Modulation of inflammatory response in mice with severe autoimmune disease by thymic peptide thymulin and an inhibitor of NF-kappaB signalling

International Immunopharmacology

Volumn 25, Issue 2, 2015, Pages 260-266

  Lunin, S M ^a   Khrenov, M O ^a   Novoselova, T V ^a   Parfenyuk, S B ^a   Glushkova, O V ^a   Fesenko, E E ^a   Novoselova, E G ^a  

^a RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

Author keywords

Autoimmune diseases; IKK inhibitor XII; Interferon gamma; Interleukin 17; NF kappaB; Thymulin

Indexed keywords

GAMMA INTERFERON; HEAT SHOCK PROTEIN 72; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; STRESS ACTIVATED PROTEIN KINASE; THYMULIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE SEVERITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IMMUNIZATION; IMMUNOMODULATION; LETHALITY; LIFESPAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOLOGY; LYMPHOCYTE; SPLEEN;

ANIMALS; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HSP72 HEAT-SHOCK PROTEINS; LYMPHOCYTES; MALE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; SIGNAL TRANSDUCTION; SPLEEN; TH1 CELLS; TH17 CELLS; THYMIC FACTOR, CIRCULATING;

EID: 84923653870     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.01.021     Document Type: Article

References (29)

1. S.M. Lunin, O.V. Glushkova, M.O. Khrenov, T.V. Novoselova, S.B. Parfenyuk, and E.E. Fesenko Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis Immunobiology 218 3 2013 402 407
2. H.F. McFarland, and R. Martin Multiple sclerosis: a complicated picture of autoimmunity Nat Immunol 8 2007 913 919
3. C.S. Raine Multiple Sclerosis: Clinical and Pathogenetic Basis H.F. McFarland, W.W. Tourtellotte, 1997 Chapman and Hall London 243 286
4. C.F. Brereton, C.E. Sutton, S.J. Lalor, E.C. Lavelle, and K.H. Mills Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease J Immunol 183 3 2009 1715 1723
5. M.G. Mujtaba, L.O. Flowers, C.B. Patel, R.A. Patel, M.I. Haider, and H.M. Johnson Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing/remitting form J Immunol 75 8 2005 5077 5086
6. W. Savino, and M. Dardenne Neuroendocrine control of thymus physiology Endocr Rev 21 2000 412 443
7. M. Santos, T.H. Coelho, and A.L. Moreira Immunomodulatory role of thymulin in lung diseases Expert Opin Ther Targets 14 2009 1 11
8. P.C. Reggiani, J.I. Schwerdt, G.M. Cónsole, E. Roggero, M. Dardenne, and R.G. Goya Therapeutic potential of the thymic peptide thymulin Curr Pharm Des 20 2014 4690 4696
9. S.M. Lunin, and E.G. Novoselova Thymus hormones as prospective anti-inflammatory agents Expert Opin Ther Targets 14 8 2010 775 786
10. N. Saitoh, A. Awaya, and A. Sakudo Serum thymic factor prevents LPS-induced pancreatic cell damage in mice via up-regulation of Bcl-2 expression in pancreas Microbiol Immunol 48 2004 629 638
11. A.L. Da Silva, S.V. Martini, S.C. Abreu, C.D. Samary, B.L. Diaz, and S. Fernezlian DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma J Control Release 180 2014 125 133
12. T.C. Henriques, S.M. Oliveira, and R.S. Moura Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway Endocrinology 149 2008 4367 4373
13. M. Mizutani, M. El-Fotoh, M. Mori, K. Ono, K. Doi, and A. Awaya In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice Arch Virol 141 1996 73 83
14. M. Dardenne, N. Saade, and B. Safieh-Garabedian Role of thymulin or its analogue as a new analgesic molecule Ann NY Acad Sci 1088 2006 153 163
15. S.M. Lunin, M.O. Khrenov, T.V. Novoselova, S.B. Parfenyuk, and E.G. Novoselova Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice Immunol Invest 37 2008 858 870
16. H. Ogura, M. Murakami, Y. Okuyama, M. Tsuruoka, C. Kitabayashi, and M. Kanamoto Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction Immunity 29 4 2008 628 636
17. J.A. Christopher, B.G. Avitabile, and P. Bamborough The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases Bioorg Med Chem Lett 17 2007 3972 3977
18. F. Jadidi-Niaragh, and A. Mirshafiey Th17 cell, the new player of inflammatory process in multiple sclerosis Scand J Immunol 74 2011 1 13
19. D. Miljković, Z. Stanojević, M. Momcilović, F. Odoardi, A. Flügel, and M. Mostarica-Stojković CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats Immunobiology 216 9 2011 979 987
20. S.J. Pittock, and C.F. Lucchinetti The pathology of MS: new insights and potential clinical applications Neurologist 13 2007 45 56
21. Y. Sonobe, S. Jin, J. Wang, J. Kawanokuchi, H. Takeuchi, and T. Mizuno Chronological changes of CD4(+) and CD8(+) T cell subsets in the experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis Tohoku J Exp Med 213 2007 329 339
22. J.S. Tzartos, M.A. Friese, M.J. Craner, J. Palace, J. Newcombe, and M.M. Esiri Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis Am J Pathol 172 2008 146 155
23. L. Zhou, I.I. Ivanov, R. Spolski, R. Min, K. Shenderov, and T. Egawa IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 2007 967 974
24. T. Korn, E. Bettelli, M. Oukka, and V.K. Kuchroo IL-17 and Th17 Cells Annu Rev Immunol 27 2009 485 517
25. I. Hwang, D. Ha, G. Ahn, E. Park, H. Joo, and Y. Jee Experimental autoimmune encephalomyelitis: association with mutual regulation of RelA (p65)/NF-κB and phospho-IκB in the CNS Biochem Biophys Res Commun 411 2 2011 464 470
26. E. Dejardin The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development Biochem Pharmacol 72 9 2006 1161 1179
27. E.G. Novoselova, S.M. Lunin, M.O. Khrenov, D.A. Cherenkov, T.V. Novoselova, and E.A. Lysenko Effect of thymopentin on the production of cytokines, heat shock proteins, and NF-kappa B signaling proteins Biol Bull 35 4 2008 362 367
28. E.G. Novoselova, S.M. Lunin, M.O. Khrenov, T.V. Novoselova, and E.E. Fesenko Involvement of NF-kB transcription factor in the antiinflammatory activity of thymic peptides Dokl Biol Sci 428 2009 484 486
29. S.M. Lunin, O.V. Glushkova, M.O. Khrenov, S.B. Parfenyuk, T.V. Novoselova, and E.E. Fesenko Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades Expert Opin Ther Targets 15 12 2011 1337 1346