Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease

Journal of Investigative Medicine

Volumn 62, Issue 7, 2014, Pages 927-933

  Sun, Xiaoyan ^a,b,c,d   Salat, David ^a,c   Upchurch, Kristen ^a,c,d   Deason, Rebecca ^e   Kowall, Neil ^a,c,d   Budson, Andrew ^a,b,c,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Neurology   (United States)

^c VA BOSTON HEALTHCARE SYSTEM   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TEXAS STATE UNIVERSITY   (United States)

Author keywords

Alzheimer disease; Axial diffusivity; Cholinergic pathway; Diffusion tensor imaging; Fractional anisotropy; Mild cognitive impairment; Radial diffusivity

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; EXTERNAL CAPSULE; FEMALE; GLOBAL AXIAL DIFFUSIVITY; GLOBAL FRACTIONAL ANISOTROPY; GLOBAL RADIAL DIFFUSIVITY; HUMAN; IN VIVO STUDY; LEFT HEMISPHERE; LIMBIC CORTEX; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; NEUROIMAGING; NEUROPATHOLOGY; RADIOLOGICAL PARAMETERS; WHITE MATTER; WHITE MATTER ABNORMALITY; ANISOTROPY; CASE CONTROL STUDY; DEMOGRAPHY; PATHOLOGY;

AGED; ALZHEIMER DISEASE; ANISOTROPY; CASE-CONTROL STUDIES; DEMOGRAPHY; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; WHITE MATTER;

EID: 84923790437     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.1097/JIM.0000000000000102     Document Type: Article

References (49)

1. Kantarci K. Magnetic resonance markers for early diagnosis and progression of Alzheimer's disease. Expert Rev Neurother. 2005;5:663-670.
2. Stout JC, Jernigan TL, Archibald SL, et al. Association of dementia severity with cortical gray matter and abnormal white matter volumes in dementia of the Alzheimer type. Arch Neurol. 1996;53:742-749.
3. Kilimann I, Grothe M, Heinsen H, et al. Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study. J Alzheimers Dis. 2014;40:687-700.
4. Teipel SJ, Meindl T, Grinberg L, et al. The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study. Hum Brain Mapp. 2011;32:1349-1362.
5. Schliebs R, Arendt T. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm. 2006;113:1625-1644.
6. Teipel SJ, Grothe M, Lista S, et al. Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease. Med Clin North Am. 2013;97:399-424.
7. Masdeu JC, Kreisl WC, Berman KF. The neurobiology of Alzheimer disease defined by neuroimaging. Curr Opin Neurol. 2012;25: 410-420.
8. Chevalier-Larsen E, Holzbaur EL. Axonal transport and neurodegenerative disease. Biochim Biophys Acta. 2006;1762: 1094-1108.
9. Gold BT, Johnson NF, Powell DK, et al. White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta. 1822;2012:416-422.
10. Stokin GB, Lillo C, Falzone TL, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005;307:1282-1288.
11. Agosta F, Pievani M, Sala S, et al. White matter damage in Alzheimer disease and its relationship to gray matter atrophy. Radiology. 2011;258:853-863.
12. Canu E, McLaren DG, Fitzgerald ME, et al. Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer's disease. J Alzheimers Dis. 2010;19:963-976.
13. Salat DH, Tuch DS, van der Kouwe AJ, et al. White matter pathology isolates the hippocampal formation in Alzheimer's disease. Neurobiol Aging. 2010;31:244-256.
14. Stricker NH, Salat DH, Foley JM, et al. Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning. J Int Neuropsychol Soc. 2013;19: 925-937.
15. Oishi K, Mielke MM, Albert M, et al. DTI analyses and clinical applications in Alzheimer's disease. J Alzheimers Dis. 2011; 26(suppl 3):287-296.
16. Bosch B, Arenaza-Urquijo EM, Rami L, et al. Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol Aging. 2012;33:61-74.
17. Boespflug EL, Storrs J, Sadat-Hossieny S, et al. Full diffusion characterization implicates regionally disparate neuropathology in mild cognitive impairment. Brain Struct Funct. 2014;219:367-379.
18. Clerx L, Visser PJ, Verhey F, et al. New MRI markers for Alzheimer's disease: a meta-analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements. J Alzheimers Dis. 2012;29:405-429.
19. Sexton CE, Kalu UG, Filippini N, et al. A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2011;32:2322.e5-e18.
20. Douaud G, Jbabdi S, Behrens TE, et al. DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease. Neuroimage. 2011;55:880-890.
21. Weiner MW, Veitch DP, Aisen PS, et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement. 2012;8:S1-S68.
22. Nir TM, Jahanshad N, Villalon-Reina JE, et al. Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging. Neuroimage Clin. 2013;3:180-195.
23. Mori S, Oishi K, Jiang H, et al. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage. 2008;40:570-582.
24. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage. 2006;31:1487-1505.
25. Brun A, Englund E. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol. 1986;19: 253-262.
26. Englund E, Brun A, Alling C. White matter changes in dementia of Alzheimer's type. Biochemical and neuropathological correlates. Brain. 1988;111(Pt 6):1425-1439.
27. Sjobeck M, Haglund M, Englund E. Decreasing myelin density reflected increasing white matter pathology in Alzheimer's diseaseVa neuropathological study. Int J Geriatr Psychiatry. 2005;20:919-926.
28. Kowall NW, Kosik KS. Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol. 1987;22:639-643.
29. Stahl R, Dietrich O, Teipel SJ, et al. White matter damage in Alzheimer disease and mild cognitive impairment: assessment with diffusion-tensor MR imaging and parallel imaging techniques. Radiology. 2007;243:483-492.
30. Sydykova D, Stahl R, Dietrich O, et al. Fiber connections between the cerebral cortex and the corpus callosum in Alzheimer's disease: a diffusion tensor imaging and voxel-based morphometry study. Cereb Cortex. 2007;17:2276-2282.
31. Teipel SJ, Stahl R, Dietrich O, et al. Multivariate network analysis of fiber tract integrity in Alzheimer's disease. Neuroimage. 2007;34:985-995.
32. Zimny A, Szewczyk P, Trypka E, et al. Multimodal imaging in diagnosis of Alzheimer's disease and amnestic mild cognitive impairment: value of magnetic resonance spectroscopy, perfusion, and diffusion tensor imaging of the posterior cingulate region. J Alzheimers Dis. 2011;27:591-601.
33. Fjell AM, Amlien IK, Westlye LT, et al. Mini-mental state examination is sensitive to brain atrophy in Alzheimer's disease. Dement Geriatr Cogn Disord. 2009;28:252-258.
34. Heo JH, Lee ST, Kon C, et al. White matter hyperintensities and cognitive dysfunction in Alzheimer disease. J Geriatr Psychiatry Neurol. 2009;22:207-212.
35. Behl P, Bocti C, Swartz RH, et al. Strategic subcortical hyperintensities in cholinergic pathways and executive function decline in treated Alzheimer patients. Arch Neurol. 2007;64:266-272.
36. Bocti C, Swartz RH, Gao FQ, et al. A new visual rating scale to assess strategic white matter hyperintensities within cholinergic pathways in dementia. Stroke. 2005;36:2126-2131.
37. Kim HJ, Moon WJ, Han SH. Differential cholinergic pathway involvement in Alzheimer's disease and subcortical ischemic vascular dementia. J Alzheimers Dis. 2013;35:129-136.
38. Medina D, DeToledo-Morrell L, Urresta F, et al. White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study. Neurobiol Aging. 2006;27:663-672.
39. Selden NR, Gitelman DR, Salamon-Murayama N, et al. Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain. 1998;121(Pt 12):2249-2257.
40. Likitjaroen Y, Meindl T, Friese U, et al. Longitudinal changes of fractional anisotropy in Alzheimer's disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study. Eur Arch Psychiatry Clin Neurosci. 2012;262:341-350.
41. Kilimann I, Likitjaroen Y, Hampel H, et al. Diffusion tensor imaging to determine effects of antidementive treatment on cerebral structural connectivity in Alzheimer's disease. Curr Pharm Des. 2013;19:6416-6425.
42. Shah A, Jhawar SS, Goel A. Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques. J Clin Neurosci. 2012;19:289-298.
43. Triarhou LC. Centenary of Christfried Jakob's discovery of the visceral brain: an unheeded precedence in affective neuroscience. Neurosci Biobehav Rev. 2008;32:984-1000.
44. Hornberger M, Wong S, Tan R, et al. In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain. 2012;135:3015-3025.
45. Reid AT, Evans AC. Structural networks in Alzheimer's disease. Eur Neuropsychopharmacol. 2013;23:63-77.
46. Delbeuck X, Van der Linden M, Collette F. Alzheimer's disease as a disconnection syndrome? Neuropsychol Rev. 2003;13:79-92.
47. Thompson PM, Hayashi KM, de Zubicaray G, et al. Dynamics of gray matter loss in Alzheimer's disease. J Neurosci. 2003;23:994-1005.
48. Alves GS, O'Dwyer L, Jurcoane A, et al. Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients. PLoS One. 2012;7:e52859.
49. Zhang Y, Schuff N, Jahng GH, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007;68:13-19.