Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Ricci, Susanna ^a,f   Grandgirard, Denis ^b,f   Wenzel, Michael ^c,g   Braccini, Tiziana ^a   Salvatore, Paola ^d   Oggioni, Marco R ^e,f   Leib, Stephen L ^b,f   Koedel, Uwe ^c,f  

^a UNIVERSITY HOSPITAL OF SIENA   (Italy)

^b UNIVERSITY OF BERN   (Switzerland)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f The ESCMID Study Group for Infectious Diseases of the Brain (ESGIB)   (Switzerland)

^g Columbia University Biological Sciences ^*  (United States)

Author keywords

Brain damage; Matrix metalloproteinases; Meningococcal meningitis; Metalloproteinase inhibitors; Mouse model; Neisseria meningitidis

Indexed keywords

BATIMASTAT; BIOLOGICAL MARKER; GELATINASE B; MATRIX METALLOPROTEINASE; CHEMOKINE; CYTOKINE; GELATINASE A; MATRIX METALLOPROTEINASE INHIBITOR; PHENYLALANINE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DAMAGE; BRAIN HEMORRHAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; EPIDEMIC MENINGITIS; FEMALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; SURVIVAL RATE; ZYMOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; CEREBELLUM; CEREBRAL HEMORRHAGE; COMPLICATION; DENTATE GYRUS; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; KAPLAN MEIER METHOD; MENINGITIS, MENINGOCOCCAL; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; CEREBELLUM; CEREBRAL HEMORRHAGE; CHEMOKINES; CYTOKINES; DENTATE GYRUS; DISEASE MODELS, ANIMAL; FEMALE; KAPLAN-MEIER ESTIMATE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; MENINGITIS, MENINGOCOCCAL; MICE; PHENYLALANINE; THIOPHENES;

EID: 84923917674     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-014-0726-6     Document Type: Article

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