Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: Correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers

Diabetologia

Volumn 53, Issue 6, 2010, Pages 1184-1189

  Bianchi, M S ^a,e   Hernando Insua A ^b,c   Chasseing, N A ^a,e   Rodriguez J M ^c   Elias F ^c   Lago, N ^d   Zorzopulos, J ^b   Libertun, C ^a,e   Montaner, A D ^b,c   Lux Lantos, V A ^a,e  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b Immunotech SA   (Argentina)

^c Fundacion Pablo Cassara   (Argentina)

^d Gema Biotech   (Argentina)

^e V de Obligado 2490 ^*  (Argentina)

Author keywords

Glycaemia; IMT504; Islet recovery; Nestin; NGN3; Oligodeoxynucleotide; PCNA; Progenitors; STZ

Indexed keywords

CYCLINE; GLUCOSE; IMT 504; NESTIN; NEUROGENIN 3; OLIGODEOXYNUCLEOTIDE; SODIUM CHLORIDE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENDOTHELIUM CELL; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; STREPTOZOCIN DIABETES;

ANALYSIS OF VARIANCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOOD GLUCOSE; CELL COUNT; DIABETES MELLITUS, EXPERIMENTAL; EATING; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTERMEDIATE FILAMENT PROTEINS; MALE; NERVE TISSUE PROTEINS; OLIGODEOXYRIBONUCLEOTIDES; PANCREAS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; STEM CELLS; TREATMENT OUTCOME;

EID: 77952094047     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1694-z     Document Type: Article

References (11)

1. E Nikoopour JA Schwartz B Singh 2008 Therapeutic benefits of regulating inflammation in autoimmunity Inflamm Allergy Drug Targets 7 203 210 10.2174/187152808785748155 1:CAS:528:DC%2BD1cXhtFCrtLbI 18782028
2. F Fallarino C Volpi T Zelante, et al. 2009 IDO mediates TLR9-driven protection from experimental autoimmune diabetes J Immunol 183 6303 6312 10.4049/jimmunol.0901577 1:CAS:528:DC%2BD1MXhtlKhsbbM 19841163
3. F Elias J Flo RA Lopez J Zorzopulos A Montaner JM Rodriguez 2003 Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs J Immunol 171 3697 3704 1:CAS:528:DC%2BD3sXnvFSrtbg%3D 14500668 (Pubitemid 37254574)
4. AM Krieg AK Yi S Matson, et al. 1995 CpG motifs in bacterial DNA trigger direct B-cell activation Nature 374 546 549 10.1038/374546a0 1:CAS:528:DyaK2MXkvVKqtr8%3D 7700380
5. IA Hernando AD Montaner JM Rodriguez, et al. 2007 IMT504, the prototype of the immunostimulatory oligonucleotides of the PyNTTTTGT class, increases the number of progenitors of mesenchymal stem cells both in vitro and in vivo: potential use in tissue repair therapy Stem Cells 25 1047 1054 10.1634/stemcells.2006-0479 (Pubitemid 46572603)
6. Su SC, Pei D, Hsieh CH, Hsiao FC, Wu CZ, Hung YJ (2010) Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes. Acta Diabetol. doi: 10.1007/s00592-009-0171-y
7. M Crisan S Yap L Casteilla, et al. 2008 A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 3 301 313 10.1016/j.stem.2008.07.003 1:CAS:528:DC%2BD1cXhtF2jtr%2FO 18786417
8. J Lardon I Rooman L Bouwens 2002 Nestin expression in pancreatic stellate cells and angiogenic endothelial cells Histochem Cell Biol 117 535 540 10.1007/s00418-002-0412-4 1:CAS:528:DC%2BD38XkslSnsb0%3D 12107504 (Pubitemid 34666957)
9. X Xu J D'Hoker G Stange, et al. 2008 Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas Cell 132 197 207 10.1016/j.cell.2007.12.015 1:CAS:528:DC%2BD1cXhvVSrtLc%3D 18243096 (Pubitemid 351181232)
10. X Gao L Song K Shen H Wang W Niu X Qin 2008 Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice Biochem Biophys Res Commun 371 132 137 10.1016/j.bbrc.2008.04.033 1:CAS:528: DC%2BD1cXlvVWgsbs%3D 18420028
11. NA Hanley KP Hanley PJ Miettinen T Otonkoski 2008 Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells? Mol Cell Endocrinol 288 79 85 10.1016/j.mce.2008.03.001 1:CAS:528:DC%2BD1cXmvVKrs7k%3D 18450368