Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 6, 2015, Pages 1206-1211

  Chirkova, Zhanna V ^a   Kabanova, Mariya V ^a   Filimonov, Sergey I ^a   Abramov, Igor G ^a   Petzer, Anél ^b   Petzer, Jacobus P ^b   Firgang, Sergey I ^c   Suponitsky, Kyrill Yu ^d  

^a YAROSLAVL STATE TECHNICAL UNIVERSITY   (Russian Federation)

^b NORTH WEST UNIVERSITY   (South Africa)

^c N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^d A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

Author keywords

Indole 5,6 dicarbonitrile; Inhibition; MAO; Monoamine oxidase; Phthalonitrile; Reversible

Indexed keywords

3 BROMO 1 HYDROXY 1H INDOLE 5,6 DICARBONITRILE DICARBONITRILE; 3 BROMO 1 METHYL 1H INDOLE 5,6 DICARBONITRILE DERIVATIVE; 3 CHLORO 1 METHYL 1H INDOLE 5,6 DICARBONITRILE DERIVATIVE; 3 CHLORO 1H INDOLE 5,6 DICARBONITRILE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; INDOLE 5,6 DICARBONITRILE DERIVATIVE; INDOLE DERIVATIVE; LAZABEMIDE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; NITRILE; PARGYLINE; TOLOXATONE; UNCLASSIFIED DRUG; INDOLE; ISOPROTEIN; MONOAMINE OXIDASE INHIBITOR; PROTEIN BINDING;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC50; METHYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; HUMAN; KINETICS; METABOLISM; X RAY CRYSTALLOGRAPHY;

GYMNOMYZA;

CRYSTALLOGRAPHY, X-RAY; HUMANS; INDOLES; KINETICS; MOLECULAR CONFORMATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NITRILES; PROTEIN BINDING; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923912729     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.01.061     Document Type: Article

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