New MRI markers for alzheimer's disease: A meta-analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements

Journal of Alzheimer's Disease

Volumn 29, Issue 2, 2012, Pages 405-429

  Clerx, Lies ^a   Visser, Pieter Jelle ^a,b   Verhey, Frans ^a   Aalten, Pauline ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aging; Alzheimer's disease; diffusion tensor imaging; hippocampus; MRI

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CINGULATE GYRUS; COMPARATIVE STUDY; DIAGNOSTIC VALUE; DIFFUSION TENSOR IMAGING; DISEASE MARKER; FRACTIONAL ANISOTROPY; FRONTAL LOBE; HIPPOCAMPUS; HUMAN; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; OUTCOME ASSESSMENT; PARIETAL LOBE; PRIORITY JOURNAL; TEMPORAL LOBE;

EID: 84859410221     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110797     Document Type: Article

References (170)

1. Barnes DE, Yaffe K (2011) The projected effectofrisk factor reduction on Alzheimer's disease prevalence. Lancet Neurol 10, 819-828.
2. Jack CR, Shiung MM, Weigand SD, OBrien PC, Gunter JL, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Tangalos EG, Petersen RC (2005) Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology 65, 1227-1231. (Pubitemid 41508215)
3. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild Cognitive Impairment: Clinical Characterization and Outcome. Arch Neurol 56, 303-308. (Pubitemid 29120227)
4. Bruscoli M, Lovestone S (2004) Is MCI really just early dementia? A systematic review of conversion studies. Int Psychogeriatr 16, 129-140. (Pubitemid 38963102)
5. Dubois B, Feldman HH, Jacova C, DeKosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746. (Pubitemid 47058377)
6. Rusinek HP, Endo YM, De Santi SP, Frid DB, Tsui WHM, Segal SM, Convit AM, de Leon MJE (2004) Atrophy rate in medial temporal lobe during progression of Alzheimer disease. Neurology 63, 2354-2359.
7. Schoonenboom NSM, van der Flier WM, Blankenstein MA, Bouwman FH, Van Kamp GJ, Barkhof F, Scheltens P (2008) CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease. Neurobiol Aging 29, 669-675. (Pubitemid 351400823)
8. Visser PJ, Scheltens P, Verhey FRJ, Schmand B, Launer L, Jolles J, Jonker C (1999) Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J Neurol 246, 477-485. (Pubitemid 29326844)
9. Schmand B, Huizenga HM, van Gool WA (2010) Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease. Psychol Med 40, 135-145.
10. Medina D, deToledo-Morrell L, Urresta F, Gabrieli JDE, Moseley M, Fleischman D, Bennett DA, Leurgans S, Turner DA, Stebbins GT (2006) White matter changes in mild cognitive impairment and AD:Adiffusion tensor imaging study. Neurobiol Aging 27, 663-672.
11. Wang L, Goldstein FC, Veledar E, Levey AI, Lah JJ, Meltzer CC, Holder CA, Mao H (2009) Alterations in cortical thickness and white matter integrity inmild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging. AJNR Am J Neuroradiol 30, 893-899.
12. Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, Miller KL, Robson MD, Jones DK, Klein JC, Bartsch AJ, Behrens TEJ (2007) Acquisition and voxelwise analysis of multi-subject diffusion data with Tract-Based Spatial Statistics. Nat Protocols 2, 499-503.
13. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G (1996) Diffusion tensor MR imaging of the human brain. Radiology 201, 637-648.
14. Basser PJ, Mattiello J, Lebihan D (1994) Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo. J Magn Reson B 103, 247-254.
15. Stebbins GT, Murphy CM (2009) Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behav Neurol 21, 39-49.
16. Nakata Y, Sato N, Abe O, Shikakura S, Arima K, Furuta N, Uno M, Hirai S, Masutani Y, Ohtomo K, Aoki S (2008) Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: Tract-specific analysis.Radiat Med26, 466-473.
17. Bozzali M, Cherubini A (2007) Diffusion tensor MRI to investigate dementias: A brief review. Magn Reson Imaging 25, 969-977. (Pubitemid 47081370)
18. Medina DA, Gaviria M (2008) Diffusion tensor imaging investigations in Alzheimer's disease: The resurgence of white matter compromise in the cortical dysfunction of the aging brain. Neuropsychiatr Dis Treat 4, 737-742.
19. Sexton CE, Kalu UG, Filippini N, Mackay CE, Ebmeier KP (2011) A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 32, 2322.e5-18.
20. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J (1992) Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: Diagnostic value and neuropsychological correlates. J Neurol Neuro-surg Psychiatry 55, 967-972.
21. Hedges LV (1981) Distribution theory for Glass's Estimator of effect size and related estimators. J Educ Behav Stat 6, 107-128.
22. Cohen J (1988) Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum Associates, Hillsdale, New Jersey, USA.
23. Kempton MJ, Geddes JR, Ettinger U, Williams SCR, Grasby PM (2008) Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Arch Gen Psychiatry 65, 1017-1032.
24. Gavaghan DJ, Moore RA, McQuay HJ (2000) An evaluation of homogeneity tests in meta-analyses in pain using simulations of individual patient data. Pain 85, 415-424. (Pubitemid 30214168)
25. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7, 177-188. (Pubitemid 17189972)
26. Easterbrook PJ, Gopalan R, Berlin JA, Matthews DR (1991) Publication bias in clinical research. Lancet 337, 867-872.
27. Begg CB, Mazumdar M (1994) Operating Characteristics of a Rank Correlation Test for Publication Bias. Biometrics 50, 1088-1101.
28. Müller MJ, Greverus D, Dellani PR, Weibrich C, Wille PR, Scheurich A, Stoeter P, Fellgiebel A (2005) Functional implications of hippocampal volume and diffusivity in mild cognitive impairment. Neuroimage 28, 1033-1042. (Pubitemid 41713637)
29. Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ (2010) Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 133, 529-539.
30. Müller MJ, Greverus D, Weibrich C, Dellani PR, Scheurich A, Stoeter P, Fellgiebel A (2007) Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI. Neurobiol Aging 28, 398-403. (Pubitemid 46177388)
31. Sexton CE, Mackay CE, Lonie JA, Bastin ME, Terri Ëre E, O'Carroll RE, Ebmeier KP (2010) MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging. Psychiatry Res 184, 57-62.
32. Braak H, Braak E (1990) Neurofibrillary changesconfinedto the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia. Acta Neuropathol (Berl) 80, 479-486. (Pubitemid 20316605)
33. Choo ILH, Lee DY, Oh JS, Lee JS, Lee DS, Song IC, Youn JC, Kim SG, Kim KW, Jhoo JH, Woo JI (2010) Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease. Neu-robiol Aging 31, 772-779.
34. Van Hoesen GW (1982) The parahippocampal gyrus: New observations regarding its cortical connections in the monkey. Trends Neurosci 5, 345-350.
35. deToledo-Morrell L, Stoub TR, Bulgakova M, Wilson RS, Bennett DA, Leurgans S, Wuu J, Turner DA (2004) MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiol Aging 25, 1197-1203. (Pubitemid 39094022)
36. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, Beckett LA, deToledo-Morrell L (2001) MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging 22, 747-754. (Pubitemid 33055614)
37. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, HänninenT, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala E-L, Vainio P, Vanninen R, Partanen K, Soininen H (2004) Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging 25, 303-310. (Pubitemid 38220965)
38. Di Paola M, Di Iulio F, Cherubini A, Blundo C, Casini AR, Sancesario G, Passafiume D, Caltagirone C, Spalletta G (2010) When, where, and how the corpus callosum changes in MCI and AD: A multimodal MRI study. Neurology 74, 1136-1142.
39. Chen T-F, Lin C-C, Chen Y-F, Liu H-M, Hua M-S, Huang Y-C, Chiu M-J (2009) Diffusion tensorchangesinpatients with amnesic mild cognitive impairment and various dementias. Psychiatry Res 173, 15-21.
40. Serra L, Cercignani M, Lenzi D, Perri R, Fadda L, Calta-girone C, Macaluso E, Bozzali M (2010) Grey and white matter changes at different stages of Alzheimer's disease. J Alzheimers Dis 19, 147-159.
41. Wang H, Su MY (2006) Regional pattern of increased water diffusivity in hippocampus and corpus callosum in mild cognitive impairment. Dement Geriatr Cogn Disord 22, 223-229. (Pubitemid 44310518)
42. Callen DJA, Black SE, Gao F, Caldwell CB, Szalai JP (2001) Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD. Neurology 57, 1669-1674. (Pubitemid 33055487)
43. Jones BF, Barnes J, Uylings HBM, Fox NC, Frost C, Witter MP, Scheltens P (2006) Differential regional atrophy of the cingulate gyrus in Alzheimer disease: A volumetric MRI study. Cereb Cortex 16, 1701-1708. (Pubitemid 44729908)
44. Jacobs HIL, Van Boxtel MPJ, Jolles J, Verhey FRJ, Uylings HBM (2012) Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings. Neurosci Biobehav Rev 36, 297-309.
45. Burgmans S, van Boxtel MPJ, Smeets F, Vuurman EFPM, Gronenschild EHBM, Verhey FRJ, Uylings HBM, Jolles J (2009) Prefrontal cortex atrophy predicts dementia over a six-year period. Neurobiol Aging 30, 1413-1419.
46. Sugihara S, Kinoshita T, Matsusue E, Fujii S, Ogawa T (2004) Usefulness of diffusion tensor imaging of white matter in Alzheimer disease and vascular dementia. Acta Radiol 45, 658-663. (Pubitemid 44112734)
47. Bozzali M, Falini A, Cercignani M, Baglio F, Farina E, Alberoni M, Vezzulli P, Olivotto F, Mantovani F, Shallice T, Scotti G, Canal N, Nemni R (2005) Brain tissue damage in dementia with Lewy bodies: An in vivo diffusion tensor MRI study. Brain 128, 1595-1604. (Pubitemid 41373678)
48. Zhang Y, Schuff N, Du A-T, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW (2009) White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain 132, 2579-2592.
49. Bosch B, Arenaza-Urquijo EM, Rami L, Sala-Llonch R, Junque C, Sole-Padulles C, Pena-Gomez C, Bargallo N, Molinuevo JL, Bartres-Faz D (2012) Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol Aging 33, 61-74.
50. Salat DH, Tuch DS, van der Kouwe AJW, Greve DN, Pappu V, Lee SY, Hevelone ND, Zaleta AK, Growdon JH, Corkin S, Fischl B, Rosas HD (2010) White matter pathology isolates the hippocampal formation in Alzheimer's disease. Neurobiol Aging 31, 244-256.
51. Song S-K, Sun S-W, Ju W-K, Lin S-J, Cross AH, Neufeld AH (2003) Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 20, 1714-1722. (Pubitemid 37468277)
52. Sun S-W, Song S-K, Harms MP, Lin S-J, Holtzman DM, Merchant KM, Kotyk JJ (2005) Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging. Exp Neurol 191, 77-85. (Pubitemid 39612394)
53. Canu E, McLaren DG, Fitzgerald ME, Bendlin BB, Zoccatelli G, Alessandrini F, Pizzini FB, Ricciardi GK, Beltramello A, Johnson SC, Frisoni GB (2010) Microstruc-tural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer's disease. J Alzheimers Dis 19, 963-976.
54. Dubois B, Feldman HH, Jacova C, Cummings JL, DeKosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer's disease: A new lexicon. Lancet Neurol 9, 1118-1127.
55. Motter R, Vigo-Pelfrey C, Kholodenko D, Barbour R, Johnson-Wood K, Galasko D, Chang L, Miller B, Clark C, Green R, Olson D, Southwick P, Wolfert R, Munroe B, Lieberburg I, Seubert P, Schenk D (1995) Reduction of fj-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 38, 643-648.
56. Vandermeeren M, Mercken M, Vanmechelen E, Six J, Van de Voorde A, Martin J-J, Cras P (1993) Detection of proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. J Neurochem 61, 1828-1834. (Pubitemid 23317209)
57. Coleman RE (2005) Positron emission tomography diagnosis of Alzheimer's disease. Neuroimaging Clin N Am 15, 837-846. (Pubitemid 43162381)
58. Bird TDM (2005) Genetic aspects of Alzheimer disease. Genet Med 10, 231-239.
59. Pitkanen A, Laakso M, Kalviainen R, Partanen K, Vainio P, Lehtovirta M, Riekkinen P, Soininen H (1996) Severity of hippocampal atrophy correlates with the prolongation of MRI T sub 2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease. Neurology 46, 1724-1730. (Pubitemid 26185801)
60. Convit A, De Leon MJ, Tarshish C, De Santi S, Tsui W, Rusinek H, George A (1997) Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol Aging 18, 131-138. (Pubitemid 27355930)
61. Kaye JA, Swihart T, Howieson D, Dame A, Moore MM, Karnos T, Camicioli R, Ball M, Oken B, Sexton G (1997) Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology 48, 1297-1304. (Pubitemid 27240552)
62. Mori E, Yoneda Y, Yamashita H, Hirono N, Ikeda M, Yamadori A (1997) Medial temporal structures relate to memory impairment in Alzheimer's disease: An MRI volumetric study. J Neurol Neurosurg Psychiatry 63, 214-221. (Pubitemid 27388972)
63. Jack CRJr, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Kokmen E (1998) Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology 51, 993-999. (Pubitemid 28473390)
64. Juottonen K, Laakso MP, Insausti R, Lehtovirta M, Pitkänen A, Partanen K, Soininen H (1998) Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease. Neurobiol Aging 19, 15-22. (Pubitemid 28169839)
65. Krasuski JS, Alexander GE, Horwitz B, Daly EM, Murphy DG, Rapoport SI, Schapiro MB (1998) Volumes of medial temporal lobe structuresinpatientswith Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry 43, 60-68. (Pubitemid 28059073)
66. Laakso MP, Soininen H, Partanen K, Lehtovirta M, Hal-likainen M, Hänninen T, Helkala EL, Vainio P, Riekkinen PJ (1998) MRI of the hippocampus in Alzheimer's disease: Sensitivity, specificity, and analysis of the incorrectly classified subjects. Neurobiol Aging 19, 23-31. (Pubitemid 28167791)
67. Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT (2000) A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: Magnetic resonance imaging volumetric study. Dement Geriatr Cogn Disord 12, 198-205.
68. De Toledo-Morrell L, Goncharova I, Dickerson B, Wilson RS, Bennett DA (2000) From healthy aging to early Alzheimer's disease: In vivo detection of entorhinal cortex atrophy. Ann N Y Acad Sci 911, 240-253. (Pubitemid 30462086)
69. Laakso MP, Frisoni GB, Könönen M, Mikkonen M, Bel-tramello A, Geroldi C, Bianchetti A, Trabucchi M, Soininen H, Aronen HJ (2000) Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: A mor-phometric MRI study. Biol Psychiatry 47, 1056-1063. (Pubitemid 30336214)
70. Xu Y, Jack CR, O'Brien PC, Kokmen E, Smith GE, Ivnik RJ, Boeve BF, Tangalos RG, Petersen RC (2000) Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology 54, 1760-1767. (Pubitemid 30428402)
71. De Santi S, de Leon MJ, Rusinek H, Convit A, Tarshish CY, Roche A, Tsui WH, Kandil E, Boppana M, Daisley K, Wang GJ, Schlyer D, Fowler J (2001) Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging 22, 529-539. (Pubitemid 32607736)
72. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW (2001) Magnetic resonance imaging of the entorhi-nal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry 71, 441-447. (Pubitemid 32906865)
73. Goncharova II, Dickerson BC, Stoub TR, deToledo-Morrell L (2001) MRI of human entorhinal cortex: A reliable protocol for volumetric measurement. Neurobiol Aging 22, 737-745. (Pubitemid 33055613)
74. Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG, Angerhôfer S, Hojjatoleslami A, Hensel A, Arendt T, Gertz HJ (2001) Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiol Aging 22, 177-186. (Pubitemid 32162966)
75. Bottino CM, Castro CC, Gomes RL, Buchpiguel CA, Marchetti RL, Neto MR (2002) Volumetric MRI measurements can differentiate Alzheimer's disease, mild cognitive impairment, and normal aging. Int Psychogeriatr 14, 59-72. (Pubitemid 34625564)
76. Hsu Y-Y, Schuff N, Du A-T, Mark K, Zhu X, Hardin D, Weiner MW (2002) Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. J Magn Reson Imaging 16, 305-310. (Pubitemid 34920430)
77. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS (2002) MRI measures of entorhinal cortex versus hippocampus in preclinical AD. Neurology 58, 1188-1196. (Pubitemid 34411862)
78. Mega MS, Small GW, Xu ML, Felix J, Manese M, Tran NP, Dailey JI, Ercoli LM, Bookheimer SY, Toga AW (2002) Hip-pocampal atrophy in persons with age-associated memory impairment: Volumetry within a common space. Psychosom Med 64, 487-492. (Pubitemid 34556414)
79. Pantel J, Häger DR, Kratz B, Minnemann E, Martin M, Schad LR, Essig M, Schröder J (2002) Strukturelle zerebrale Veranderungen bei Probanden mit leichter kognitiver Beein-trachtigung Eine MR-volumetrische Studie. Der Nervenarzt 73, 845-850. (Pubitemid 36062320)
80. Du AT, Schuff N, Zhu XP, Jagust WJ, Miller BL, Reed BR, Kramer JH, Mungas D, Yaffe K, Chui HC, Weiner MW (2003) Atrophy rates of entorhinal cortex in AD and normal aging. Neurology 60, 481-486. (Pubitemid 36188246)
81. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW (2004) Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology 62, 422-427. (Pubitemid 38200854)
82. Testa C, Laakso MP, Sabattoli F, Rossi R, Beltramello A, Soininen H, Frisoni GB (2004) A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease. J Magn Reson Imaging 19, 274-282. (Pubitemid 38294766)
83. Bastos-Leite AJ, van Waesberghe JH, Oen AL, van der Flier WM, Scheltens P, Barkhof F (2006) Hippocampal sul-cus width and cavities: Comparison between patients with Alzheimer disease and nondemented elderly subjects. AJNR Am J Neuroradiol 27, 2141-2145. (Pubitemid 44788646)
84. Kalus P, Slotboom J, Gallinat Jr, Mahlberg R, Cattapan-Ludewig K, Wiest R, Nyffeler T, Buri C, Federspiel A, Kunz D, Schroth G, Kiefer C (2006) Examining the gateway to the limbic system with diffusion tensor imaging: The perforant pathway in dementia. Neuroimage 30, 713-720.
85. Teipel S, Pruessner J, Faltraco F, Born C, Rocha-Unold M, Evans A, Möller HJ, Hampel H (2006) Comprehensive dissection of the medial temporal lobe in AD: Measurement of hippocampus, amygdala, entorhinal, perirhinal and parahip-pocampal cortices using MRI. J Neurol 253, 794-800. (Pubitemid 43982517)
86. Uotani C, Sugimori K, Kobayashi K (2006) Association of minimal thickness of the medial temporal lobe with hippocampal volume, maximal and minimal hippocampal length: Volumetric approach with horizontal magnetic resonance imaging scans for evaluation of a diagnostic marker for neuroimaging of Alzheimer's disease. Psychiatry Clin Neurosci 60, 319-326. (Pubitemid 43736396)
87. van de Pol LA, Hensel A, van der Flier WM, Visser PJ, Pijnenburg YAL, Barkhof F, Gertz HJ, Scheltens P (2006) Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer disease. J Neurol Neu-rosurg Psychiatry 77, 439-442.
88. Barnes J, Godbolt AK, Frost C, Boyes RG, Jones BF, Scahill RI, Rossor MN, Fox NC (2007) Atrophy rates of the cin-gulate gyrus and hippocampus in AD and FTLD. Neurobiol Aging 28, 20-28. (Pubitemid 44791643)
89. Meyer JS, Huang J, Chowdhury MH (2007) MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular andParkinson-Lewy bodydementias.JNeurol Sci257, 97-104. (Pubitemid 46856488)
90. Ridha BH, Barnes J, van de Pol LA, Schott JM, Boyes RG, Siddique MM, Rossor MN, Scheltens P, Fox NC (2007) Application of automated medial temporal lobe atrophy scale to Alzheimer disease. Arch Neurol 64, 849-854. (Pubitemid 46919840)
91. Slavin MJ, Sandstrom CK, Tran T-TT, Doraiswamy PM, Petrella JR (2007) Hippocampal volume and the mini-mental state examination in the diagnosis of amnestic mild cognitive impairment. Am J Roentgenol 188, 1404-1410. (Pubitemid 46668527)
92. Colliot O, Chételat G, Chupin M, Desgranges B, Magnin B, Benali H, Dubois B, Garnero L, Eustache F, Lehéricy S (2008) Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus1. Radiology 248, 194-201.
93. Delano-Wood L, Bondi MW, Jak AJ, Horne NR, Schweins-burg BC, Frank LR, Wierenga CE, Delis DC, Theilmann RJ, Salmon DP (2008) Stroke risk modifies regional white matter differences in mild cognitive impairment. Neurobiol Aging 31, 1721-1731.
94. Duara R, Loewenstein DA, Potter E, Appel J, Greig MT, Urs R, Shen Q, Raj A, Small B, Barker W, Schofield E, Wu Y, Potter H (2008) Medial temporal lobe atrophy on MRI scans and the diagnosisof Alzheimer disease. Neurology 71, 1986-1992.
95. Kenny ER, Burton EJ, O'Brien JT (2008) A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementia. Dement Geriatr Cogn Disord 26, 218-225.
96. Appel J, Potter E, Bhatia N, Shen Q, Zhao W, Greig MT, Raj A, Barker WW, Potter H, Schofield E, Wu Y, Loewenstein DA, Duara R (2009) Association of white matter hyperin-tensity measurements on brain mr imaging with cognitive status, medial temporal atrophy, and cardiovascular risk factors. Am J Neuroradiol 30, 1870-1876.
97. Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Zhu W, Wang L, Yuan Y, Qian Y (2009) Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett 450, 85-89.
98. Cho H, Kwon J-H, Seo H-J (2009) Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale. Arch Gerontol Geriatr 48, 415-418.
99. Feczko E, Augustinack JC, Fischl B, Dickerson BC (2009) An MRI-based method for measuring volume, thickness and surface area of entorhinal, perirhinal, and posterior parahip-pocampal cortex. Neurobiol Aging 30, 420-431.
100. Ferrarini L, Frisoni GB, Pievani M, Reiber JHC, Ganzola R, Milles J (2009) Morphological hippocampal markers for automated detection of Alzheimer's disease and mild cognitive impairment converters in magnetic resonance images. J Alzheimers Dis 17, 643-659.
101. Henneman WJP, Sluimer JD, Barnes J, van der Flier WM, Sluimer IC, Fox NC, Scheltens P, Vrenken H, Barkhof F (2009) Hippocampal atrophy rates in Alzheimer disease: Added value over whole brain volume measures. Neurology 72, 999-1007.
102. Henneman WJP, Vrenken H, Barnes J, Sluimer IC, Ver-wey NA, Blankenstein MA, Klein M, Fox NC, Scheltens P, Barkhof F, van der Flier WM (2009) Baseline CSF p-tau levels independently predict progressionofhippocampal atrophy in Alzheimer disease. Neurology 73, 935-940.
103. Hyun C, Jee-Hyun K, Hyun-Jin S (2009) Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale. Arch Gerontol Geriatr 48, 415-418.
104. Jauhiainen AM, PihlajamäkiM, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H (2009) Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment. Hippocampus 19, 166-175.
105. Lee DY, Fletcher E, Martinez O, Ortega M, Zozulya N, Kim J, Tran J, Buonocore M, Carmichael O, DeCarli C (2009) Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology 73, 1722-1728.
106. Loewenstein DA, Acevedo A, Potter E, Schinka JA, Raj A, Greig MT, Agron J, Barker WW, Wu Y, Small B, Schofield E, Duara R (2009) Severity of medial temporal atrophy and amnestic mild cognitive impairment: Selecting type and number of memory tests. Am J Geriatr Psychiatry 17, 1050-1058.
107. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM (2009) Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.Hum Brain Mapp30, 2766-2788.
108. Rogalski EJ, Murphy CM, deToledo-Morrell L, Shah RC, Moseley ME, Bammer R, Stebbins GT (2009) Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: A diffusion tensor imaging study. Behav Neurol 21, 51-61.
109. Bird CM, Chan D, Hartley T, Pijnenburg YA, Rossor MN, Burgess N (2010) Topographical short-term memory differentiates Alzheimer's disease from frontotemporal lobar degeneration. Hippocampus 20, 1154-1169.
110. Bouwman FH, Verwey NA, Klein M, Kok A, Blankenstein MA, Sluimer JD, Barkhof F, van der Flier WM, Schel-tens P (2010) New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population. Dement Geriatr Cogn Disord 30, 1-7.
111. Cherubini A, Péran P, Spoletini I, Di Paola M, Di Iulio F, Hagberg GE, Sancesario G, Gianni W, Bossù P, Caltagirone C, Sabatini U, Spalletta G (2010) Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer'sdisease patients.J Alzheimers Dis19, 1273-1282.
112. Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B, Alzheimer's Disease Neuroimaging I (2010) Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One 5, e12853-e12853.
113. Jhoo JH, Lee DY, Choo IH, Seo EH, Oh JS, Lee JS, Lee DS, Kim SG, Youn JC, Kim KW, Woo JI (2010) Discrimination of normal aging, MCI and AD with multimodal imaging measures on the medial temporal lobe. Psychiatry Res 183, 237-243.
114. Johnson DK, Barrow W, Anderson R, Harsha A, Honea R, Brooks WM, Burns JM (2010) Diagnostic utility of cerebral white matter integrity in early Alzheimer's disease. Int J Neurosci 120, 544-550.
115. Lehmann M, Douiri A, Kim LG, Modat M, Chan D, Ourselin S, Barnes J, Fox NC (2010) Atrophy patterns in Alzheimer's disease and semantic dementia: A comparison of Free Surfer and manual volumetric measurements. Neuroimage 49, 2264-2274.
116. Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H, Add Neuro Med Consortium (2010) Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging 31, 1375-1385.
117. Luckhaus C, Jänner M, Cohnen M, Flüss MO, Teipel SJ, Grothe M, Hampel H, Kornhuber J, Rüther E, Peters O, Supprian T, Gaebel W, Mödder U, Wittsack HJ (2010) A novel MRI-biomarker candidate for Alzheimer's disease composed of regional brain volume and perfusion variables. Eur J Neurol 17, 1437-1444.
118. Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW (2010) Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 31, 1339-1347.
119. Pengas G, Hodges JR, Watson P, Nestor PJ (2010) Focal posterior cingulate atrophy in incipient Alzheimer's disease. Neurobiol Aging 31, 25-33.
120. Ryu SY, Kwon MJ, Lee SB, Yang DW, Kim TW, Song IU, Yang PS, Kim HJ, Lee AY (2010) Measurement of pre-cuneal and hippocampal volumes using magnetic resonance volumetry in Alzheimer's disease. J Clin Neurol 6, 196-203.
121. Sanchez-Benavides G, Gomez-Anson B, Molinuevo JL, Blesa R, Monte GC, Buschke H, Pena-Casanova J (2010) Medial temporal lobe correlates of memory screening measures in normal aging, MCI, and AD. J Geriatr Psychiatry Neurol 23, 100-108.
122. Schott JM, Bartlett JW, Barnes J, Leung KK, Ourselin S, Fox NC (2010) Reduced sample sizes for atrophy outcomes in Alzheimer's disease trials: Baseline adjustment. Neurobiol Aging 31, 1452-1462.e1452.
123. Westman E, Wahlund L-O, Foy C, Poppe M, Cooper A, Murphy D, Spenger C, Lovestone S, Simmons A (2010) Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls. J Alzheimers Dis 22, 171-181.
124. Yakushev I, Müller MJ, Lorscheider M, Schermuly I, Weibrich C, Dellani PR, Hammers A, Stoeter P, Fell-giebel A (2010) Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease. Neuropsychologia 48, 1447-1453.
125. Zarei M, Patenaude B, Damoiseaux J, Morgese C, Smith S, Matthews PM, Barkhof F, Rombouts S, Sanz-Arigita E, Jenkinson M (2010) Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease. Neuroimage 49, 1-8.
126. Echavarri C, Aalten P, Uylings H, Jacobs H, Visser P, Gronenschild E, Verhey F, Burgmans S (2011) Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Struct Funct 215, 265-271.
127. Prestia A, Boccardi M, Galluzzi S, Cavedo E, Adorni A, Soricelli A, Bonetti M, Geroldi C, Giannakopoulos P, Thompson P, Frisoni G (2011) Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia. Psychiatry Res 192, 77-83.
128. Zhang Y-Z, Chang C, Wei X-e, Fu J-L, Li W-B (2011) Comparison of diffusion tensor image study in association fiber tracts among normal, amnestic mild cognitive impairment, and Alzheimer's patients. Neurol India 59, 168-173.
129. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease. Neurology 34, 939-939.
130. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B (2001) Current concepts in mild cognitive impairment. Arch Neurol 58, 1985-1992. (Pubitemid 33143977)
131. Rose SE, Chen F, Chalk JB, Zelaya FO, Strugnell WE, Benson M, Semple J, Doddrell DM (2000) Loss of connectivity in Alzheimer's disease: An evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry 69, 528-530.
132. Bozzali M, Falini A, Franceschi M, Cercignani M, Zuffi M, Scotti G, Comi G, Filippi M (2002) White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging. J Neurol Neurosurg Psychiatry 72, 742-746. (Pubitemid 34557017)
133. Stahl R, Dietrich O, Teipel S, Hampel H, Reiser MF, Schoenberg SO (2003) Diffusion tensor imaging zur Erfassung axonaler Degeneration bei Morbus Alzheimer. Der Radiologe 43, 566-575. (Pubitemid 36966296)
134. Fellgiebel A, Wille P, Müller MJ, Winterer G, Scheurich A, Vucurevic G, Schmidt LG, Stoeter P (2004) Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: A diffusion tensor imaging study. Dement Geriatr Cogn Disord 18, 101-108. (Pubitemid 38822746)
135. Head D, Buckner RL, Shimony JS, Williams LE, Akbudak E, Conturo TE, McAvoy M, Morris JC, Snyder AZ (2004) Differential Vulnerability of anterior white matter in nonde-mented aging with minimal acceleration in dementia of the Alzheimer type: Evidence from diffusion tensor imaging. Cereb Cortex 14, 410-423. (Pubitemid 38506972)
136. Choi SJ, Lim KO, Monteiro I, Reisberg B (2005) Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: A preliminary study. J Geriatr Psychiatry Neurol 18, 12-19. (Pubitemid 40313186)
137. Fellgiebel A, Müller MJ, Wille P, Dellani PR, Scheurich A, Schmidt LG, Stoeter P (2005) Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiol Aging 26, 1193-1198. (Pubitemid 40726012)
138. Duan J-H, Wang H-Q, Xu J, Lin X, Chen S-Q, Kang Z, Yao Z-B (2006) White matter damage of patients with Alzheimer's disease correlated with the decreased cognitive function. Surg Radiol Anat 28, 150-156.
139. Naggara O, Oppenheim C, Rieu D, Raoux N, Rodrigo S, Dalla Barba G, Meder J-F (2006) Diffusion tensor imaging in early Alzheimer's disease. Psychiatry Res 146, 243-249. (Pubitemid 44218939)
140. Rose SE, McMahon KL, Janke AL, O'Dowd B, de Zubicaray G, Strudwick MW, Chalk JB (2006) Diffusion indices on magnetic resonance imaging and neuropsycho-logical performance in amnestic mild cognitive impairment. J Neurol Neurosurg Psychiatry 77, 1122-1128. (Pubitemid 44453245)
141. Taoka T, Iwasaki S, Sakamoto M, Nakagawa H, Fukusumi A, Myochin K, Hirohashi S, Hoshida T, Kichikawa K (2006) Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: Evaluation of the "Tract of Interest" by diffusion tensor tractography. Am J Neuroradiol 27, 1040-1045. (Pubitemid 44897683)
142. Chen S-q, Kang Z, Hu X-q, Hu B, Zou Y (2007) Diffusion tensor imaging of the brain in patients with Alzheimer's disease and cerebrovascular lesions. J Zhejiang Univ Sci B 8, 242-247.
143. Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT (2007) Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. Psychiatry Res 155, 135-145. (Pubitemid 46874916)
144. Huang J, Auchus AP (2007) Diffusion tensorimagingofnor-mal appearing white matter and its correlation with cognitive functioning in mild cognitive impairment and Alzheimer's disease. Ann N Y Acad Sci 1097, 259-264. (Pubitemid 47084896)
145. Stahl R, Dietrich O, Teipel SJ, Hampel H, Reiser MF, Schoenberg SO (2007) White matter damage in Alzheimer disease and mild cognitive impairment: Assessment with diffusion-tensor MR imaging and parallel imaging techniques. Radiology 243, 483-492. (Pubitemid 46649705)
146. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, Mueller S, Du AT, Kramer JH, Yaffe K, Chui H, Jagust WJ, Miller BL, Weiner MW (2007) Diffusion tensor imaging of cingulumfibersinmild cognitive impairment and Alzheimer disease. Neurology 68, 13-19. (Pubitemid 46058544)
147. Cho H, Yang DW, Shon YM, Kim BS, Kim YI, Choi YB, Lee KS, Shim YS, Yoon B, Kim W, Ahn KJ (2008) Abnormal integrity of corticocortical tracts in mild cognitive impairment: A diffusion tensor imaging study. J Korean Med Sci 23, 477-483.
148. Ding B, Chen KM, Ling HW, Zhang H, Chai WM, Li X, Wang T (2008) Diffusion tensor imaging correlates with proton magnetic resonance spectroscopy in posterior cin-gulate region of patients with Alzheimer's disease. Dement Geriatr Cogn Disord 25, 218-225. (Pubitemid 351363885)
149. Fujie S, Namiki C, Nishi H, Yamada M, Miyata J, Sakata D, Sawamoto N, Fukuyama H, Hayashi T, Murai T (2008) The role ofthe uncinate fasciculusin memory and emotional recognition in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord 26, 432-439.
150. Parente D, Gasparetto E, da Cruz LCH, Domingues RC, Baptista AC, Carvalho ACP, Domingues RC (2008) Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease. Am J Radiol 190, 1369-1374. (Pubitemid 351684937)
151. Shim YS, Yoon B, Shon Y-M, Ahn K-J, Yang D-W (2008) Difference of the hippocampal and white matter microal-terations in MCI patients according to the severity of subcortical vascular changes: Neuropsychological correlates of diffusion tensor imaging. Clin Neurol Neurosurg 110, 552-561.
152. Ukmar M, Makuc E, Onor M, Garbin G, Trevisiol M, Cova M (2008) Evaluation of white matter damage in patients with Alzheimer's disease and in patients with mild cognitive impairment by using diffusion tensor imaging. La Radiologia Medica 113, 915-922.
153. Yasmin H, Nakata Y, Aoki S, Abe O, Sato N, Nemoto K, Arima K, Furuta N, Uno M, Hirai S, Masutani Y, Ohtomo K (2008) Diffusion abnormalities of the uncinate fasciculus in Alzheimer's disease: Diffusion tensor tract-specific analysis using a new method to measure the core of the tract. Neuroradiology 50, 293-299.
154. Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Yuan Y, Qian Y, Jia J (2009) Abnormal integrity of association fiber tracts in amnestic mild cognitive impairment. J Neurol Sci 278, 102-106.
155. Chen T-F, Chen Y-F, Cheng T-W, Hua M-S, Liu H-M, Chiu M-J (2009) Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease. Hum Brain Mapp 30, 3826-3836.
156. Kiuchi K, Morikawa M, Taoka T, Nagashima T, Yamauchi T, Makinodan M, Norimoto K, Hashimoto K, Kosaka J, Inoue Y, Inoue M, Kichikawa K, Kishimoto T (2009) Abnormalities of the uncinate fasciculus and posterior cin-gulate fasciculus in mild cognitive impairment and early Alzheimer's disease: A diffusion tensor tractography study. Brain Res 1287, 184-191.
157. Liu Y, Spulber G, Lehtimäki KK, Könönen M, Hallikainen I, GröhnH, Kivipelto M, Hallikainen M, Vanninen R, Soininen H (2012) Diffusion tensor imaging and tract-based spatial statistics in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 32, 1558-1571.
158. Mielke MM, Kozauer NA, Chan KCG, George M, Toroney J, Zerrate M, Bandeen-Roche K, Wang MC, van Zijl P, Pekar JJ, Mori S, Lyketsos CG, Albert M (2009) Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neuroimage 46, 47-55.
159. Nakata Y, Sato N, Nemoto K, Abe O, Shikakura S, Arima K, Furuta N, Uno M, Hirai S, Masutani Y, Ohtomo K, Barkovich AJ, Aoki S (2009) Diffusion abnormality in the posterior cingulum and hippocampal volume: Correlation with disease progression in Alzheimer's disease. Magn Reson Imaging 27, 347-354.
160. Stricker NH, Schweinsburg BC, Delano-Wood L, Wierenga CE, Bangen KJ, Haaland KY, Frank LR, Salmon DP, Bondi MW (2009) Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis. Neuroimage 45, 10-16.
161. Zarei M, Damoiseaux JS, Morgese C, Beckmann CF, Smith SM, Matthews PM, Scheltens P, Rombouts SARB, Barkhof F (2009) Regional white matter integrity differentiates between vascular dementia and Alzheimer disease. Stroke 40, 773-779.
162. Catheline G, Periot O, Amirault M, Braun M, Dartigues J-F, Auriacombe S, Allard M (2010) Distinctive alterations of the cingulum bundle during aging and Alzheimer's disease. Neurobiol Aging 31, 1582-1592.
163. Hong YJ, Yoon B, Shim YS, Cho AH, Lim SC, Ahn KJ, Yang DW (2010) Differences in microstructural alterations of the hippocampus in Alzheimer disease and idiopathic normal pressure hydrocephalus: A diffusion tensor imaging study. Am J Neuroradiol 31, 1867-1872.
164. Kantarci K, Avula R, Senjem ML, Samikoglu AR, Zhang B, Weigand SD, Przybelski SA, Edmonson HA, Vemuri P, Knopman DS, Ferman TJ, Boeve BF, Petersen RC, Jack CR (2010) Dementia with Lewy bodies and Alzheimer disease: Neurodegenerative patterns characterized by DTI. Neurology 74, 1814-1821.
165. Pievani M, Agosta F, Pagani E, Canu E, Sala S, Absinta M, Geroldi C, Ganzola R, Frisoni GB, Filippi M (2010) Assessment of white matter tract damage in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 31, 1862-1875.
166. Pitel A-L, Chanraud S, Sullivan EV, Pfefferbaum A (2010) Callosal microstructural abnormalities in Alzheimer's disease and alcoholism: Same phenotype, different mechanisms. Psychiatry Res 184, 49-56.
167. Scola E, Bozzali M, Agosta F, Magnani G, Franceschi M, Sormani MP, Cercignani M, Pagani E, Falautano M, Filippi M, Falini A (2010) A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up. J Neurol Neurosurg Psychiatry 81, 798-805.
168. Sjöbeck M, Elfgren C, Larsson E-M, Brockstedt S, Lätt J, Englund E, Passant U (2010) Alzheimer's disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI). Arch Gerontol Geriatr 50, 260-266.
169. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, De Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, Van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment-beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256, 240-246. (Pubitemid 39222993)
170. Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, Sano M, Bieliauskas L, Geldmacher D, Clark C, Thal LJ (1997) Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the Alzheimer's disease assessment scale that broaden its scope, Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS. Alzheimer Dis Assoc Disord 11 (2) S13-S21.