Role of thymulin or its analogue as a new analgesic molecule

Annals of the New York Academy of Sciences

Volumn 1088, Issue , 2006, Pages 153-163

  Dardenne, Mireille ^a   Saade, Nayef ^b   Safieh Garabedian, Bared ^b  

^a CNRS   (France)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Analgesics; Cytokines; Hyperalgesia; Inflammation; PAT (peptide analogue of thymulin); Thymulin; Thymus

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; CYTOKINE; DEXAMETHASONE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 10; LYSYL DEXTRO PROLYLVALINE; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; PEPTIDE DERIVATIVE; PROSTAGLANDIN E2; STEROID; THYMULIN; THYMULIN DERIVATIVE; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; IMMUNOLOGIC FACTOR;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; ENCEPHALITIS; ENZYME ACTIVATION; FEVER; GENE EXPRESSION; HYPERALGESIA; ILLNESS BEHAVIOR; LOCOMOTION; NERVE ENDING; NEUROIMMUNOLOGY; NEUROPROTECTION; NONHUMAN; PAIN; UPREGULATION; ANIMAL; HUMAN; IMMUNOLOGY; REVIEW;

ANALGESICS; ANIMALS; HUMANS; HYPERALGESIA; IMMUNOLOGIC FACTORS; PAIN; THYMIC FACTOR, CIRCULATING;

EID: 34447623547     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1366.006     Document Type: Conference Paper

References (42)

1. BACH, J.F., M. DARDENNE, J.M. PLEAU & J. ROSA. 1977. Biochemical characterization of a serum thymic hormone. Nature 266: 55-56.
2. BACH, J.F. 1983. Thymulin (FTS-Zn). Clin. Immunol. Allergy 3: 133-156.
3. DARDENNE, M., J.M. PLEAU, B. NABARRA, et al. 1982. Contribution of zinc and other metals to the biological activity of the serum thymic factor (FTS). Proc. Natl. Acad. Sci. USA 79: 5370-5375.
4. DARDENNE, M., B. SAFIEH-GARABEDIAN & J.M. PLEAU. 2000. Thymic peptides: transmitters between the neuroendocrine and immune system. In Pain and Neuroimmune Interactions. N.E. Saade, A.V. Apkarian & S.J. Jabbur, Eds.: 127-137. Kluwer Academic/Plenum. New York.
5. VON GAUDECKER, B., M.D. KENDALL & M.A. RITTER. 1997. Immuno-electron microscopy of the thymic microenvironment. Micros. Res. Tech. 38: 237-249.
6. SAVINO, W. & M. DARDENNE. 2000. Neuroendocrine control of thymus physiology. Endocrine Rev. 21: 412-443.
7. SAFIEH, B., G.E. VENN, M. RITTER, et al. 1991. Plasma thymulin concentrations in cardiac patients: involvement with the hypothalamo-pituitary-adrenal axis. J. Physiol. (Paris) 438: 50.
8. BUCKINGHAM, J.C., B. SAFIEH-GARABEDIAN, S. SINGH, et al. 1992. Interactions between the hypothalamus-pituitary adrenal axis and the thymus in the rat: a role for corticotrophin in the control of thymulin release. J. Neuroendocrinol. 4: 295-301.
9. BLALOCK, J.E. 1994. The syntax of immune-neuroendocrine communication. Immunol. Today 15: 504-511.
10. SAFIEH-GARABEDIAN, B., S.A. KANAAN, R.H. JALAKHIAN, et al. 1997. Hyperalgesia induced by low doses of thymulin injections: possible involvement of prostaglandin E2. J. Neuroimmunol. 73: 162-168.
11. POOLE, S., A.F. BRISTOW, B.B. LORENZETTI, et al. 1992. Peripheral analgesic activities of peptides related to alpha-melanocyte stimulating hormone and interleukin-1β193-195. Br. J. Pharmacol. 106: 489-492.
12. SAFIEH-GARABEDIAN, B., S.A. KANAAN, J.J. HADDAD, et al. 1997. Involvement of interleukin 1β, nerve growth factor and prostaglandin-E2 in endotoxin induced localized inflammatory hyperalgesia. Br. J. Pharmacol. 121: 1619-1626.
13. FERREIRA, S.H., B.B. LORENZETTI, A.F. BRISTOW & S. POOLE. 1988. Interleukin-1 as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334: 698-700.
14. VANE, J.R., J.A. MITCHELL, I. APPLETON, et al. 1994. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA 91: 2046-2050.
15. WOOLF, C.J., B. SAFIEH-GARABEDIAN, Q.P. MA, et al. 1994. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 62: 327-331.
16. CUNHA, F.Q., S. POOE, B.B. LORENZETTI & S.H. FERREIRA. 1992. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107: 660-664.
17. SAFIEH-GARABEDIAN, B., M. DARDENNE, S.A. KANAAN, et al. 2000. The role of cytokines and prostaglandin-E2 in thymulin induced hyperalgesia. Neuropharmacology 39: 1653-1661.
18. SAADE, N.E., S.C. MAJOR, S.J. JABBUR, et al., 1998. Involvement of capsaicin sensitive primary afferents in thymulin-induced hyperalgesia. J. Neuroimmunol. 91: 171-179.
19. SAADE, N.E., H.F. LAWAND, B. SAFIEH- GARABEDIAN, et al. 1999. Thymulin induces c-Fos expression in the spinal cord of rats, which is reversed by meloxicam and morphine. J. Neuroimmunol. 97: 16-24.
20. SAADE, N.E., P.G. ABOU JAOUDE, F.A. SAADEH, et al. 1997. Fos-like immunoreactivity induced by intraplantar injection of endotoxin and its reduction by morphine. Brain Res. 769: 57-65.
21. MAIER, S.F., E.P. WIERTELAK, L. GOEHLER, et al., 1993. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res. 623: 321-325.
22. KONSMAN, J.P., P. PARNET & P. DANTZER. 2002. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 25: 154-159.
23. KANAAN, S.A., N.E. SAADE, J.J. HADDAD, et al., 1996. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model of inflammatory pain. Pain 66: 373-379.
24. KANAAN, S.A., S. POOLE, N.E. SAADE, et al., 1998. Interleukin-10 reduces the endotoxin induced hyperalgesia in mice. J. Neuroimmunol. 86: 142-150.
25. SAFIEH-GARABEDIAN, B., S.A. KANAAN, R.H. JALAKHIAN, et al., 1997. Involvement of interleukin-1β, nerve growth factor, and prostaglandin-E2 in the hyperalgesia induced by intraplantar injections of lowdoses of thymulin. Brain Behav. Immun. 11: 185-200.
26. LEWIN, G.R., A.M. RITTER & L.M. MENDELL. 1993. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J. Neurosci. 13: 2136-2148.
27. WOOLF, C.J., B. SAFIEH-GARABEDIAN, Q.A. MA, et al., 1994. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neurosci. 62: 327-331.
28. SAFIEH-GARABEDIAN, B., R.H. JALAKHIAN, S.J. JABBUR, et al., 1998. Thymulin at high doses reduces endotoxin-induced hyperalgesia by reducing interleukin-1β and nerve growth factor levels in the hind paw of rats. In Pain Mechanisms and Management. A.V. Apkarian & S. Ayrapetian, Eds.: 131-138. Kluwer Academic/ Plenum. New York.
29. PLEAU, J.M., M. DARDENNE, D. BLANOT, et al., 1979. Antagonistic analogue of serum thymic factor (FTS) interacting with FTS cellular receptor. Immunol. Lett. 1: 179-182.
30. DASCOMBE, M.J. & A.S. MILTON. 1979. Study on the possible entry of bacterial endotoxin and prostaglandin E2 into the central nervous system from the blood. Br. J. Pharmacol. 66: 565-572.
31. SAADE, N.E., S.F. ATWEH, S.J. JABBUR, et al. 2003. A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin. Neuroscience 119: 155-165.
32. SPRANGER, M. & A. FONTANA. 1996. Activation of microglia: a dangerous interlude in immune function in the brain. Neuroscientist 2: 293-299.
33. LEMKE, R., M. HARTLAGE-RUBSAMER & R. SCHLEIBS. 1999. Differential injurydependent glial expression of interleukin-1 alpha, beta, and interleukin-6 in rat brain. Glia 27: 75-87.
34. BALASINGAM, V., T. TEJADA-BERGES, E. WRIGHT, et al. 1994. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J. Neurosci. 14: 846-856.
35. KONSMAN, J.P., P. PARNET & R. DANTZER. 2002. Cytokine-induced sickness behavior: mechanisms and implications. Trends Neurosci. 25: 154-159.
36. POOLE, S., F.Q. CUNHA & S.H. FERREIRA. 2000. Bradykinin, cytokines and inflammatory hyperalgesia. In Pain and Neuroimmune Interactions. N.E. Saade, A.V. Apkarian, S.J. Jabbur, Eds.: 31-45. Kluwer Academic/Plenum Pub. New York.
37. HORI, T., T. OKA, M. HOSOI, et al., 2000. Biphasic modulation of pain by hypothalamic cytokines. In Pain and Neuroscience Interactions. N.E. Saade et al., Eds.: 171-189. Kluwer Academic/Plenum Pub. New York.
38. DINARELLO, C.A., J.A. GELFAND & S.M. WOLFF. 1993. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269: 1829-1835.
39. DE SIMONI, M.G., R. DEL BO, A. DE LUIGI, et al., 1995. Central endotoxin induces different patterns of interleukin (IL)-1β and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology 136: 897-902.
40. TURRIN, N.P., D.A. GAYLE, S.E. ILYIN, et al., 2001. Pro-inflammatory and antiinflammatory cytokine mRNA induction in the periphery and brain following intra-peritoneal administration of bacterial lipopolysaccharide. Brain Res. Bull. 54: 443-453.
41. DANTZER, R.R., M. BLUTHE, J.L. SLAYE, et al., 1998. Cytokines and sickness behavior. Ann. N.Y. Acad. Sci. 840: 586-590.
42. SAFIEH-GARABEDIAN, B., S.A. KANAAN, S.J. JABBUR & N.E. SAADE. 1999. Cytokine mediated or direct effects of thymulin on the nervous system. Neuroimmunomodulation 6: 39-44.