ^a   Gagnon, Hugo ^b   Yamamoto, Daisuke ^c   Takai, Shinji ^c   Laidlaw, Tanya ^d   Bkaily, Ghassan ^a   Schwertani, Adel ^e   Pejler, Gunnar ^f   Levesque, Christine ^a   Desjardins, Roxane ^a   Day, Robert ^a   D'Orléans Juste, Pedro ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b PhenoSwitch Bioscience Inc   (Canada)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d HARVARD UNIVERSITY   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Chymase; Mass spectrometry; Radiotelemetry In silico analysis; Recombinant enzymes

Indexed keywords

ANGIOTENSIN II; CHYMASE; CHYMASE INHIBITOR; ENDOTHELIN 1; RECOMBINANT ENZYME; TY 51469; UNCLASSIFIED DRUG; ENDOTHELIN-1 (1-31); ENZYME INHIBITOR; MAST CELL PROTEASE 4; PEPTIDE FRAGMENT; SERINE PROTEINASE;

ANIMAL CELL; AORTA; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PERITONEUM MAST CELL; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; GENETICS; METABOLISM; SYNTHESIS;

ANIMALS; CHROMATOGRAPHY, LIQUID; CHYMASES; ENDOTHELIN-1; ENZYME INHIBITORS; HUMANS; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; SERINE ENDOPEPTIDASES; TANDEM MASS SPECTROMETRY;

EID: 84923923828     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.02.001     Document Type: Article

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