메뉴 건너뛰기




Volumn 20, Issue 29, 2014, Pages 4690-4696

Physiology and therapeutic potential of the thymic peptide thymulin

Author keywords

Anti inflammatory; Gene therapy; Neuroendocrine system; Nude mice; Regulatable promoters; Synthetic gene; Thymulin

Indexed keywords

ADENOVIRUS VECTOR; SYNTHETIC DNA; THYMULIN;

EID: 84906262654     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612820666140130211157     Document Type: Article
Times cited : (11)

References (84)
  • 1
    • 0025900514 scopus 로고
    • The immune-neuroendocrine homeostatic network and ageing
    • Goya RG. The immune-neuroendocrine homeostatic network and ageing. Gerontology 1991; 37: 208-213.
    • (1991) Gerontology , vol.37 , pp. 208-213
    • Goya, R.G.1
  • 2
    • 0011881540 scopus 로고
    • Ontogeny of defined immunity in mammals
    • In: Neuberger A, ELTatum, Eds, New York: Am Elsevier Publishing Co
    • Solomon JB. Ontogeny of defined immunity in mammals. In: Neuberger A, ELTatum, Eds. Foetal and Neonatal Immunology. Frontiers of Biology. New York: Am Elsevier Publishing Co 1971; vol 20, 234-306.
    • (1971) Foetal and Neonatal Immunology. Frontiers of Biology , vol.20 , pp. 234-306
    • Solomon, J.B.1
  • 3
    • 2342530761 scopus 로고
    • The extent of foetal and endocrine autonomy
    • In: Wolstenholme GEW, O'Connor M Eds, Ciba Foundation Symposium. London, Churchill
    • Jost, A. The extent of foetal and endocrine autonomy. In: Wolstenholme GEW, O'Connor M Eds. Foetal Autonomy. Ciba Foundation Symposium. London, Churchill 1969; pp: 79-94.
    • (1969) Foetal Autonomy , pp. 79-94
    • Jost, A.1
  • 5
    • 0016359476 scopus 로고
    • Thymus involvement in female sexual maturation
    • Besedovsky HO, Sorkin E. Thymus involvement in female sexual maturation. Nature 1974; 249: 356-8.
    • (1974) Nature , vol.249 , pp. 356-358
    • Besedovsky, H.O.1    Sorkin, E.2
  • 6
    • 0016731545 scopus 로고
    • Ovarian development in athymic nude mice. I. The size and composition of the follicle population
    • Lintern-Moore S, Pantelouris EM. Ovarian development in athymic nude mice. I. The size and composition of the follicle population. Mech Age Dev 1975; 4: 385-90.
    • (1975) Mech Age Dev , vol.4 , pp. 385-390
    • Lintern-Moore, S.1    Pantelouris, E.M.2
  • 7
    • 0018827156 scopus 로고
    • Effects of neonatal thymectomy on ovarian development and plasma LH, FSH, GH and PRL in the mouse
    • Michael SD, Taguchi O, Nishizuka Y. Effects of neonatal thymectomy on ovarian development and plasma LH, FSH, GH and PRL in the mouse. Biol Reprod 1980; 22: 343-50.
    • (1980) Biol Reprod , vol.22 , pp. 343-350
    • Michael, S.D.1    Taguchi, O.2    Nishizuka, Y.3
  • 8
    • 0015128240 scopus 로고
    • Ovarian dysgenesis induced by neonatal thymectomy in the mouse
    • Nishizuka Y, Sakakura T. Ovarian dysgenesis induced by neonatal thymectomy in the mouse. Endocrinology 1971; 89: 889-93.
    • (1971) Endocrinology , vol.89 , pp. 889-893
    • Nishizuka, Y.1    Sakakura, T.2
  • 9
    • 0016767423 scopus 로고
    • Role of the thymus in programming of neuroendocrine functions
    • Pierpaoli W, Besedovsky HO. Role of the thymus in programming of neuroendocrine functions. Clin Exp Immunol 1975; 20(2): 323-8.
    • (1975) Clin Exp Immunol , vol.20 , Issue.2 , pp. 323-328
    • Pierpaoli, W.1    Besedovsky, H.O.2
  • 10
    • 0017225286 scopus 로고
    • Ovarian development in athymic nude mice. III. The effect of PMSG and oestradiol upon the size and composition of the ovarian follicle population
    • Lintern-Moore S, Pantelouris EM. Ovarian development in athymic nude mice. III. The effect of PMSG and oestradiol upon the size and composition of the ovarian follicle population. Mech Age Dev 1976; 5(1): 33-8.
    • (1976) Mech Age Dev , vol.5 , Issue.1 , pp. 33-38
    • Lintern-Moore, S.1    Pantelouris, E.M.2
  • 11
    • 0035160814 scopus 로고    scopus 로고
    • Altered functional responses with preserved morphology of go- nadotrophic cells in congenitally athymic mice
    • Goya RG, Cónsole GM, Sosa YE, Gómez-Dumm CLA, Dardenne M. Altered functional responses with preserved morphology of go- nadotrophic cells in congenitally athymic mice. Brain Behav Im- mun 2001; 15: 85-92.
    • (2001) Brain Behav Im- Mun , vol.15 , pp. 85-92
    • Goya, R.G.1    Cónsole, G.M.2    Sosa, Y.E.3    Gómez-Dumm, C.L.A.4    Dardenne, M.5
  • 12
    • 0029079889 scopus 로고
    • Altered thyrotropic and somatotropic responses to environmental challenges in con-genitally athymic mice
    • Goya RG, Sosa YE, Cónsole GM, Dardenne M. Altered thyrotropic and somatotropic responses to environmental challenges in con-genitally athymic mice. Brain Behav Immun 1995; 9: 79-86.
    • (1995) Brain Behav Immun , vol.9 , pp. 79-86
    • Goya, R.G.1    Sosa, Y.E.2    Cónsole, G.M.3    Dardenne, M.4
  • 14
    • 0029015812 scopus 로고
    • Impaired hypo-thalamo-pituitary-adrenal axis function in swiss nude athymic mice
    • Daneva T, Spinedi E, Hadid R, Gaillard RC. Impaired hypo-thalamo-pituitary-adrenal axis function in swiss nude athymic mice. Neuroendocrinology 1995; 62: 79-86.
    • (1995) Neuroendocrinology , vol.62 , pp. 79-86
    • Daneva, T.1    Spinedi, E.2    Hadid, R.3    Gaillard, R.C.4
  • 15
    • 0034453056 scopus 로고    scopus 로고
    • Neuroendocrine control of thymus physiology
    • 2000
    • Savino W, Dardenne M 2000. Neuroendocrine control of thymus physiology. Endocrine Rev 2000; 21: 412-43.
    • (2000) Endocrine Rev , vol.21 , pp. 412-443
    • Savino, W.1    Dardenne, M.2
  • 16
  • 17
    • 0016340661 scopus 로고
    • Studies on thymus products. III. Epithelial origin of the serum thymic factor
    • Dardenne M, Papiernik M, Bach JF, Stutman O. Studies on thymus products. III. Epithelial origin of the serum thymic factor. Immunology 1974; 27: 299-304.
    • (1974) Immunology , vol.27 , pp. 299-304
    • Dardenne, M.1    Papiernik, M.2    Bach, J.F.3    Stutman, O.4
  • 19
    • 0040815826 scopus 로고
    • Contribution of zinc and other metals to the biological activity of serum thymic factor (FTS)
    • Dardenne M, Nabarra B, Lefrancier P. Contribution of zinc and other metals to the biological activity of serum thymic factor (FTS). Proc Natl Acad Sci USA 1982; 79: 5370-3.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 5370-5373
    • Dardenne, M.1    Nabarra, B.2    Lefrancier, P.3
  • 20
    • 0023928863 scopus 로고
    • NMR study of a lymphocyte differentiating thymic factor
    • Cung MT, Marraud M, Lefrancier P. NMR study of a lymphocyte differentiating thymic factor. J Biol Chem 1988; 263: 5574-80.
    • (1988) J Biol Chem , vol.263 , pp. 5574-5580
    • Cung, M.T.1    Marraud, M.2    Lefrancier, P.3
  • 21
    • 0020586663 scopus 로고
    • Thymic hormones containing cells. III. Evidence for a feed-back regulation of the secretion of the serum thymic factor (FTS) by thymic epithelial cells
    • Savino W, Dardenne M, Bach JF. Thymic hormones containing cells. III. Evidence for a feed-back regulation of the secretion of the serum thymic factor (FTS) by thymic epithelial cells. Clin Exp Immunol 1983; 52: 7-12.
    • (1983) Clin Exp Immunol , vol.52 , pp. 7-12
    • Savino, W.1    Dardenne, M.2    Bach, J.F.3
  • 22
    • 0022502758 scopus 로고
    • Feed-back regulation of the secretion of a thymic hormone (thymulin) by human thymic epithelial cells in culture
    • Cohen S, Berrih S, Dardenne M, Bach JF. Feed-back regulation of the secretion of a thymic hormone (thymulin) by human thymic epithelial cells in culture. Thymus 1986; 8: 109-19.
    • (1986) Thymus , vol.8 , pp. 109-119
    • Cohen, S.1    Berrih, S.2    Dardenne, M.3    Bach, J.F.4
  • 25
    • 0023220666 scopus 로고
    • Growth hormone treatment stimulates thymulin production in aged dogs
    • Goff BL, Roth JA, Arp LH, Incefy GS. Growth hormone treatment stimulates thymulin production in aged dogs. Clin Exp Immunol 1987; 68: 580-7.
    • (1987) Clin Exp Immunol , vol.68 , pp. 580-587
    • Goff, B.L.1    Roth, J.A.2    Arp, L.H.3    Incefy, G.S.4
  • 29
    • 0026093771 scopus 로고
    • Identification and functional activity of prolactin receptors in thymic epithelial cells
    • Dardenne M, Kelly PA, Bach JF, Savino W. Identification and functional activity of prolactin receptors in thymic epithelial cells. Proc Natl Acad Sci USA 1991; 88: 9700-4.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9700-9704
    • Dardenne, M.1    Kelly, P.A.2    Bach, J.F.3    Savino, W.4
  • 30
    • 0024341247 scopus 로고
    • Neu-roendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells
    • Dardenne M, Savino W, Gagnerault MC, Itoh T, Bach JF. Neu-roendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. Endocrinology 1989; 125: 3-12.
    • (1989) Endocrinology , vol.125 , pp. 3-12
    • Dardenne, M.1    Savino, W.2    Gagnerault, M.C.3    Itoh, T.4    Bach, J.F.5
  • 31
    • 0021905224 scopus 로고
    • Endocrine control of thymic serum factor production in young-adult and old mice
    • Fabris N, Mocchegiani E. Endocrine control of thymic serum factor production in young-adult and old mice. Cell Immunol 1985; 91: 325-35.
    • (1985) Cell Immunol , vol.91 , pp. 325-335
    • Fabris, N.1    Mocchegiani, E.2
  • 32
    • 0021330611 scopus 로고
    • Thymic hormone containing cells. IV. Fluctuations in the thyroid hormone levels in vivo can modulate the secretion of thymulin by the epithelial cells of young mouse thymus
    • Savino W, Wolf B, Aratan-Spire S, Dardenne M. Thymic hormone containing cells. IV. Fluctuations in the thyroid hormone levels in vivo can modulate the secretion of thymulin by the epithelial cells of young mouse thymus. Clin Exp Immunol 1984; 55: 629-35.
    • (1984) Clin Exp Immunol , vol.55 , pp. 629-635
    • Savino, W.1    Wolf, B.2    Aratan-Spire, S.3    Dardenne, M.4
  • 35
    • 0025305296 scopus 로고
    • Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones
    • Mocchegiani E, Amadio L, Fabris N. Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones. J Endocrinol Invest 1990; 13: 139-47.
    • (1990) J Endocrinol Invest , vol.13 , pp. 139-147
    • Mocchegiani, E.1    Amadio, L.2    Fabris, N.3
  • 36
    • 0022623645 scopus 로고
    • Thymic hormone-containing cells. VII. Adrenals and gonads control the in vivo secretion of thymulin and its plasmatic inhibitor
    • Dardenne M, Savino W, Duval D, Kaiserlian D, Hassid J, Bach JF. Thymic hormone-containing cells. VII. Adrenals and gonads control the in vivo secretion of thymulin and its plasmatic inhibitor. J Immunol 1986; 136: 1303-8.
    • (1986) J Immunol , vol.136 , pp. 1303-1308
    • Dardenne, M.1    Savino, W.2    Duval, D.3    Kaiserlian, D.4    Hassid, J.5    Bach, J.F.6
  • 37
    • 0023711104 scopus 로고
    • Thymic hormone containing cells. IX. Steroids in vitro modulate thymulin secretion by human and murine thymic epithelial cells
    • Savino W, Bartoccioni E, Homo-Delarche F, Gagnerault MC, Itoh T, Dardenne M. Thymic hormone containing cells. IX. Steroids in vitro modulate thymulin secretion by human and murine thymic epithelial cells. J Steroid Biochem 1988; 30: 479-4.
    • (1988) J Steroid Biochem , vol.30 , pp. 474-479
    • Savino, W.1    Bartoccioni, E.2    Homo-Delarche, F.3    Gagnerault, M.C.4    Itoh, T.5    Dardenne, M.6
  • 38
    • 0022545313 scopus 로고
    • Neuroendocrine regulation of thymus hormones: Hypothalamic dependence of "facteur thymique serique" level
    • Folch H, Eller G, Mena M, Esquivel P. Neuroendocrine regulation of thymus hormones: hypothalamic dependence of "facteur thymique serique" level. Cell Immunol 1986; 102: 211-6.
    • (1986) Cell Immunol , vol.102 , pp. 211-216
    • Folch, H.1    Eller, G.2    Mena, M.3    Esquivel, P.4
  • 39
    • 0028886613 scopus 로고
    • Reduced ability of hypothalamic and pituitary extracts from old mice to stimulate thymulin secretion in vitro
    • Goya RG, Gagnerault MC, Sosa YE, Dardenne M. Reduced ability of hypothalamic and pituitary extracts from old mice to stimulate thymulin secretion in vitro. Mech Age Dev 1995; 83: 143-54.
    • (1995) Mech Age Dev , vol.83 , pp. 143-154
    • Goya, R.G.1    Gagnerault, M.C.2    Sosa, Y.E.3    Dardenne, M.4
  • 40
    • 0024155430 scopus 로고
    • The release of LH from pituitaries perifused with thymic extracts
    • Zaidi SA, Kendall MD, Gillham B, Jones MT. The release of LH from pituitaries perifused with thymic extracts. Thymus 1988; 12: 253-64.
    • (1988) Thymus , vol.12 , pp. 253-264
    • Zaidi, S.A.1    Kendall, M.D.2    Gillham, B.3    Jones, M.T.4
  • 41
    • 0031454396 scopus 로고    scopus 로고
    • Thymulin stimulates corticotrophin release and cyclic nucleotide formation in the rat anterior pituitary gland
    • Hadley AJ, Rantle CM, Buckingham JC. Thymulin stimulates corticotrophin release and cyclic nucleotide formation in the rat anterior pituitary gland. Neuroimmunomodulation 1997; 4: 62-9.
    • (1997) Neuroimmunomodulation , vol.4 , pp. 62-69
    • Hadley, A.J.1    Rantle, C.M.2    Buckingham, J.C.3
  • 42
    • 9644269280 scopus 로고    scopus 로고
    • Effects of thymulin and GnRH on the release of gonadotropins by in vitro pituitary cells obtained from rats in each day of estrous cycle
    • Hinojosa L, García L, Domínguez R, et al. Effects of thymulin and GnRH on the release of gonadotropins by in vitro pituitary cells obtained from rats in each day of estrous cycle. Life Sci 2004; 76: 795-804.
    • (2004) Life Sci , vol.76 , pp. 795-804
    • Hinojosa, L.1    García, L.2    Domínguez, R.3
  • 43
    • 0032167984 scopus 로고    scopus 로고
    • Thymulin stimulates prolactin and thyrotropin release in an age-related manner
    • Brown OA, Sosa YE, Bolognani F, Goya RG. Thymulin stimulates prolactin and thyrotropin release in an age-related manner. Mech Age Dev 1998; 104: 249-62.
    • (1998) Mech Age Dev , vol.104 , pp. 249-262
    • Brown, O.A.1    Sosa, Y.E.2    Bolognani, F.3    Goya, R.G.4
  • 44
    • 0032972658 scopus 로고    scopus 로고
    • Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent
    • Brown OA, Sosa YE, Dardenne M, Pléau J, Goya RG. Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent. Neuroendocrinology 1999; 69: 20-7
    • (1999) Neuroendocrinology , vol.69 , pp. 20-27
    • Brown, O.A.1    Sosa, Y.E.2    Dardenne, M.3    Pléau, J.4    Goya, R.G.5
  • 46
    • 0032693014 scopus 로고    scopus 로고
    • Effects of thymulin on spontaneous puberty and gonadotrophin-induced ovulation in prepubertal normal and hypothymic mice
    • Hinojosa L, Chavira R, Dominguez R, Rosas P. Effects of thymulin on spontaneous puberty and gonadotrophin-induced ovulation in prepubertal normal and hypothymic mice. J Endocrinol 1999; 163: 255-60.
    • (1999) J Endocrinol , vol.163 , pp. 255-260
    • Hinojosa, L.1    Chavira, R.2    Dominguez, R.3    Rosas, P.4
  • 47
    • 0033843242 scopus 로고    scopus 로고
    • Effects of infantile thymectomy on ovarian functions and gonadotrophin-induced ovulation in prepubertal mice: Role of thymulin
    • García L, Hinojosa L, Domínguez R, Chavira R, Rosas P. Effects of infantile thymectomy on ovarian functions and gonadotrophin-induced ovulation in prepubertal mice: role of thymulin. J Endocri-nol 2000; 166: 381-7.
    • (2000) J Endocri-nol , vol.166 , pp. 381-387
    • García, L.1    Hinojosa, L.2    Domínguez, R.3    Chavira, R.4    Rosas, P.5
  • 48
    • 24944514526 scopus 로고    scopus 로고
    • Effects of injecting thymulin into the anterior or medial hypothalamus or the pituitary on induced ovulation in prepubertal mice
    • García L, Hinojosa L, Domínguez R, Chavira R, Rosas P. Effects of injecting thymulin into the anterior or medial hypothalamus or the pituitary on induced ovulation in prepubertal mice. Neuroim-munomodulation 2005; 12: 314-20.
    • (2005) Neuroim-munomodulation , vol.12 , pp. 314-320
    • García, L.1    Hinojosa, L.2    Domínguez, R.3    Chavira, R.4    Rosas, P.5
  • 49
    • 0031815744 scopus 로고    scopus 로고
    • In vitro and in vivo effects of thymulin on rat testicular steroid synthesis
    • Wise T. In vitro and in vivo effects of thymulin on rat testicular steroid synthesis. J Steroid Biochem Mol Biol 1998; 66: 129-35.
    • (1998) J Steroid Biochem Mol Biol , vol.66 , pp. 129-135
    • Wise, T.1
  • 50
    • 33845905185 scopus 로고    scopus 로고
    • Morphometric assessment of the impact of serum thymulin immunoneutralization on pituitary cell populations in peripubertal mice
    • Camihort G, Luna G, Vesenbeckh S, et al. Morphometric assessment of the impact of serum thymulin immunoneutralization on pituitary cell populations in peripubertal mice. Cells Tissues Organs 2006; 184: 23-30.
    • (2006) Cells Tissues Organs , vol.184 , pp. 23-30
    • Camihort, G.1    Luna, G.2    Vesenbeckh, S.3
  • 51
    • 79959376731 scopus 로고    scopus 로고
    • Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice
    • Martines EV, Reggiani PC, Schwerdt JI, Goya RG, Cónsole GM. Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice. Cells Tissues Organs 2011; 194: 67-75.
    • (2011) Cells Tissues Organs , vol.194 , pp. 67-75
    • Martines, E.V.1    Reggiani, P.C.2    Schwerdt, J.I.3    Goya, R.G.4    Cónsole, G.M.5
  • 52
    • 34547207209 scopus 로고    scopus 로고
    • Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice
    • E182-7
    • Goya RG, Reggiani PC, Vesenbeckh SM, et al. Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. Am J Physiol Endocrinol Metab 2007; 293: E182-7.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Goya, R.G.1    Reggiani, P.C.2    Vesenbeckh, S.M.3
  • 56
    • 34447623547 scopus 로고    scopus 로고
    • Role of thymulin or its analogue as a new analgesic molecule
    • Dardenne M, Saade N, Safieh-Garabedian B. Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci 2006; 1088: 153-63.
    • (2006) Ann N Y Acad Sci , vol.1088 , pp. 153-163
    • Dardenne, M.1    Saade, N.2    Safieh-Garabedian, B.3
  • 58
    • 0142247469 scopus 로고    scopus 로고
    • Thymulin reverses inflammatory hyperalgesia and modulates the increased concentrationn of proinflammatory cytokines induced by ICV en-dotoxin injection
    • Safieh-Garabedian B, Ochoa-Chaar CI, Poole S, et al. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentrationn of proinflammatory cytokines induced by ICV en-dotoxin injection. Neuroscience 2003; 121: 865-73.
    • (2003) Neuroscience , vol.121 , pp. 865-873
    • Safieh-Garabedian, B.1    Ochoa-Chaar, C.I.2    Poole, S.3
  • 59
    • 0036022638 scopus 로고    scopus 로고
    • Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat
    • Safieh-Garabedian B., Dardenne M, Pleau JM, Saadé NE. Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. Br J Pharmacol 2002; 136: 947-55.
    • (2002) Br J Pharmacol , vol.136 , pp. 947-955
    • Safieh-Garabedian, B.1    Dardenne, M.2    Pleau, J.M.3    Saadé, N.E.4
  • 60
    • 78650834290 scopus 로고    scopus 로고
    • Thy-mulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection
    • Safieh-Garabedian B, Jabbur SJ, Dardenne M, Saadé NE. Thy-mulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection. Neuropharmacology 2011; 60: 496-504.
    • (2011) Neuropharmacology , vol.60 , pp. 496-504
    • Safieh-Garabedian, B.1    Jabbur, S.J.2    Dardenne, M.3    Saadé, N.E.4
  • 63
    • 84867520059 scopus 로고    scopus 로고
    • Targerting neuroin-flammation for therapeutic intervention in neurodegenerative pathologies: A role for the peptide analogue of thymulin (PAT)
    • Safieh-Garabedian B, Mayasi Y, Saadé NE. Targerting neuroin-flammation for therapeutic intervention in neurodegenerative pathologies: a role for the peptide analogue of thymulin (PAT). Expert Opin Ther Targets 2012; 16(11): 1065-73.
    • (2012) Expert Opin Ther Targets , vol.16 , Issue.11 , pp. 1065-1073
    • Safieh-Garabedian, B.1    Mayasi, Y.2    Saadé, N.E.3
  • 64
    • 0028244831 scopus 로고
    • Prevention of diabetes by thymic hormone in alloxan-treated rats
    • Yamanouchi T, Moromizato H, Kojima S, et al. Prevention of diabetes by thymic hormone in alloxan-treated rats. Eur J Pharmacol 1994; 257: 39-46.
    • (1994) Eur J Pharmacol , vol.257 , pp. 39-46
    • Yamanouchi, T.1    Moromizato, H.2    Kojima, S.3
  • 65
    • 0025662985 scopus 로고
    • Anti-thyroglobulin antibodies induced with recombinant reovirus infection in BALB/c mice
    • Onodera T, Awaya A. Anti-thyroglobulin antibodies induced with recombinant reovirus infection in BALB/c mice. Immunology 1990; 71: 581-5.
    • (1990) Immunology , vol.71 , pp. 581-585
    • Onodera, T.1    Awaya, A.2
  • 66
    • 0029690520 scopus 로고    scopus 로고
    • In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice
    • Mizutani M, El-Fotoh M, Mori M, et al. In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice. Arch Virol 1996; 141: 73-83.
    • (1996) Arch Virol , vol.141 , pp. 73-83
    • Mizutani, M.1    El-Fotoh, M.2    Mori, M.3
  • 67
    • 27744502489 scopus 로고    scopus 로고
    • Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats
    • Kohda Y, Matsunaga Y, Yonogi K, Kawai Y, Awaya A, Gemba M. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull 2005; 28: 2087-91.
    • (2005) Biol Pharm Bull , vol.28 , pp. 2087-2091
    • Kohda, Y.1    Matsunaga, Y.2    Yonogi, K.3    Kawai, Y.4    Awaya, A.5    Gemba, M.6
  • 68
    • 25644451873 scopus 로고    scopus 로고
    • Serum thymic factor, FTS, attenuates cisplating nephrotoxicity by suppressing cisplatin-induced ERK activation
    • Kohda Y, Kawai Y, Iwamoto N, et al. Serum thymic factor, FTS, attenuates cisplating nephrotoxicity by suppressing cisplatin-induced ERK activation. Biochem Pharmacol 2005; 70: 408-16.
    • (2005) Biochem Pharmacol , vol.70 , pp. 408-416
    • Kohda, Y.1    Kawai, Y.2    Iwamoto, N.3
  • 69
    • 34247853323 scopus 로고    scopus 로고
    • In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice
    • Sun X, Yamada H, Yoshihara K, Awaya A, Yoshikai Y. In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice. Int Immunopharmacol 2007; 7: 928-36.
    • (2007) Int Immunopharmacol , vol.7 , pp. 928-936
    • Sun, X.1    Yamada, H.2    Yoshihara, K.3    Awaya, A.4    Yoshikai, Y.5
  • 70
    • 50449087582 scopus 로고    scopus 로고
    • Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway
    • Henriques-Coelho T, Oliveira SM, Moura RS, et al. Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway. Endocrinology 2008; 149: 4367-73.
    • (2008) Endocrinology , vol.149 , pp. 4367-4373
    • Henriques-Coelho, T.1    Oliveira, S.M.2    Moura, R.S.3
  • 72
    • 57349127309 scopus 로고    scopus 로고
    • Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice
    • Lunin SM, Khrenov MO, Novoselova TV, Parfenyuk SB, No-voselova EG. Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice. Immunol Invest 2008; 37: 858-70.
    • (2008) Immunol Invest , vol.37 , pp. 858-870
    • Lunin, S.M.1    Khrenov, M.O.2    Novoselova, T.V.3    Parfenyuk, S.B.4    No-Voselova, E.G.5
  • 73
    • 84873196161 scopus 로고    scopus 로고
    • Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis
    • Lunin SM, Glushkova OV, Khrenov MO, et al. Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis. Immunobiology 2012; available from http://dx.dsi.org/10.1016/j.imbio.2012.05.023.
    • (2012) Immunobiology
    • Lunin, S.M.1    Glushkova, O.V.2    Khrenov, M.O.3
  • 74
    • 74949125361 scopus 로고    scopus 로고
    • Involvement of NF-kB transcription factor in the antiinflammatory activity of thymic pep-tides
    • Novoselova EG, Lunin SM, Khrenov MO. Involvement of NF-kB transcription factor in the antiinflammatory activity of thymic pep-tides. Dokl Biol Sci 2009; 428: 484-6.
    • (2009) Dokl Biol Sci , vol.428 , pp. 484-486
    • Novoselova, E.G.1    Lunin, S.M.2    Khrenov, M.O.3
  • 75
    • 0036056406 scopus 로고    scopus 로고
    • Thymus and aging: Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models
    • Goya RG, Cónsole GM, Hereñú CB, Brown OA, Rimoldi OJ. Thymus and aging: potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models. Gerontology 2002; 48: 325-8.
    • (2002) Gerontology , vol.48 , pp. 325-328
    • Goya, R.G.1    Cónsole, G.M.2    Hereñú, C.B.3    Brown, O.A.4    Rimoldi, O.J.5
  • 76
    • 0023900017 scopus 로고
    • Production of biologically active thymulin in Escherichia coli through expression of a chemically synthesized gene
    • Calenda A, Cordonnier A, Lederer F, Le DKH, Pleau JM. Production of biologically active thymulin in Escherichia coli through expression of a chemically synthesized gene. Biotechnol Lett 1988; 10: 155-60.
    • (1988) Biotechnol Lett , vol.10 , pp. 155-160
    • Calenda, A.1    Cordonnier, A.2    Lederer, F.3    Le, D.K.H.4    Pleau, J.M.5
  • 77
    • 33746871159 scopus 로고    scopus 로고
    • Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats
    • Reggiani PC, Hereñú CB, Rimoldi OJ, et al. Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats. Gene Ther 2006; 13: 1214-21.
    • (2006) Gene Ther , vol.13 , pp. 1214-1221
    • Reggiani, P.C.1    Hereñú, C.B.2    Rimoldi, O.J.3
  • 78
    • 33646578169 scopus 로고    scopus 로고
    • Peripheral and mesen-cephalic transfer of a synthetic gene for the thymic peptide thy-mulin
    • Morel GR, Brown OA, Reggiani PC, et al. Peripheral and mesen-cephalic transfer of a synthetic gene for the thymic peptide thy-mulin. Brain Res Bull 2006; 69: 647-51.
    • (2006) Brain Res Bull , vol.69 , pp. 647-651
    • Morel, G.R.1    Brown, O.A.2    Reggiani, P.C.3
  • 79
    • 84864386273 scopus 로고    scopus 로고
    • Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuates reproductive derangements in nude female mice
    • Reggiani PC, Barbeito CG, Zuccolilli GO, et al. Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuates reproductive derangements in nude female mice. Endocrinology 2012; 153: 3922-8.
    • (2012) Endocrinology , vol.153 , pp. 3922-3928
    • Reggiani, P.C.1    Barbeito, C.G.2    Zuccolilli, G.O.3
  • 80
    • 67650264531 scopus 로고    scopus 로고
    • Morphological restoration of gonadotrope population by thymulin gene therapy in nude mice
    • Reggiani PC, Martines E, Ferese C, Goya R, Console GM. Morphological restoration of gonadotrope population by thymulin gene therapy in nude mice. Histol Histopathol 2009; 24: 729-35.
    • (2009) Histol Histopathol , vol.24 , pp. 729-735
    • Reggiani, P.C.1    Martines, E.2    Ferese, C.3    Goya, R.4    Console, G.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.