In pneumococcal meningitis a novel water-soluble inhibitor of matrix metalloproteinases and TNF-α converting enzyme attenuates seizures and injury of the cerebral cortex

Journal of Neuroimmunology

Volumn 151, Issue 1-2, 2004, Pages 6-11

  Meli, D N ^a   Loeffler, J M ^a   Baumann, P ^a   Neumann, U ^b   Buhl, T ^b   Leppert, D ^c   Leib, S L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Bacterial meningitis; Matrix metalloproteinases; Tumor necrosis factor alpha converting enzyme

Indexed keywords

CEFTRIAXONE; COLLAGEN; HYDROXYPROLINE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; TNF 484; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MENINGITIS; BRAIN CORTEX; BRAIN INJURY; CEREBROSPINAL FLUID; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PENETRATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; TREATMENT OUTCOME;

ADAM PROTEINS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; MATRIX METALLOPROTEINASES; MENINGITIS, PNEUMOCOCCAL; METALLOENDOPEPTIDASES; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 2442451453     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.01.026     Document Type: Article

References (25)

1. Bedford H., de Louvois J., Halket S., Peckham C., Hurley R., Harvey D. BMJ. 323:2001;533-536
2. Black R.A., Rauch C.T., Kozlosky C.J., Peschon J.J., Slack J.L., Wolfson M.F., Castner B.J., Stocking K.L., Reddy P., Srinivasan S., Nelson N., Boiani N., Schooley K.A., Gerhart M., Davis R., Fitzner J.N., Johnson R.S., Paxton R.J., March C.J., Cerretti D.P. Nature. 385:1997;729-733
3. Bogdan I., Leib S.L., Bergeron M., Chow L., Täuber M.G. J. Infect. Dis. 176:1997;693-697
4. Hallenbeck J.M. Nat. Med. 8:2002;1363-1368
5. Ho K.C., Pang C.P. Clin. Chim. Acta. 185:1989;191-195
6. Hurtado O., Lizasoain I., Fernandez-Tome P., Alvarez-Barrientos A., Leza J.C., Lorenzo P., Moro M.A. J. Cereb. Blood Flow Metab. 22:2002;576-585
7. Koedel U., Scheld W.M., Pfister H.W. Lancet, Infect. Dis. 2:2002;721-736
8. Kottirsch G., Koch G., Feifel R., Neumann U. J. Med. Chem. 45:2002;2289-2293
9. Leib S.L., Leppert D., Clements J., Täuber M.G. Infect. Immun. 68:2000;615-620
10. Leib S.L., Clements J.M., Lindberg R.L., Heimgartner C., Loeffler J.M., Pfister L.A., Täuber M.G., Leppert D. Brain. 124:2001;1734-1742
11. Leppert D., Leib S.L., Grygar C., Miller K.M., Schaad U.B., Hollander G.A. Clin. Infect. Dis. 31:2000;80-84
12. Leppert D., Lindberg R.L., Kappos L., Leib S.L. Brain Res. Brain Res. Rev. 36:2001;249-257
13. Loeffler J.M., Ringer R., Hablutzel M., Täuber M.G., Leib S.L. J. Infect. Dis. 183:2001;247-252
14. Meli D.N., Christen S., Leib S.L., Täuber M.G. Curr. Opin. Infect. Dis. 15:2002;253-257
15. Meli D.N., Christen S., Leib S.L. J. Infect. Dis. 187:2003;1411-1415
16. Nau R., Soto A., Bruck W. J. Neuropathol. Exp. Neurol. 58:1999;265-274
17. Paul R., Lorenzl S., Koedel U., Sporer B., Vogel U., Frosch M., Pfister H.W. Ann. Neurol. 44:1998;592-600
18. Rivera S., Ogier C., Jourquin J., Timsit S., Szklarczyk A.W., Miller K., Gearing A.J., Kaczmarek L., Khrestchatisky M. Eur. J. Neurosci. 15:2002;19-32
19. Rosenberg G.A., Estrada E.Y., Dencoff J.E., Stetler-Stevenson W.G. Brain Res. 703:1995;151-155
20. Rosenberg G.A., Cunningham L.A., Wallace J., Alexander S., Estrada E.Y., Grossetete M., Razhagi A., Miller K., Gearing A. Brain Res. 893:2001;104-112
21. Schaper M., Leib S.L., Meli D.N., Brandes R.P., Täuber M.G., Christen S. Infect. Immun. 71:2003;4087-4092
22. Talley A.K., Dewhurst S., Perry S.W., Dollard S.C., Gummuluru S., Fine S.M., New D., Epstein L.G., Gendelman H.E., Gelbard H.A. Mol. Cell. Biol. 15:1995;2359-2366
23. Trifilieff A., Walker C., Keller T., Kottirsch G., Neumann U. Br. J. Pharmacol. 135:2002;1655-1664
24. Whittaker M., Floyd C.D., Brown P., Gearing A.J. Chem. Rev. 99:1999;2735-2776
25. Williams L.M., Gibbons D.L., Gearing A., Maini R.N., Feldmann M., Brennan F.M. J. Clin. Invest. 97:1996;2833-2841