Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis

Infection and Immunity

Volumn 74, Issue 7, 2006, Pages 3890-3896

  Meli, Damian N ^a   Coimbra, Roney S ^a   Erhart, Dominik G ^a   Loquet, Gerard ^b   Bellac, Caroline L ^a   Täuber, Martin G ^a   Neumann, Ulf ^c   Leib, Stephen L ^a,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Institute for Infectious Diseases   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; DOXYCYCLINE; MATRIX METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOMETRY; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; BRAIN INJURY; CELL DEATH; COCHLEA; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; EVOKED BRAIN STEM AUDITORY RESPONSE; EXPERIMENTAL INFECTION; EYE INJURY; FEMALE; HEARING LOSS; INFLAMMATORY CELL; MEDIATOR RELEASE; MORTALITY; NONHUMAN; PERCEPTION DEAFNESS; PRIORITY JOURNAL; RAT; SPIRAL GANGLION; SYMPTOMATOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CEFTRIAXONE; COCHLEA; DOXYCYCLINE; FEMALE; INJECTIONS, SUBCUTANEOUS; MENINGITIS, PNEUMOCOCCAL; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745597371     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01949-05     Document Type: Article

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