PyNTTTTGT and CpG immunostimulatory oligonucleotides: Effect on Granulocyte/Monocyte Colony-Stimulating Factor (GM-CSF) secretion by human CD56+ (NK and NKT) cells

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Rodriguez, Juan M ^a   Marchicio, José ^b   López, Mariela ^b   Ziblat, Andrea ^b   Elias, Fernanda ^b   Fló, Juan ^b   López, Ricardo A ^b   Horn, David ^c   Zorzopulos, Jorge ^b   Montaner, Alejandro D ^d  

^a Fundacion Pablo Cassara   (Argentina)

^b Immunotech SA   (Argentina)

^c David Horn LLC   (United States)

^d Instituto de Ciencia y Tecnología Dr Cesar Milstein   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD56 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; OLIGONUCLEOTIDE; PYRIMIDYLADENYLCYTOSYLTHYMIDYLTHYMIDYLTHYMIDYLTHYMIDYLGUANYLTHYMIDINE; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CPG-OLIGONUCLEOTIDE; IMT504; INTERLEUKIN 8; OLIGODEOXYRIBONUCLEOTIDE;

ARTICLE; CELL POPULATION; CONTROLLED STUDY; CPG ISLAND; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOSTIMULATION; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PROTEIN MOTIF; DRUG EFFECTS; NATURAL KILLER T CELL; SECRETION (PROCESS);

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-ALPHA; INTERFERON-GAMMA; INTERLEUKIN-2; INTERLEUKIN-8; KILLER CELLS, NATURAL; NATURAL KILLER T-CELLS; OLIGODEOXYRIBONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923809782     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117484     Document Type: Article

References (37)

1. Krieg AM (2002) CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 20: 709-760. PMID: 11861616
2. Elías F, Fló J, Lopez RA, Zorzopulos J, Montaner AD, Rodriguez J (2003) Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs. J Immunol 171: 3697-3704. PMID: 14500668
3. Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, et al. (2003) Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells. Eur J Immunol 33: 1633-1641. PMID: 12778481
4. Jurk M, Schulte B, Kritzler A, Noll B, Uhlmann E, et al. (2004) C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level. Immunobiology 209: 141-154. PMID: 15481148
5. Abel K, Wang Y, Fritts L, Sanchez E, et al. (2005) Deoxycytidyl-Deoxyguanosine Oligonucleotide Classes A, B, and C Induce Distinct Cytokine Gene Expression Patterns in Rhesus Monkey Peripheral Blood Mononuclear Cells and Distinct Alpha Interferon Responses in TLR9-Expressing Rhesus Monkey Plasmacytoid Dendritic Cells. Clin Vaccine Immunol 12: 606-621.
6. Krug A, Rothenfusser S, Hornung V, Jahrsdörfer B, Blackwell S, et al. (2001) Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 31: 2154-2163. PMID: 11449369
7. Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, et al. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A 98: 9237-9242. PMID: 11470918
8. Kerkmann M, Costa LT, Richter C, Rothenfusser S, Battiany J, et al. (2005) Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in Plasmacytoid Dendritic Cells. J Biol Chem 280: 8086-8093. PMID: 15591070
9. Verthelyi D, Ishii KJ, Gursel M, Takeshita F, Klinman DM (2001) Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs. J Immunol 166: 2372-2377. PMID: 11160295
10. Krieg AM, Davis HL (2001) Enhancing vaccines with immune stimulatory CpG DNA. Curr Opin Mol Ther. 3(1): 15-24. PMID: 11249727
11. Scheiermann J, Klinman DM (2014) Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer. Vaccine 32(48): 6377-6389. doi: 10.1016/j.vaccine.2014.06.065 PMID: 24975812
12. Elias F, Flo J, Rodriguez JM, De Nichilo A, Lopez R, et al. (2005) PyNTTTTGT prototype oligonucleotide IMT504 is a potent adjuvant for the recombinant Hepatitis B vaccine that enhances the Th1 response. Vaccine 23: 3597-603. PMID: 15855019
13. Zhao G, Jin H, Li J, Su B, Du X, et al. (2009) PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine. Viral Immunol. 22(2): 131-138. doi: 10.1089/vim.2008.0073 PMID: 19327000
14. Montaner AD, Denichilo A, Rodríguez JM, Fló J, López R, et al. (2011) Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire. Nucleic Acid Ther 21: 265-274. doi: 10.1089/nat.2011.0284 PMID: 21793787
15. Montaner AD, De Nichilo A, Rodriguez JM, Hernando Insua A, Fló J, et al. (2012) IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing. W J V 2(4): 182-188.
16. Hernando-Insua A, Montaner AD, Rodriguez JM, Elias F, Flo J, et al. (2007) IMT504, the prototype of the immunostimulatory oligonucleotides of the PyNTTTTGT class, increases the number of progenitors of mesenchymal stem cells both in vitro and in vivo: potential use in tissue repair therapy. Stem Cells 25: 1047-1054. PMID: 17420228
17. Insúa A, Montaner AD, Rodriguez JM, Elías F, Fló J, et al. (2007) PyNTTTTGT Oligonucleotides as Tools in Tissue Repair Procedures. In Ashammakhi N, Reis R & Chiellini E editors. Topics in Tissue Engineering. Italy. Vol. 3; Chapter 11, pp1-12.
18. Bianchi M, Hernando-Insúa A, Chasseing N, Rodríguez JM, Elías F, et al. (2011) Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers. Diabetologia 53: 1184-1189.
19. Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, et al. (2011) Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. Nat Immunol 12: 1202-1211. doi: 10.1038/ni.2143 PMID: 22037601
20. Moretta A, Marcenaro E, Parolini S, Ferlazzo G and Moretta L (2008) NK cells at the interface between innate and adaptive immunity. Cell Death Differ 15: 226-233. PMID: 17541426
21. + T Cell-Dependent Activation of NK Cells Following Vaccination. J Immunol 185: 2808-2818.
22. Bessoles S, Fouret F, Dudal S, Besra GS, Sanchez F et al. (2008) IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines. J Leukoc Biol 84: 224-233. doi: 10.1189/jlb.1007669 PMID: 18456817
23. Kerkman M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, et al. (2003) Activation with CpG-A and CpG-B Oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J Immunol 170: 4465-4474. PMID: 12707322
24. Fitzgerald-Bocarsly P, Jihong D, Sukhwinder S. (2008) Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev 19(1): 3-19. doi: 10.1016/j.cytogfr.2007.10.006 PMID: 18248767
25. Shi Y, Liu CH, Roberts AI, Das J, Xu, et al. (2006) Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res 16: 126-133 PMID: 16474424
26. Landrigan A, Wong MT, Utz PJ (2011) CpG and Non-CpG Oligonucleotides Directly Costimulate Mouse and Human CD4+ T Cells through a TLR9- and MyD88-Independent Mechanism. J Immunol 187: 3033-3043. doi: 10.4049/jimmunol.1003414 PMID: 21844387
27. Liu YC, Gray RC, Hardy GAD, Kuchtey J, Abbott DW, et al. (2010) CpG-B Oligodeoxynucleotides Inhibit TLR-Dependent and - Independent Induction of Type I IFN in Dendritic Cells. J Immunol 184: 3367-3376. doi: 10.4049/jimmunol.0903079 PMID: 20181884
28. Levitt LJ, Nagler A, Lee F, Abrams J, Shatsky M et al. (1991) Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor. J Clin Invest. 88: 67-75. PMID: 1676038
29. Marshall JD, Heeke DS, Abbate C, Yee P, Van Nest G (2006) Induction of interferon-γ from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid-dendritic-cell-produced interferon-α and tumour necrosis factor-α. Immunology 117: 38-46. PMID: 16423039
30. Vollmer J, Weeratna R, Payette P, Jurk M, Schetter C, et al. (2004) Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 34: 251-262. PMID: 14971051
31. Issazadeh-Navikas S (2012) NKT cell self-reactivity: evolutionary master key of immune homeostasis?J Mol Cell Biol 4(2): 70-78, doi: 10.1093/jmcb/mjr035 PMID: 22167750
32. Tyznik AJ, Tupin E, Nagarajan NA, Her MJ, Benedict CA et al. (2008) The mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181: 4452-4456. PMID: 18802047
33. Paget C, Ivanov S, Fontaine J, Renneson J, Blanc F, et al. (2012) Interleukin-22 is produced by invariant natural killer T lymphocytes during Influenza A virus infection: potential role in protection against lung epithelial damages. J Biol Chem 287: 8816-8829. doi: 10.1074/jbc.M111.304758 PMID: 22294696
34. Lee IF, van den Elzen P, Tan R, Priatel JJ (2011) NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes. J Immunol 187(6): 2898-2904. doi: 10.4049/jimmunol.1002551 PMID: 21844383
35. Novak J, Lehuen A (2011) Mechanism of regulation of autoimmunity by iNKT cells. Cytokine 53: 263-270. doi: 10.1016/j.cyto.2010.11.001 PMID: 21185200
36. Urban EM, Li H, Armstrong C, Focaccetti C, Cairo C et al. (2009) Control of CD56 expression and tumor cell cytotoxicity in human Vgamma2Vdelta2 T cells. BMC Immunol. 10: 50. doi: 10.1186/1471-2172-10-50 PMID: 19772585
37. Coronel MF, Hernando-Insúa A, Rodriguez JM, Elias F, Chasseing N, et al. (2008) Oligonucleotide IMT504 reduces neuropathic pain after peripheral nerve injury. Neurosci Lett 444: 69-73. doi: 10.1016/j.neulet.2008.07.045 PMID: 18672022